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学科主题基础医学
EFFECT OF A FERMENTED NUTRACEUTICAL ON THIOREDOXIN LEVEL AND TNF-alpha SIGNALLING IN CIRRHOTIC PATIENTS
Marotta, F.1; Chui, D. H.2; Jain, S.3; Polimeni, A.1; Koike, K.4; Zhou, L.2; Lorenzetti, A.1; Shimizu, H.4; Yang, H.2
关键词reactive oxygen species thioredoxin fermented papaya preparation TNF-alpha liver cirrhosis
刊名JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
2011
25期:1页:37-45
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Immunology ; Medicine, Research & Experimental ; Physiology
研究领域[WOS]Endocrinology & Metabolism ; Immunology ; Research & Experimental Medicine ; Physiology
关键词[WOS]CHRONIC HEPATITIS-C ; OXIDATIVE STRESS ; HEPATOCELLULAR-CARCINOMA ; PAPAYA PREPARATION ; VIRAL-HEPATITIS ; VIRUS-INFECTION ; VITAMIN-E ; LIVER ; DAMAGE ; CANCER
英文摘要

The aim of this study is to gain further insights into the possible nutraceutical effect on redox balance via thioredoxin (Trx) modulation and on the intrinsic susceptibility of monocytes to generate an inflammatory response. The study group consisted of thirty-two patients with compensated Child A-C, HCV-related cirrhosis. The patients were supplemented for 6 months with 6g/day of a certified fermented papaya preparation (FPP). Fifteen unsupplemented, age/gender-matched healthy subjects served as controls. The patients filled in a detailed diet-life style questionnaire, and blood samples were collected to test routine biochemistry, Trx, redox stains (GSH, GSSG, GSH/GSSG ratio, 4-HNE and alpha-tocopherol). Moreover, isolated monocytes were tested for ex-vivo LPS-stimulated TNF alpha production and TNF alpha mRNA. As compared to control, patients with liver cirrhosis showed a significantly higher serum level of Trx. A significant correlation occurred with GSH/GSSG ratio in Child B and C patients. FPP supplementation brought about a significant reduction of Trx with levels comparable to the ones of healthy controls. Ten patients Child C (31.2%) showed borderline low levels of alpha-tocopherol while all cirrhotic patients, as a whole, showed a significantly abnormal redox balance. Supplementation with FPP did not modify alpha-tocopherol depletion but significantly improved redox balance parameters. Patients with liver cirrhosis showed a significantly upregulated TNF-alpha production in a time-dependent manner and this effect was more pronounced in more advanced stages of the disease and showed a significant correlation with alpha-tocopherol level. Supplementation with FPP significantly, although partially, downregulated TNF-alpha production from monocytes. Taken altogether, it would appear that the typical oxidative-inflammatory biochemical milieu of these patients is mirrored by a significant TNF-alpha upregulation at a monocyte level while a targeled nutraceutical might be a potentially amenable intervention to be part of validated scheduled treatments.

语种英语
WOS记录号WOS:000288688000006
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61477
专题北京大学基础医学院_神经生物学系
作者单位1.ReGenera Res Grp Aging Intervent, Milan, Italy
2.Osato Res Inst & Biosci Lab, Gifu, Japan
3.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing, Peoples R China
4.Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA
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GB/T 7714
Marotta, F.,Chui, D. H.,Jain, S.,et al. EFFECT OF A FERMENTED NUTRACEUTICAL ON THIOREDOXIN LEVEL AND TNF-alpha SIGNALLING IN CIRRHOTIC PATIENTS[J]. JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS,2011,25(1):37-45.
APA Marotta, F..,Chui, D. H..,Jain, S..,Polimeni, A..,Koike, K..,...&Yang, H..(2011).EFFECT OF A FERMENTED NUTRACEUTICAL ON THIOREDOXIN LEVEL AND TNF-alpha SIGNALLING IN CIRRHOTIC PATIENTS.JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS,25(1),37-45.
MLA Marotta, F.,et al."EFFECT OF A FERMENTED NUTRACEUTICAL ON THIOREDOXIN LEVEL AND TNF-alpha SIGNALLING IN CIRRHOTIC PATIENTS".JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS 25.1(2011):37-45.
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