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Thyroxine modifies the effects of growth hormone in Ames dwarf mice
Do, Andrew1; Menon, Vinal1,2; Zhi, Xu1,3; Gesing, Adam4; Wiesenborn, Denise S.1,5,6; Spong, Adam7; Sun, Liou7; Bartke, Andrzej7; Masternak, Michal M.1,8
关键词growth hormone insulin thyroxine Ames dwarf longevity
刊名AGING-US
2015-04-01
7期:4页:241-255
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]LONG-LIVED MICE ; CALORIC RESTRICTION ; INSULIN SENSITIVITY ; SKELETAL-MUSCLE ; LIFE-SPAN ; HEALTHY CENTENARIANS ; GH RESISTANCE ; AGING-PROCESS ; IGF-I ; EXPRESSION
英文摘要

Ames dwarf (df/df) mice lack growth hormone (GH), thyroid stimulating hormone and prolactin. Treatment of juvenile df/df mice with GH alone stimulates somatic growth, reduces insulin sensitivity and shortens lifespan. Early-life treatment with thyroxine (T4) alone produces modest growth stimulation but does not affect longevity. In this study, we examined the effects of treatment of juvenile Ames dwarf mice with a combination of GH + T4 and compared them to the effects of GH alone. Treatment of female and male dwarfs with GH + T4 between the ages of 2 and 8 weeks rescued somatic growth yet did not reduce lifespan to match normal controls, thus contrasting with the previously reported effects of GH alone. While the male dwarf GH + T4 treatment group had no significant effect on lifespan, the female dwarfs undergoing treatment showed a decrease in maximal longevity. Expression of genes related to GH and insulin signaling in the skeletal muscle and white adipose tissue (WAT) of female dwarfs was differentially affected by treatment with GH + T4 vs. GH alone. Differences in the effects of GH + T4 vs. GH alone on insulin target tissues may contribute to the differential effects of these treatments on longevity.

语种英语
WOS记录号WOS:000354036900005
项目编号R01AG032290 ; P01AG031736
资助机构National Institute on Aging of the National Institutes of Health ; Burnett Honors College SMART Grant
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61428
专题北京大学第三临床医学院_生殖医学中心
作者单位1.Med Univ Lodz, Dept Oncol Endocrinol, PL-90752 Lodz, Poland
2.Univ Saarland, Dept Med Biochem & Mol Biol, D-66421 Homburg, Germany
3.So Illinois Univ, Sch Med, Dept Internal Med, Springfield, IL 62794 USA
4.Greater Poland Canc Ctr, Dept Head & Neck Surg, PL-61866 Poznan, Poland
5.Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32827 USA
6.Univ South Carolina Columbia, Sch Med, Dept Cell Biol & Anat, Columbia, SC 29209 USA
7.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China
8.Univ Appl Sci Kaiserslautern, Dept Biotechnol, D-66482 Zweibrucken, Germany
推荐引用方式
GB/T 7714
Do, Andrew,Menon, Vinal,Zhi, Xu,et al. Thyroxine modifies the effects of growth hormone in Ames dwarf mice[J]. AGING-US,2015,7(4):241-255.
APA Do, Andrew.,Menon, Vinal.,Zhi, Xu.,Gesing, Adam.,Wiesenborn, Denise S..,...&Masternak, Michal M..(2015).Thyroxine modifies the effects of growth hormone in Ames dwarf mice.AGING-US,7(4),241-255.
MLA Do, Andrew,et al."Thyroxine modifies the effects of growth hormone in Ames dwarf mice".AGING-US 7.4(2015):241-255.
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