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学科主题: 临床医学
题名:
Epimedium Extract Promotes Peripheral Nerve Regeneration in Rats
作者: Kou, Yuhui1,2; Wang, Zhiyong3; Wu, Zhihong1,2; Zhang, Peixun3; Zhang, Yu1,2; Yin, Xiaofeng3; Wong, Xisheng1,2; Qiu, Guixing1,2; Jiang, Baoguo3
刊名: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
发表日期: 2013
DOI: 10.1155/2013/954798
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: RECOVERY ; INJURY
英文摘要:

Effects of Epimedium extract and its constituent icariin on peripheral nerve repair were investigated in a crush injury rat model. Animals were divided into four groups: sham, control, Epimedium extract, and icariin groups. At postoperative weeks 1, 2, 4, and 8, nerve regeneration and functional recovery were evaluated by sciatic functional index (SFI), nerve electrophysiology, nerve pinch test, and muscle wet weight. Results showed that at 2 and 4 weeks after surgery rats in the Epimedium group displayed a better recovery of nerve function than that in the icariin and control groups, with better recovery in the icariin group than in the control group. The nerve pinch test showed that nerve regeneration was greater in the Epimedium group and the icariin group as compared to the control group. In addition, the muscle wet weight in the Epimedium group was significantly improved when compared with the icariin group, and the improvement in the icariin group was better than that in the control group at 8 weeks after operation. Our findings suggest that Epimedium extract effectively promotes peripheral nerve regeneration and improves the function of damaged nerves.

语种: 英语
所属项目编号: 31171150 ; 31271284 ; 81171146 ; 30971526 ; 30801169 ; A-2008-10 ; BMU 20110270 ; IRT1201
项目资助者: National Natural Science Fund ; New Star Program of Beijing Science and Technology ; New Century Excellent Talents Support Project of Educational Ministry ; Innovation Team Program of Educational Ministry
WOS记录号: WOS:000325025100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61410
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Orthoped, Beijing 100730, Peoples R China
2.Peking Union Med Coll, Beijing 100730, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Trauma Orthoped, Beijing 100044, Peoples R China

Recommended Citation:
Kou, Yuhui,Wang, Zhiyong,Wu, Zhihong,et al. Epimedium Extract Promotes Peripheral Nerve Regeneration in Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
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