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Detection of anti-C1q antibodies and anti-C1q globular head domain antibodies in sera from Chinese patients with lupus nephritis
Tan, Ying1; Zhou, Wei1,2; Yu, Feng1; Fang, Qiying1; Yang, Hai-zhen3; Zhao, Ming-hui1
关键词Lupus nephritis Anti-C1q antibodies Anti-gC1q antibodies Anti-C1qGR antibodies Anti-C1qCLR antibodies
刊名MOLECULAR IMMUNOLOGY
2009-07-01
DOI10.1016/j.molimm.2009.04.030
46期:11-12页:2178-2182
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Immunology
研究领域[WOS]Biochemistry & Molecular Biology ; Immunology
关键词[WOS]COLLAGEN-LIKE REGION ; HUMAN C1Q ; ERYTHEMATOSUS ; AUTOANTIBODIES
英文摘要

Serum anti-C1q antibodies are associated with disease activity in patients with lupus nephritis. Recent studies showed that anti-C1q antibodies recognize both the collagen region and the globular head regions (gC1q) of individual A (ghA), B (ghB), and C (ghC) chains of C1q molecules. However, the clinical significance of anti-gC1q antibodies was not clear. This study is to investigate the frequency of antibodies against different parts of C1q molecule in sera from patients with lupus nephritis and their clinical significance.

Sera from 83 patients with renal biopsy-proven lupus nephritis were collected at the day of renal biopsy. Sera from 30 patients with non-renal SLE (NR-SLE) and 100 healthy donors were used as controls, Serum anti-C1q antibodies, anti-collagen-like region (C1qCLR) antibodies, anti-globular head region (C1qGR) antibodies and anti-ghA, anti-ghB and anti-ghC antibodies were screened by ELISA using purified human C1q, C1qCLR, C1qGR and recombinant ghA, ghB and ghC as solid phase antigens. The association of these antibodies and clinical and histopathological features was further studied.

The frequencies of positive anti-C1q and anti-C1qCLR antibodies in lupus nephritis group (46/83, 55.4%; 36/83, 43.4%, respectively) were significantly higher than that in patients with NR-SLE (4/30, 13.3%, P<0.001; 5/30. 16.7%, P=0.005, respectively) and healthy donors (5/100, 5.0%, P<0.001; 4/100, 4%, P<0.001, respectively). The levels of both SLE Disease Activity Index (SLEDAI) and renal biopsy Activity Index (AI) of patients were correlated with the levels of anti-C1q antibodies (r=0.520, P<0.001; r=0.321, P=0.003, respectively) and anti-C1qCLR antibodies (r=0.387, P<0.001; r=0.261, P=0.019, respectively). The levels of anti-C1q antibodies were closely correlated with that of anti-C1qCLR antibodies (r=0.588, P<0.001). However, the prevalence of anti-C1qGR, anti-ghA, anti-ghB and anti-ghC antibodies in lupus nephritis group was only 1.2% (1/83), 3.6% (3/83), 2.4% (2/83) and 8.4% (7/83), respectively, which were comparable with that of NR-SLE and normal controls. In conclusion, serum anti-C1q antibodies and anti-C1qCLR antibodies are closely associated with disease activity in patients with lupus nephritis. However, gC1q might not be the dominant epitope of C1q molecule. (C) 2009 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000267685700004
项目编号985-2-033-39
资助机构&prime ; 985&prime ; program of Peking University
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61456
专题北京大学第一临床医学院
北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Dept Med,Renal Div, Minist Hlth China,Key Lab Renal Dis,Inst Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Rheumatol, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Tan, Ying,Zhou, Wei,Yu, Feng,et al. Detection of anti-C1q antibodies and anti-C1q globular head domain antibodies in sera from Chinese patients with lupus nephritis[J]. MOLECULAR IMMUNOLOGY,2009,46(11-12):2178-2182.
APA Tan, Ying,Zhou, Wei,Yu, Feng,Fang, Qiying,Yang, Hai-zhen,&Zhao, Ming-hui.(2009).Detection of anti-C1q antibodies and anti-C1q globular head domain antibodies in sera from Chinese patients with lupus nephritis.MOLECULAR IMMUNOLOGY,46(11-12),2178-2182.
MLA Tan, Ying,et al."Detection of anti-C1q antibodies and anti-C1q globular head domain antibodies in sera from Chinese patients with lupus nephritis".MOLECULAR IMMUNOLOGY 46.11-12(2009):2178-2182.
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