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学科主题: 基础医学
题名:
Nuclear accumulation of glioma-associated oncogene 2 protein and enhanced expression of forkhead-box transcription factor M1 protein in human hepatocellular carcinoma
作者: Lin, M.1; Guo, L. M.1; Liu, H.2; Du, J.1; Yang, J.1; Zhang, L. J.2; Zhang, B.1
关键词: Hedgehog pathway ; Glioma-associated oncogene 2 ; Forkhead-box transcription factor M1 ; Hepatocellular carcinoma ; Immunohistochemistry
刊名: HISTOLOGY AND HISTOPATHOLOGY
发表日期: 2010-10-01
卷: 25, 期:10, 页:1269-1275
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Pathology
研究领域[WOS]: Cell Biology ; Pathology
关键词[WOS]: HEDGEHOG SIGNALING PATHWAY ; DOWN-REGULATION ; TARGET GENES ; LUNG-CANCER ; CELLS ; ACTIVATION ; GROWTH ; PROLIFERATION ; GLI1 ; HEPATOCARCINOGENESIS
英文摘要:

The hedgehog (Hh) signaling pathway has been reported to be crucial in human carcinogenesis and tumor progression. Glioma-associated oncogenes (Gli), are zinc finger transcription factors which mediate the transcriptional response to Hh signaling. To explore the role of Gli in the development and progression of hepatocellular carcinoma (HCC), we investigated the expression of Gli2 and FoxM1 (forkhead-box transcription factor M1) which is one of the Gli downstream target genes modulating cell cycle progression in 91 specimens of human HCCs with immunohistochemistry. These immunostaining results were compared with various clinicopathologic parameters. Immunoreactivity of Gli2 and FoxM1 was observed respectively in 84.6% (77/91) and 80.2% (73/91) cases of HCC tumor tissues, and this was considerably higher than expression in the peritumoral tissues. Distribution of Gli2 and FoxM1 proteins in tumor cells was nuclear with or without cytoplasmic staining, or cytoplasmic alone. Statistically, increased nuclear immunopositivity of Gli2 protein correlated significantly with poorer tumor differentiation (P<0.05), as well as with portal vein tumor thrombosis (P<0.05). In addition, overexpression of FoxM1 protein was significantly associated with increased tumor grade (P<0.01) and advanced tumor stage (P<0.05). Moreover, there was a significant association between the expressions of Gli2 and FoxM1 proteins in HCC (r=0.464, P=0.000). This is consistent with the concept that in human HCC, the Hh signaling pathway is involved in the differentiation and proliferation of tumor cells, in part through inducing nuclear accumulation of Gli2 protein and subsequent upregulation of FoxM1 protein.

语种: 英语
所属项目编号: 30700349 ; 30440012
项目资助者: National Natural Science Foundation of China (NSFC)
WOS记录号: WOS:000280888600005
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61473
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100091, Peoples R China
2.Capital Med Univ, Beijing Youan Hosp, Dept Pathol, Beijing, Peoples R China

Recommended Citation:
Lin, M.,Guo, L. M.,Liu, H.,et al. Nuclear accumulation of glioma-associated oncogene 2 protein and enhanced expression of forkhead-box transcription factor M1 protein in human hepatocellular carcinoma[J]. HISTOLOGY AND HISTOPATHOLOGY,2010,25(10):1269-1275.
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