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学科主题: 临床医学
题名:
Bevacizumab Treatment for Acute Branch Retinal Vein Occlusion Accompanied by Subretinal Hemorrhage
作者: Zhao, Lin; Li, Bingzhen; Feng, Kang; Han, Liang; Ma, Zhizhong; Liu, Yuling
关键词: Bevacizumab ; branch retinal vein occlusion ; macular edema ; optical coherence tomography ; subretinal hemorrhage
刊名: CURRENT EYE RESEARCH
发表日期: 2015-07-01
DOI: 10.3109/02713683.2014.952827
卷: 40, 期:7, 页:752-756
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: OPTICAL COHERENCE TOMOGRAPHY ; SEROUS MACULAR DETACHMENT ; INTRAVITREAL BEVACIZUMAB ; EDEMA ; THERAPY
英文摘要:

Purpose: The purpose of this study was to compare the efficacy of intravitreal bevacizumab (IVB) in the treatment of acute (53 months [mo]. duration) macular edema (ME), with or without subretinal hemorrhage (SRH), resulting from branch retinal vein occlusion (BRVO).

Materials and methods: We conducted a retrospective review of 33 consecutive patients (n = 33 eyes) with ME caused by acute BRVO. All patients received an injection of IVB at baseline examination. All patients were followed monthly, with administration of additional IVB injections if there was persistent or recurrent ME. Specific patterns of ME were investigated using spectral-domain optical coherence tomography (SD-OCT).

Results: SD-OCT revealed serous retinal detachments in the fovea of 15 eyes, 10 of which had accompanying foveal SRH. Based on initial detection of foveal SRH, patients were divided into SRH-negative (n = 23 eyes) or SRH-positive (n = 10 eyes) groups. Initial best-corrected visual acuity (BCVA) did not differ between the two groups. In the SRH-negative group, both BCVA and central macular thickness (CMT) improved significantly after IVB injections (mean, 2.3 injections) at the 6-mo. follow-up examination. In the SRH-positive group, there was no significant improvement in BCVA after IVB injections (mean, 2.0 injections), although there was a significant decrease in CMT. The final BCVA of the SRH-positive group was significantly poorer than that of the SRH-negative group (p = 0.001).

Conclusion: The presence of foveal SRH may be a negative predictor of IVB treatment outcomes for BRVO patients with ME.

语种: 英语
WOS记录号: WOS:000359858000012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61434
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: Peking Univ, Hosp 3, Ctr Eye, Dept Ophthalmol,Key Lab Vis Loss & Restorat,Minis, Beijing 100191, Peoples R China

Recommended Citation:
Zhao, Lin,Li, Bingzhen,Feng, Kang,et al. Bevacizumab Treatment for Acute Branch Retinal Vein Occlusion Accompanied by Subretinal Hemorrhage[J]. CURRENT EYE RESEARCH,2015,40(7):752-756.
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