北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心  > 期刊论文
学科主题: 临床医学
题名:
Thyroxine modifies the effects of growth hormone in Ames dwarf mice
作者: Do, Andrew1; Menon, Vinal1,2; Zhi, Xu1,3; Gesing, Adam4; Wiesenborn, Denise S.1,5,6; Spong, Adam7; Sun, Liou7; Bartke, Andrzej7; Masternak, Michal M.1,8
关键词: growth hormone ; insulin ; thyroxine ; Ames dwarf ; longevity
刊名: AGING-US
发表日期: 2015-04-01
卷: 7, 期:4, 页:241-255
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: LONG-LIVED MICE ; CALORIC RESTRICTION ; INSULIN SENSITIVITY ; SKELETAL-MUSCLE ; LIFE-SPAN ; HEALTHY CENTENARIANS ; GH RESISTANCE ; AGING-PROCESS ; IGF-I ; EXPRESSION
英文摘要:

Ames dwarf (df/df) mice lack growth hormone (GH), thyroid stimulating hormone and prolactin. Treatment of juvenile df/df mice with GH alone stimulates somatic growth, reduces insulin sensitivity and shortens lifespan. Early-life treatment with thyroxine (T4) alone produces modest growth stimulation but does not affect longevity. In this study, we examined the effects of treatment of juvenile Ames dwarf mice with a combination of GH + T4 and compared them to the effects of GH alone. Treatment of female and male dwarfs with GH + T4 between the ages of 2 and 8 weeks rescued somatic growth yet did not reduce lifespan to match normal controls, thus contrasting with the previously reported effects of GH alone. While the male dwarf GH + T4 treatment group had no significant effect on lifespan, the female dwarfs undergoing treatment showed a decrease in maximal longevity. Expression of genes related to GH and insulin signaling in the skeletal muscle and white adipose tissue (WAT) of female dwarfs was differentially affected by treatment with GH + T4 vs. GH alone. Differences in the effects of GH + T4 vs. GH alone on insulin target tissues may contribute to the differential effects of these treatments on longevity.

语种: 英语
所属项目编号: R01AG032290 ; P01AG031736
项目资助者: National Institute on Aging of the National Institutes of Health ; Burnett Honors College SMART Grant
WOS记录号: WOS:000354036900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61428
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Med Univ Lodz, Dept Oncol Endocrinol, PL-90752 Lodz, Poland
2.Univ Saarland, Dept Med Biochem & Mol Biol, D-66421 Homburg, Germany
3.So Illinois Univ, Sch Med, Dept Internal Med, Springfield, IL 62794 USA
4.Greater Poland Canc Ctr, Dept Head & Neck Surg, PL-61866 Poznan, Poland
5.Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32827 USA
6.Univ South Carolina Columbia, Sch Med, Dept Cell Biol & Anat, Columbia, SC 29209 USA
7.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China
8.Univ Appl Sci Kaiserslautern, Dept Biotechnol, D-66482 Zweibrucken, Germany

Recommended Citation:
Do, Andrew,Menon, Vinal,Zhi, Xu,et al. Thyroxine modifies the effects of growth hormone in Ames dwarf mice[J]. AGING-US,2015,7(4):241-255.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Do, Andrew]'s Articles
[Menon, Vinal]'s Articles
[Zhi, Xu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Do, Andrew]‘s Articles
[Menon, Vinal]‘s Articles
[Zhi, Xu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace