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学科主题: 临床医学
题名:
Expression of programmed cell death 5 gene involves in regulation of apoptosis in gastric tumor cells
作者: Yang, Y. -H.; Zhao, M.; Li, W. -M.; Chen, Y. -Y.; Kang, B.; Lu, Y. -Y.
关键词: apoptosis ; gastric cancer ; nuclear translocation ; programmed cell death 5
刊名: APOPTOSIS
发表日期: 2006-06-01
DOI: 10.1007/s10495-006-6714-6
卷: 11, 期:6, 页:993-1001
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: CANCER ; TFAR19 ; LIVER ; CARCINOMA ; PROFILES ; PROTEIN
英文摘要:

The protein of programmed cell death 5 (PDCD5) is believed to participate in regulation of apoptosis. Although PDCD5 is reducibly expressed in various human tumors, it is not clear which expression level of PDCD5 is in gastric cancer (GC). In this study, we have systematically employed the approaches of RT-PCR, Real- time PCR, Immunohistochemistry (IHC), Immunofluorescence staining (IFS) and Western blot to determine the PDCD5 expression in GC cells and primary tumors, at mRNA and protein level, respectively. Our data revealed that the positive rate of PDCD5 expression in the gastric tumor tissues was significantly less than that of the normal tissues (14 out of 102 vs 36 out of 51), whereas, the decreased expression of PDCD5 protein was well correlated with the up-regulated expression of Bcl-2 in these tissues, and the up-regulated expression and nuclear translocation of PDCD5 protein were verified in the apoptotic GC cells induced by Diallyl trisulfide (DATS). Furthermore, the survival curve has suggested that the more PDCD5 expressions were found in the patients, the longer the survival periods were. Therefore, our observations lay down a reasonable postulation that PDCD5 may play a key role to regulate the apoptotic processes in the GC cells and gastric tumors.

语种: 英语
WOS记录号: WOS:000238154300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61469
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing Mol Oncol Lab, Beijing 100036, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China
3.Beijing Airport Ind Zone B 6, Chinese Acad Sci, Beijing Genom Inst, Beijing 101300, Peoples R China

Recommended Citation:
Yang, Y. -H.,Zhao, M.,Li, W. -M.,et al. Expression of programmed cell death 5 gene involves in regulation of apoptosis in gastric tumor cells[J]. APOPTOSIS,2006,11(6):993-1001.
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