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学科主题基础医学
Nuclear accumulation of glioma-associated oncogene 2 protein and enhanced expression of forkhead-box transcription factor M1 protein in human hepatocellular carcinoma
Lin, M.1; Guo, L. M.1; Liu, H.2; Du, J.1; Yang, J.1; Zhang, L. J.2; Zhang, B.1
关键词Hedgehog pathway Glioma-associated oncogene 2 Forkhead-box transcription factor M1 Hepatocellular carcinoma Immunohistochemistry
刊名HISTOLOGY AND HISTOPATHOLOGY
2010-10-01
25期:10页:1269-1275
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]HEDGEHOG SIGNALING PATHWAY ; DOWN-REGULATION ; TARGET GENES ; LUNG-CANCER ; CELLS ; ACTIVATION ; GROWTH ; PROLIFERATION ; GLI1 ; HEPATOCARCINOGENESIS
英文摘要

The hedgehog (Hh) signaling pathway has been reported to be crucial in human carcinogenesis and tumor progression. Glioma-associated oncogenes (Gli), are zinc finger transcription factors which mediate the transcriptional response to Hh signaling. To explore the role of Gli in the development and progression of hepatocellular carcinoma (HCC), we investigated the expression of Gli2 and FoxM1 (forkhead-box transcription factor M1) which is one of the Gli downstream target genes modulating cell cycle progression in 91 specimens of human HCCs with immunohistochemistry. These immunostaining results were compared with various clinicopathologic parameters. Immunoreactivity of Gli2 and FoxM1 was observed respectively in 84.6% (77/91) and 80.2% (73/91) cases of HCC tumor tissues, and this was considerably higher than expression in the peritumoral tissues. Distribution of Gli2 and FoxM1 proteins in tumor cells was nuclear with or without cytoplasmic staining, or cytoplasmic alone. Statistically, increased nuclear immunopositivity of Gli2 protein correlated significantly with poorer tumor differentiation (P<0.05), as well as with portal vein tumor thrombosis (P<0.05). In addition, overexpression of FoxM1 protein was significantly associated with increased tumor grade (P<0.01) and advanced tumor stage (P<0.05). Moreover, there was a significant association between the expressions of Gli2 and FoxM1 proteins in HCC (r=0.464, P=0.000). This is consistent with the concept that in human HCC, the Hh signaling pathway is involved in the differentiation and proliferation of tumor cells, in part through inducing nuclear accumulation of Gli2 protein and subsequent upregulation of FoxM1 protein.

语种英语
WOS记录号WOS:000280888600005
项目编号30700349 ; 30440012
资助机构National Natural Science Foundation of China (NSFC)
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61473
专题北京大学基础医学院_病理学系
北京大学基础医学院
北京大学公共卫生学院_北京大学儿童青少年卫生研究所
作者单位1.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100091, Peoples R China
2.Capital Med Univ, Beijing Youan Hosp, Dept Pathol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Lin, M.,Guo, L. M.,Liu, H.,et al. Nuclear accumulation of glioma-associated oncogene 2 protein and enhanced expression of forkhead-box transcription factor M1 protein in human hepatocellular carcinoma[J]. HISTOLOGY AND HISTOPATHOLOGY,2010,25(10):1269-1275.
APA Lin, M..,Guo, L. M..,Liu, H..,Du, J..,Yang, J..,...&Zhang, B..(2010).Nuclear accumulation of glioma-associated oncogene 2 protein and enhanced expression of forkhead-box transcription factor M1 protein in human hepatocellular carcinoma.HISTOLOGY AND HISTOPATHOLOGY,25(10),1269-1275.
MLA Lin, M.,et al."Nuclear accumulation of glioma-associated oncogene 2 protein and enhanced expression of forkhead-box transcription factor M1 protein in human hepatocellular carcinoma".HISTOLOGY AND HISTOPATHOLOGY 25.10(2010):1269-1275.
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