北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学深圳医院  > 期刊论文
学科主题: 临床医学
题名:
Expression of PGAM1 in renal clear cell carcinoma and its clinical significance
作者: Li, Chunjing1,2; Shu, Fangpeng1; Lei, Bin1; Lv, Daojun1; Zhang, Shoubo4; Mao, Xiangming1,3
关键词: Clear cell renal cell carcinoma ; PGAM1 ; clinicalpathological features ; IHC ; molecular marker
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
发表日期: 2015
卷: 8, 期:8, 页:9410-9415
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pathology
研究领域[WOS]: Oncology ; Pathology
关键词[WOS]: PHOSPHOGLYCERATE MUTASE 1 ; IDENTIFICATION ; PROGNOSIS ; PROTEINS
英文摘要:

Objective: This study is aimed to evaluate the expression of phosphoglycerate mutase 1 (PGAM1) in normal kidney and clear cell renal cell carcinoma (CCRCC), also to evaluate the correlation between PGAM1 expression and clinicopathological features in CCRCC. Methods: PGAM1 expression was detected in 80 cases of normal kidney and 192 cases of CCRCC by immunohistochemistry (IHC). Meanwhile, PGAM1 expression measured in 8 cases of CCRCC and matched normal kidney tissues by Western blot. Then, the correlation between PGAM1 expression and clinicalpathological features was analyzed in CCRCC. Results: IHC results exhibited that the high-expression rate of PGAM1 in CCRCC tissues was 45.8%, which was significantly higher than those in normal kidney tissues (32.5%, P=0.044). Meanwhile, PGAM1 expression in CCRCC was significantly greater compared with those in normal kidney by Western blot. Moreover, PGAM1 expression was significantly associated with age, tumor size and T stage in CCRCC. Conclusion: PGAM1 is highly expressed in CCRCC and correlated with clinicalpathological features, which may contribute to tumor formation and progression.

语种: 英语
所属项目编号: 81270743 ; 2013B021800147 ; 20140323125307
项目资助者: National Natural Science Foundation of China ; Science and Technology Projects of Guangdong Province ; Knowledge Innovation Project of Shenzhen
WOS记录号: WOS:000364775400082
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61459
Appears in Collections:北京大学深圳医院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Southern Med Univ, Nanfang Hosp, Dept Urol, Guangzhou 515000, Guangdong, Peoples R China
2.Women & Childrens Hosp Foshan, Dept Surg, Foshan, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Shenzhen Pku Hkust Med Ctr, Dept Urol, Shenzhen, Guangdong, Peoples R China
4.Guangzhou Med Univ, Guangdong Armed Police Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Li, Chunjing,Shu, Fangpeng,Lei, Bin,et al. Expression of PGAM1 in renal clear cell carcinoma and its clinical significance[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2015,8(8):9410-9415.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, Chunjing]'s Articles
[Shu, Fangpeng]'s Articles
[Lei, Bin]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, Chunjing]‘s Articles
[Shu, Fangpeng]‘s Articles
[Lei, Bin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace