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学科主题: 临床医学
题名:
Expression of PGAM1 in renal clear cell carcinoma and its clinical significance
作者: Li, Chunjing1,2; Shu, Fangpeng1; Lei, Bin1; Lv, Daojun1; Zhang, Shoubo4; Mao, Xiangming1,3
关键词: Clear cell renal cell carcinoma ; PGAM1 ; clinicalpathological features ; IHC ; molecular marker
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
发表日期: 2015
卷: 8, 期:8, 页:9410-9415
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pathology
研究领域[WOS]: Oncology ; Pathology
关键词[WOS]: PHOSPHOGLYCERATE MUTASE 1 ; IDENTIFICATION ; PROGNOSIS ; PROTEINS
英文摘要:

Objective: This study is aimed to evaluate the expression of phosphoglycerate mutase 1 (PGAM1) in normal kidney and clear cell renal cell carcinoma (CCRCC), also to evaluate the correlation between PGAM1 expression and clinicopathological features in CCRCC. Methods: PGAM1 expression was detected in 80 cases of normal kidney and 192 cases of CCRCC by immunohistochemistry (IHC). Meanwhile, PGAM1 expression measured in 8 cases of CCRCC and matched normal kidney tissues by Western blot. Then, the correlation between PGAM1 expression and clinicalpathological features was analyzed in CCRCC. Results: IHC results exhibited that the high-expression rate of PGAM1 in CCRCC tissues was 45.8%, which was significantly higher than those in normal kidney tissues (32.5%, P=0.044). Meanwhile, PGAM1 expression in CCRCC was significantly greater compared with those in normal kidney by Western blot. Moreover, PGAM1 expression was significantly associated with age, tumor size and T stage in CCRCC. Conclusion: PGAM1 is highly expressed in CCRCC and correlated with clinicalpathological features, which may contribute to tumor formation and progression.

语种: 英语
所属项目编号: 81270743 ; 2013B021800147 ; 20140323125307
项目资助者: National Natural Science Foundation of China ; Science and Technology Projects of Guangdong Province ; Knowledge Innovation Project of Shenzhen
WOS记录号: WOS:000364775400082
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61459
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Southern Med Univ, Nanfang Hosp, Dept Urol, Guangzhou 515000, Guangdong, Peoples R China
2.Women & Childrens Hosp Foshan, Dept Surg, Foshan, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Shenzhen Pku Hkust Med Ctr, Dept Urol, Shenzhen, Guangdong, Peoples R China
4.Guangzhou Med Univ, Guangdong Armed Police Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Li, Chunjing,Shu, Fangpeng,Lei, Bin,et al. Expression of PGAM1 in renal clear cell carcinoma and its clinical significance[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2015,8(8):9410-9415.
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