IR@PKUHSC  > 北京大学第三临床医学院  > 运动医学研究所
学科主题临床医学
Diet and gene expression: Delta-5 and delta-6 desaturases in healthy Chinese and European subjects
Xiang, M.; Rahman, M. A.; Ai, H.; Li, X.; Harbige, L. S.
关键词Chinese and Europeans gene expression long-chain polyunsaturated fatty acids
刊名ANNALS OF NUTRITION AND METABOLISM
2006
DOI10.1159/000095829
50期:6页:492-498
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Nutrition & Dietetics
研究领域[WOS]Endocrinology & Metabolism ; Nutrition & Dietetics
关键词[WOS]POLYUNSATURATED FATTY-ACIDS ; PERIPHERAL-BLOOD LEUKOCYTES ; HUMAN-MILK ; DELTA-6-DESATURASE ACTIVITY ; GROWTH ; METABOLISM ; BRAIN ; RAT ; CHOLESTEROL ; LYMPHOCYTES
英文摘要

Aim: To compare the composition of fatty acids (FAs) in diet, and the expression of delta-6 desaturase (D6D) and delta-5 desaturase (D5D) genes in peripheral blood mononuclear cells (PBMCs) between Chinese and Europeans. Methods: Three-day dietary records from 20 subjects from Beijing, China (n = 10) and Kent, UK (n = 10) were analysed. Expression of PBMC D6D and D5D genes of the subjects was determined using RT-PCR. Results: The dietary intake of Chinese subjects contained less saturated fatty acids (SFAs) and mono-unsaturated fatty acids (MUFAs), but more essential fatty acids (EFAs) than that of Europeans. Levels of expression of PBMC D6D and D5D genes of Chinese subjects were significantly lower than those of Europeans. A significant positive correlation was found between dietary intake of total SFAs and total MUFAs and expression of PBMC D6D and D5D genes, but a significant negative correlation between dietary intake of linoleic acid (LA) and alpha-linolenic acid (LNA) and the expression of PBMC D6D and D5D genes. Conclusion: Intake of high SFAs and MUFAs appears to increase expression of PBMC D6D and D5D genes, whilst high EFAs intake appears to decrease expression of PBMC D6D and D5D genes. A follow-up study of the expression of D6D and D5D genes in Chinese who live in European countries with high SFA and MUFA diets would be of interest. Copyright (c) 2006 S. Karger AG, Basel.

语种英语
WOS记录号WOS:000244207400002
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61483
专题北京大学第三临床医学院_运动医学研究所
作者单位1.Univ Greenwich, Sch Sci, Ctr Biosci Res, Chatham ME4 4TB, Kent, England
2.Univ Kent, Medway Sch Pharm, Canterbury CT2 7NZ, Kent, England
3.Peking Univ, Hosp 3, Inst Sports Med, Div Nutr & Biochem, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Xiang, M.,Rahman, M. A.,Ai, H.,et al. Diet and gene expression: Delta-5 and delta-6 desaturases in healthy Chinese and European subjects[J]. ANNALS OF NUTRITION AND METABOLISM,2006,50(6):492-498.
APA Xiang, M.,Rahman, M. A.,Ai, H.,Li, X.,&Harbige, L. S..(2006).Diet and gene expression: Delta-5 and delta-6 desaturases in healthy Chinese and European subjects.ANNALS OF NUTRITION AND METABOLISM,50(6),492-498.
MLA Xiang, M.,et al."Diet and gene expression: Delta-5 and delta-6 desaturases in healthy Chinese and European subjects".ANNALS OF NUTRITION AND METABOLISM 50.6(2006):492-498.
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