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学科主题: 基础医学
题名:
EFFECT OF A FERMENTED NUTRACEUTICAL ON THIOREDOXIN LEVEL AND TNF-alpha SIGNALLING IN CIRRHOTIC PATIENTS
作者: Marotta, F.1; Chui, D. H.2; Jain, S.3; Polimeni, A.1; Koike, K.4; Zhou, L.2; Lorenzetti, A.1; Shimizu, H.4; Yang, H.2
关键词: reactive oxygen species ; thioredoxin ; fermented papaya preparation ; TNF-alpha ; liver cirrhosis
刊名: JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
发表日期: 2011
卷: 25, 期:1, 页:37-45
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Immunology ; Medicine, Research & Experimental ; Physiology
研究领域[WOS]: Endocrinology & Metabolism ; Immunology ; Research & Experimental Medicine ; Physiology
关键词[WOS]: CHRONIC HEPATITIS-C ; OXIDATIVE STRESS ; HEPATOCELLULAR-CARCINOMA ; PAPAYA PREPARATION ; VIRAL-HEPATITIS ; VIRUS-INFECTION ; VITAMIN-E ; LIVER ; DAMAGE ; CANCER
英文摘要:

The aim of this study is to gain further insights into the possible nutraceutical effect on redox balance via thioredoxin (Trx) modulation and on the intrinsic susceptibility of monocytes to generate an inflammatory response. The study group consisted of thirty-two patients with compensated Child A-C, HCV-related cirrhosis. The patients were supplemented for 6 months with 6g/day of a certified fermented papaya preparation (FPP). Fifteen unsupplemented, age/gender-matched healthy subjects served as controls. The patients filled in a detailed diet-life style questionnaire, and blood samples were collected to test routine biochemistry, Trx, redox stains (GSH, GSSG, GSH/GSSG ratio, 4-HNE and alpha-tocopherol). Moreover, isolated monocytes were tested for ex-vivo LPS-stimulated TNF alpha production and TNF alpha mRNA. As compared to control, patients with liver cirrhosis showed a significantly higher serum level of Trx. A significant correlation occurred with GSH/GSSG ratio in Child B and C patients. FPP supplementation brought about a significant reduction of Trx with levels comparable to the ones of healthy controls. Ten patients Child C (31.2%) showed borderline low levels of alpha-tocopherol while all cirrhotic patients, as a whole, showed a significantly abnormal redox balance. Supplementation with FPP did not modify alpha-tocopherol depletion but significantly improved redox balance parameters. Patients with liver cirrhosis showed a significantly upregulated TNF-alpha production in a time-dependent manner and this effect was more pronounced in more advanced stages of the disease and showed a significant correlation with alpha-tocopherol level. Supplementation with FPP significantly, although partially, downregulated TNF-alpha production from monocytes. Taken altogether, it would appear that the typical oxidative-inflammatory biochemical milieu of these patients is mirrored by a significant TNF-alpha upregulation at a monocyte level while a targeled nutraceutical might be a potentially amenable intervention to be part of validated scheduled treatments.

语种: 英语
WOS记录号: WOS:000288688000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61477
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.ReGenera Res Grp Aging Intervent, Milan, Italy
2.Osato Res Inst & Biosci Lab, Gifu, Japan
3.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing, Peoples R China
4.Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA

Recommended Citation:
Marotta, F.,Chui, D. H.,Jain, S.,et al. EFFECT OF A FERMENTED NUTRACEUTICAL ON THIOREDOXIN LEVEL AND TNF-alpha SIGNALLING IN CIRRHOTIC PATIENTS[J]. JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS,2011,25(1):37-45.
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