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学科主题: 临床医学
题名:
Salivary duct carcinoma of the parotid gland: A case report and review of the literature
作者: Xie, Shule1,2; Yang, Hongyu1; Bredell, Marius3; Shen, Shiyue1; Yang, Huijun1; Jin, Long1; Zhang, Shanshan1,2
关键词: salivary duct carcinoma ; salivary gland ; clinic ; immunohistology
刊名: ONCOLOGY LETTERS
发表日期: 2015
DOI: 10.3892/ol.2014.2655
卷: 9, 期:1, 页:371-374
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: EXPRESSION ; TUMORS
英文摘要:

Salivary duct carcinoma (SDC) is a rare and aggressive parotid malignancy that most commonly affects males in the fifth and sixth decades of life. Histopathology specimens obtained from SDC patients demonstrate a resemblance to ductal carcinoma of the breast. Therefore, to distinguish SDC from breast ductal carcinoma, several immunohistochemical markers exist that may enable surgeons to make an accurate diagnosis. In this study, the case of a 54-year-old male with salivary duct carcinoma of the right parotid gland is presented. The results of the present case study revealed that the SDC sample was positive for the expression of human epidermal growth factor 2 (Her-2), cytokeratin (CK) 8/CK 18, p63, high molecular weight CK and calponin, and negative for expression of the estrogen receptor and progesterone receptor. Based on the result, an ipsilateral selective neck dissection followed by adjuvant post-operative radiation therapy was suitable at the primary treatment stage. At one year of follow-up, the patient was alive and free of recurrence. In advanced cases of SDC, treatment with anti-HER-2 monoclonal antibodies, such as trastuzumab, is recommended.

语种: 英语
所属项目编号: S2012010010382 ; JCY20130402114702120
项目资助者: Department of Cranio-maxillofacial and Oral Surgery, University Hospital Zurich (Zurich, Switzerland) ; Guangdong Province Nature Science Foundation ; Shenzhen Science and Research Innovation Foundation
WOS记录号: WOS:000346638300070
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61435
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Dept Oral & Maxillofacial Surg, Shenzhen 518001, Guangdong, Peoples R China
2.Shantou Univ, Coll Med, Shantou 515041, Guangdong, Peoples R China
3.Univ Zurich Hosp, Dept Craniomaxillofacial & Oral Surg, CH-8091 Zurich, Switzerland

Recommended Citation:
Xie, Shule,Yang, Hongyu,Bredell, Marius,et al. Salivary duct carcinoma of the parotid gland: A case report and review of the literature[J]. ONCOLOGY LETTERS,2015,9(1):371-374.
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