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学科主题: 临床医学
题名:
Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma
作者: Zhai, Qingna1,2; Zhou, Liang3; Zhao, Chunjuan1,2; Wan, Jun4; Yu, Zhendong1; Guo, Xin3; Qin, Jie3; Chen, Jing3; Lu, Ruijing1,2
关键词: Renal cell carcinoma ; MicroRNA ; miR-508-3p ; miR-509-3p
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2012-03-23
DOI: 10.1016/j.bbrc.2012.02.060
卷: 419, 期:4, 页:621-626
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: CANCER CELLS ; COLORECTAL-CANCER ; TUMOR-SUPPRESSOR ; MICRORNA ; EXPRESSION ; PROLIFERATION ; GROWTH ; METASTASIS ; MARKERS ; KIDNEY
英文摘要:

MicroRNAs (miRNAs) have emerged as powerful regulators of multiple processes linked to human cancer, including cell apoptosis, proliferation and migration, suggesting that the regulation of miRNA function could play a critical role in cancer progression. Recent studies have found that human serum/plasma contains stably expressed miRNAs. If they prove indicative of disease states, miRNAs measured from peripheral blood samples may be a source for routine clinical detection of cancer. Our studies showed that both miR-508-3p and miR-509-3p were down-regulated in renal cancer tissues. The level of miR-508-3p but not miR-509-3p in renal cell carcinoma (RCC) patient plasma demonstrated significant differences from that in control plasma. In addition, the overexpression of miR-508-3p and miR-509-3p suppressed the proliferation of RCC cells (786-0), induced cell apoptosis and inhibited cell migration in vitro. Our data demonstrated that miR-508-3p and miR-509-3p played an important role as tumor suppressor genes during tumor formation and that they may serve as novel diagnostic markers for RCC. (C) 2012 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30900817 ; ZYB200907080110A ; 2011B031800381
项目资助者: National Natural Science Foundation of China ; Shenzhen-Hong Kong Innovation Circle Project ; Science and Technology Planning Project of Shenzhen in China ; Science and Technology Planning Project of Guangdong Province, China
WOS记录号: WOS:000302335800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61464
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Shantou Univ, Coll Med, Guangzhou, Guangdong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Guangzhou, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Guangzhou, Guangdong, Peoples R China
4.Hong Kong Univ Sci & Technol, Div Life Sci, Sect Biochem & Cell Biol, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Zhai, Qingna,Zhou, Liang,Zhao, Chunjuan,et al. Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2012,419(4):621-626.
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