IR@PKUHSC  > 北京大学深圳医院
学科主题临床医学
Expression of PGAM1 in renal clear cell carcinoma and its clinical significance
Li, Chunjing1,2; Shu, Fangpeng1; Lei, Bin1; Lv, Daojun1; Zhang, Shoubo4; Mao, Xiangming1,3
关键词Clear cell renal cell carcinoma PGAM1 clinicalpathological features IHC molecular marker
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2015
8期:8页:9410-9415
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pathology
研究领域[WOS]Oncology ; Pathology
关键词[WOS]PHOSPHOGLYCERATE MUTASE 1 ; IDENTIFICATION ; PROGNOSIS ; PROTEINS
英文摘要

Objective: This study is aimed to evaluate the expression of phosphoglycerate mutase 1 (PGAM1) in normal kidney and clear cell renal cell carcinoma (CCRCC), also to evaluate the correlation between PGAM1 expression and clinicopathological features in CCRCC. Methods: PGAM1 expression was detected in 80 cases of normal kidney and 192 cases of CCRCC by immunohistochemistry (IHC). Meanwhile, PGAM1 expression measured in 8 cases of CCRCC and matched normal kidney tissues by Western blot. Then, the correlation between PGAM1 expression and clinicalpathological features was analyzed in CCRCC. Results: IHC results exhibited that the high-expression rate of PGAM1 in CCRCC tissues was 45.8%, which was significantly higher than those in normal kidney tissues (32.5%, P=0.044). Meanwhile, PGAM1 expression in CCRCC was significantly greater compared with those in normal kidney by Western blot. Moreover, PGAM1 expression was significantly associated with age, tumor size and T stage in CCRCC. Conclusion: PGAM1 is highly expressed in CCRCC and correlated with clinicalpathological features, which may contribute to tumor formation and progression.

语种英语
WOS记录号WOS:000364775400082
项目编号81270743 ; 2013B021800147 ; 20140323125307
资助机构National Natural Science Foundation of China ; Science and Technology Projects of Guangdong Province ; Knowledge Innovation Project of Shenzhen
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61459
专题北京大学深圳医院
作者单位1.Southern Med Univ, Nanfang Hosp, Dept Urol, Guangzhou 515000, Guangdong, Peoples R China
2.Women & Childrens Hosp Foshan, Dept Surg, Foshan, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Shenzhen Pku Hkust Med Ctr, Dept Urol, Shenzhen, Guangdong, Peoples R China
4.Guangzhou Med Univ, Guangdong Armed Police Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Guangzhou, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Li, Chunjing,Shu, Fangpeng,Lei, Bin,et al. Expression of PGAM1 in renal clear cell carcinoma and its clinical significance[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2015,8(8):9410-9415.
APA Li, Chunjing,Shu, Fangpeng,Lei, Bin,Lv, Daojun,Zhang, Shoubo,&Mao, Xiangming.(2015).Expression of PGAM1 in renal clear cell carcinoma and its clinical significance.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,8(8),9410-9415.
MLA Li, Chunjing,et al."Expression of PGAM1 in renal clear cell carcinoma and its clinical significance".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8.8(2015):9410-9415.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Chunjing]的文章
[Shu, Fangpeng]的文章
[Lei, Bin]的文章
百度学术
百度学术中相似的文章
[Li, Chunjing]的文章
[Shu, Fangpeng]的文章
[Lei, Bin]的文章
必应学术
必应学术中相似的文章
[Li, Chunjing]的文章
[Shu, Fangpeng]的文章
[Lei, Bin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。