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学科主题: 精神卫生
题名:
The Effects of Antidepressant Treatment on Resting-State Functional Brain Networks in Patients With Major Depressive Disorder
作者: Wang, Li1,2,3; Xia, Mingrui4,5,6; Li, Ke7; Zeng, Yawei7; Su, Yunai1,2,3; Dai, Wenji1,2,3; Zhang, Qinge8; Jin, Zhen7; Mitchell, Philip B.9,10; Yu, Xin1,2,3; He, Yong4,5,6; Si, Tianmei1,2,3
关键词: depression ; antidepressant ; resting-state fMRI ; graph theory ; connectomics
刊名: HUMAN BRAIN MAPPING
发表日期: 2015-02-01
DOI: 10.1002/hbm.22663
卷: 36, 期:2, 页:768-778
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: MOOD-REGULATING CIRCUIT ; MAGNETIC-RESONANCE ; CONNECTIVITY MRI ; GLOBAL SIGNAL ; DEFAULT MODE ; DSM-IV ; FMRI ; FLUCTUATIONS ; CORTEX ; NAIVE
英文摘要:

Although most knowledge regarding antidepressant effects is at the receptor level, the neurophysiological correlates of these neurochemical changes remain poorly understood. Such an understanding could benefit from elucidation of antidepressant effects at the level of neural circuits, which would be crucial in identifying biomarkers for monitoring treatment efficacy of antidepressants. In this study, we recruited 20 first-episode drug-naive major depressive disorder (MDD) patients and performed resting-state functional magnetic resonance imaging (MRI) scans before and after 8 weeks of treatment with a selective serotonin reuptake inhibitorescitalopram. Twenty healthy controls (HCs) were also scanned twice with an 8-week interval. Whole-brain connectivity was analyzed using a graph-theory approachfunctional connectivity strength (FCS). The analysis of covariance of FCS was used to determine treatment-related changes. We observed significant group-by-time interaction on FCS in the bilateral dorsomedial prefrontal cortex and bilateral hippocampi. Post hoc analyses revealed that the FCS values in the bilateral dorsomedial prefrontal cortex were significantly higher in the MDD patients compared to HCs at baseline and were significantly reduced after treatment; conversely, the FCS values in the bilateral hippocampi were significantly lower in the patients at baseline and were significantly increased after treatment. Importantly, FCS reduction in the dorsomedial prefrontal cortex was significantly correlated with symptomatic improvement. Together, these findings provided evidence that this commonly used antidepressant can selectively modulate the intrinsic network connectivity associated with the medial prefrontal-limbic system, thus significantly adding to our understanding of antidepressant effects at a circuit level and suggesting potential imaging-based biomarkers for treatment evaluation in MDD. Hum Brain Mapp 36:768-778, 2015. (c) 2014 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 2011ZX09302-004 ; 2014CB846102 ; 2013CB531305 ; 2012CB720704 ; 20130001110106 ; 81030028 ; 31221003 ; 81401479 ; 81225012
项目资助者: "12th Five-year-plan" of National Key Technologies R&amp ; D Program of China ; National Key Basic Research Program of China ; Research Fund for the Doctoral Program of Higher Education of China ; Natural Science Foundation of China ; National Science Fund for Distinguished Young Scholars
WOS记录号: WOS:000348378800028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61418
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Hosp 6, Beijing 100191, Peoples R China
2.Minist Hlth Key Lab Mental Hlth, Beijing, Peoples R China
3.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
4.Peoples Liberat Army, Hosp 306, Dept Radiol, Beijing, Peoples R China
5.Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia
6.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
7.Black Dog Inst, Sydney, NSW, Australia
8.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China
9.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing 100875, Peoples R China
10.Capital Med Univ, Beijing Anding Hosp, Mood Disorders Ctr, Beijing, Peoples R China

Recommended Citation:
Wang, Li,Xia, Mingrui,Li, Ke,et al. The Effects of Antidepressant Treatment on Resting-State Functional Brain Networks in Patients With Major Depressive Disorder[J]. HUMAN BRAIN MAPPING,2015,36(2):768-778.
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