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Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma
Zhai, Qingna1,2; Zhou, Liang3; Zhao, Chunjuan1,2; Wan, Jun4; Yu, Zhendong1; Guo, Xin3; Qin, Jie3; Chen, Jing3; Lu, Ruijing1,2
关键词Renal cell carcinoma MicroRNA miR-508-3p miR-509-3p
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2012-03-23
DOI10.1016/j.bbrc.2012.02.060
419期:4页:621-626
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]CANCER CELLS ; COLORECTAL-CANCER ; TUMOR-SUPPRESSOR ; MICRORNA ; EXPRESSION ; PROLIFERATION ; GROWTH ; METASTASIS ; MARKERS ; KIDNEY
英文摘要

MicroRNAs (miRNAs) have emerged as powerful regulators of multiple processes linked to human cancer, including cell apoptosis, proliferation and migration, suggesting that the regulation of miRNA function could play a critical role in cancer progression. Recent studies have found that human serum/plasma contains stably expressed miRNAs. If they prove indicative of disease states, miRNAs measured from peripheral blood samples may be a source for routine clinical detection of cancer. Our studies showed that both miR-508-3p and miR-509-3p were down-regulated in renal cancer tissues. The level of miR-508-3p but not miR-509-3p in renal cell carcinoma (RCC) patient plasma demonstrated significant differences from that in control plasma. In addition, the overexpression of miR-508-3p and miR-509-3p suppressed the proliferation of RCC cells (786-0), induced cell apoptosis and inhibited cell migration in vitro. Our data demonstrated that miR-508-3p and miR-509-3p played an important role as tumor suppressor genes during tumor formation and that they may serve as novel diagnostic markers for RCC. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000302335800005
项目编号30900817 ; ZYB200907080110A ; 2011B031800381
资助机构National Natural Science Foundation of China ; Shenzhen-Hong Kong Innovation Circle Project ; Science and Technology Planning Project of Shenzhen in China ; Science and Technology Planning Project of Guangdong Province, China
引用统计
被引频次:56[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61464
专题北京大学深圳医院
作者单位1.Shantou Univ, Coll Med, Guangzhou, Guangdong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Guangzhou, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Guangzhou, Guangdong, Peoples R China
4.Hong Kong Univ Sci & Technol, Div Life Sci, Sect Biochem & Cell Biol, Hong Kong, Hong Kong, Peoples R China
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GB/T 7714
Zhai, Qingna,Zhou, Liang,Zhao, Chunjuan,et al. Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2012,419(4):621-626.
APA Zhai, Qingna.,Zhou, Liang.,Zhao, Chunjuan.,Wan, Jun.,Yu, Zhendong.,...&Lu, Ruijing.(2012).Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,419(4),621-626.
MLA Zhai, Qingna,et al."Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 419.4(2012):621-626.
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