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IR@PKUHSC  > 北京大学第三临床医学院  > 皮肤科  > 期刊论文
学科主题: 临床医学
题名:
Overexpression of skin protein kinase C-alpha in anagen hair follicles during induced growth of mouse hair
作者: Li, LF; Guo, J; Gao, ZF
刊名: CLINICAL AND EXPERIMENTAL DERMATOLOGY
发表日期: 2003-07-01
卷: 28, 期:4, 页:429-433
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology
研究领域[WOS]: Dermatology
关键词[WOS]: TUMOR PROMOTION ; DOWN-REGULATION ; EXPRESSION ; ISOENZYMES ; INDUCTION ; EPIDERMIS ; MICE
英文摘要:

A role for protein kinase C (PKC)-alpha has been implicated in the growth of mouse hair. Topical application of PKC activators, hair plucking, allergic contact dermatitis and skin irritation can all enhance growth of mouse hair, and a significant increase in PKC-alpha level in whole mouse skin in mature anagen has been demonstrated in these processes. Overexpression of PKC-alpha in anagen hair follicles has also been reported in natural growth of mouse hair. It is known that overexpression of PKC-alpha is associated with the acceleration of cell growth. Therefore, we postulated that overexpression of PKC-alpha in mature anagen may relate to enhancement of hair growth. The distribution of PKC-alpha in hair follicles during induced growth of mouse hair has not previously been studied. In this study, hair growth in C57BL/6 mice was induced by plucking the telogen hairs on one side of the back. The undepilated contralateral side served as a control. Expression of PKC-alpha in hair follicles during the hair growth cycle induced was evaluated by immunohistochemistry using cryosections and a specific polyclonal anti-PKC-alpha immunoglobulin G (IgG) antibody. No PKC-alpha was detected in telogen hair follicles or in the hair follicles at 1 day post-depilation, when the induced hair cycle was in early anagen. At 4 days after plucking, when the induced hair cycle was in mid-anagen, intense staining for PKC-alpha was found in hair papillae. At 10 and 17 days after depilation, when the induced hair cycle was in mature anagen and early catagen, respectively, all outer root sheath (ORS) cells and outer connective sheaths of hair follicles were stained positive. Because no PKC-alpha was detected in telogen hair follicles in this study, down-regulation of PKC-alpha in early anagen could not be observed. However, consistent with our previous findings, overexpression of PKC-alpha was found in mid-anagen and mature anagen. As overexpression of PKC-alpha has been shown to be associated with acceleration of cell growth, our results support the notion that PKC-alpha may play an important role in growth of hair follicle cells in induced growth of hair. As PKC levels are known to increase in hyperglycaemia, overexpressed PKC-alpha in mature anagen hair follicles may be related to the putative function of the ORS in mobilizing glycogen stores for anagen growth.

语种: 英语
WOS记录号: WOS:000183688900020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61447
Appears in Collections:北京大学第三临床医学院_皮肤科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Dermatol, Beijing 100083, Peoples R China
2.Beijing Univ, Dept Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Li, LF,Guo, J,Gao, ZF. Overexpression of skin protein kinase C-alpha in anagen hair follicles during induced growth of mouse hair[J]. CLINICAL AND EXPERIMENTAL DERMATOLOGY,2003,28(4):429-433.
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