北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Effect of once-daily indacaterol in a predominantly Chinese population with chronic obstructive pulmonary disease: A 26-week Asia-Pacific study
作者: Yao, Wanzhen1; Wang, Changzheng2; Zhong, Nanshan3; Han, Xiaowen4; Wu, Changgui6; Yan, Xixin5; Chen, Ping7; Yang, Wei8; Henley, Michelle8; Kramer, Benjamin8
关键词: Chinese ; chronic obstructive pulmonary disease ; efficacy ; indacaterol ; safety
刊名: RESPIROLOGY
发表日期: 2014-02-01
DOI: 10.1111/resp.12211
卷: 19, 期:2, 页:231-238
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Respiratory System
研究领域[WOS]: Respiratory System
关键词[WOS]: AIR-FLOW OBSTRUCTION ; LUNG HYPERINFLATION ; DOUBLE-BLIND ; COPD ; EXERCISE ; EFFICACY ; BRONCHODILATORS ; SALMETEROL ; TIOTROPIUM ; TRIAL
英文摘要:

Background and objectiveThis study, in a predominantly Chinese population, investigated the efficacy and safety of a once-daily (o.d.) inhaled ultra-long-acting (2)-agonist indacaterol for the treatment of moderate-to-severe chronic obstructive pulmonary disease (COPD).

MethodsThis is a 26-week, double-blind study on randomized patients who received indacaterol 150g or 300g or placebo o.d. The primary variable was trough forced expiratory volume in 1s (FEV1, average of 23h 10min and 23h 45min post-dose values) at Week 12. Health status (St George′s Respiratory Questionnaire, SGRQ), dyspnoea (transition dyspnoea index, TDI) and safety were evaluated over 26 weeks.

ResultsOf the 563 patients randomized, 561 (89.8% Chinese) received treatment and 482 completed. At Week 12, trough FEV1 improved significantly for indacaterol 150 and 300g versus placebo (1.32, 1.29 vs 1.17; P<0.001 for both comparisons), with differences exceeding the pre-specified minimal clinically important difference of 0.12L. At Week 26, TDI score was superior to placebo for indacaterol 150 and 300g (0.82, 1.15; P<0.01), as was the percentage of patients with a clinically relevant improvement (1 point) (74.1%, 78.6% vs 55.5%; P<0.05). Both doses provided 4-point improvements from baseline in SGRQ score at Week 26 that were numerically greater than placebo (unadjusted means: -9.6, -8.8 vs -7.0), with a similar pattern in percentage of patients with clinically relevant improvements in SGRQ score (65.0%, 61.5% vs 60.6%). Incidences of adverse events were comparable across treatment groups.

ConclusionsIndacaterol delivered effective bronchodilation with significant improvements in breathlessness and health status in this predominantly Chinese population.

We investigated the effect of indacaterol on FEV1, dyspnoea and health-related quality of life in a predominantly Chinese population diagnosed with moderate-to-severe COPD. Indacaterol proved to be a useful treatment option as it showed effective bronchodilation and improvements in breathlessness and health status in this population.

语种: 英语
项目资助者: Novartis Pharma AG, Basel, Switzerland
WOS记录号: WOS:000330798700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61479
Appears in Collections:北京大学第三临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3, Beijing 100083, Peoples R China
2.Guangzhou Inst Resp Dis, Guangzhou, Guangdong, Peoples R China
3.Peoples Hosp Hebei Prov, Shijiazhuang, Peoples R China
4.Hebei Med Univ, Hosp 2, Shijiazhuang, Peoples R China
5.Xijing Hosp, Dept Resp Med, Xian, Peoples R China
6.Novartis Pharmaceut, E Hanover, NJ USA
7.Third Mil Med Univ, Xingiao Hosp, Chongqing, Peoples R China
8.Cent S Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China

Recommended Citation:
Yao, Wanzhen,Wang, Changzheng,Zhong, Nanshan,et al. Effect of once-daily indacaterol in a predominantly Chinese population with chronic obstructive pulmonary disease: A 26-week Asia-Pacific study[J]. RESPIROLOGY,2014,19(2):231-238.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yao, Wanzhen]'s Articles
[Wang, Changzheng]'s Articles
[Zhong, Nanshan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yao, Wanzhen]‘s Articles
[Wang, Changzheng]‘s Articles
[Zhong, Nanshan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace