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学科主题临床医学
Epimedium Extract Promotes Peripheral Nerve Regeneration in Rats
Kou, Yuhui1,2; Wang, Zhiyong3; Wu, Zhihong1,2; Zhang, Peixun3; Zhang, Yu1,2; Yin, Xiaofeng3; Wong, Xisheng1,2; Qiu, Guixing1,2; Jiang, Baoguo3
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2013
DOI10.1155/2013/954798
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]RECOVERY ; INJURY
英文摘要

Effects of Epimedium extract and its constituent icariin on peripheral nerve repair were investigated in a crush injury rat model. Animals were divided into four groups: sham, control, Epimedium extract, and icariin groups. At postoperative weeks 1, 2, 4, and 8, nerve regeneration and functional recovery were evaluated by sciatic functional index (SFI), nerve electrophysiology, nerve pinch test, and muscle wet weight. Results showed that at 2 and 4 weeks after surgery rats in the Epimedium group displayed a better recovery of nerve function than that in the icariin and control groups, with better recovery in the icariin group than in the control group. The nerve pinch test showed that nerve regeneration was greater in the Epimedium group and the icariin group as compared to the control group. In addition, the muscle wet weight in the Epimedium group was significantly improved when compared with the icariin group, and the improvement in the icariin group was better than that in the control group at 8 weeks after operation. Our findings suggest that Epimedium extract effectively promotes peripheral nerve regeneration and improves the function of damaged nerves.

语种英语
WOS记录号WOS:000325025100001
项目编号31171150 ; 31271284 ; 81171146 ; 30971526 ; 30801169 ; A-2008-10 ; BMU 20110270 ; IRT1201
资助机构National Natural Science Fund ; New Star Program of Beijing Science and Technology ; New Century Excellent Talents Support Project of Educational Ministry ; Innovation Team Program of Educational Ministry
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61410
专题北京大学第二临床医学院
北京大学基础医学院
北京大学第二临床医学院_创伤骨科
北京大学第二临床医学院_党委院长办公室
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped, Beijing 100730, Peoples R China
2.Peking Union Med Coll, Beijing 100730, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Trauma Orthoped, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Kou, Yuhui,Wang, Zhiyong,Wu, Zhihong,et al. Epimedium Extract Promotes Peripheral Nerve Regeneration in Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA Kou, Yuhui.,Wang, Zhiyong.,Wu, Zhihong.,Zhang, Peixun.,Zhang, Yu.,...&Jiang, Baoguo.(2013).Epimedium Extract Promotes Peripheral Nerve Regeneration in Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Kou, Yuhui,et al."Epimedium Extract Promotes Peripheral Nerve Regeneration in Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).
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