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学科主题: 临床医学
题名:
Diet and gene expression: Delta-5 and delta-6 desaturases in healthy Chinese and European subjects
作者: Xiang, M.; Rahman, M. A.; Ai, H.; Li, X.; Harbige, L. S.
关键词: Chinese and Europeans ; gene expression ; long-chain polyunsaturated fatty acids
刊名: ANNALS OF NUTRITION AND METABOLISM
发表日期: 2006
DOI: 10.1159/000095829
卷: 50, 期:6, 页:492-498
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Nutrition & Dietetics
研究领域[WOS]: Endocrinology & Metabolism ; Nutrition & Dietetics
关键词[WOS]: POLYUNSATURATED FATTY-ACIDS ; PERIPHERAL-BLOOD LEUKOCYTES ; HUMAN-MILK ; DELTA-6-DESATURASE ACTIVITY ; GROWTH ; METABOLISM ; BRAIN ; RAT ; CHOLESTEROL ; LYMPHOCYTES
英文摘要:

Aim: To compare the composition of fatty acids (FAs) in diet, and the expression of delta-6 desaturase (D6D) and delta-5 desaturase (D5D) genes in peripheral blood mononuclear cells (PBMCs) between Chinese and Europeans. Methods: Three-day dietary records from 20 subjects from Beijing, China (n = 10) and Kent, UK (n = 10) were analysed. Expression of PBMC D6D and D5D genes of the subjects was determined using RT-PCR. Results: The dietary intake of Chinese subjects contained less saturated fatty acids (SFAs) and mono-unsaturated fatty acids (MUFAs), but more essential fatty acids (EFAs) than that of Europeans. Levels of expression of PBMC D6D and D5D genes of Chinese subjects were significantly lower than those of Europeans. A significant positive correlation was found between dietary intake of total SFAs and total MUFAs and expression of PBMC D6D and D5D genes, but a significant negative correlation between dietary intake of linoleic acid (LA) and alpha-linolenic acid (LNA) and the expression of PBMC D6D and D5D genes. Conclusion: Intake of high SFAs and MUFAs appears to increase expression of PBMC D6D and D5D genes, whilst high EFAs intake appears to decrease expression of PBMC D6D and D5D genes. A follow-up study of the expression of D6D and D5D genes in Chinese who live in European countries with high SFA and MUFA diets would be of interest. Copyright (c) 2006 S. Karger AG, Basel.

语种: 英语
WOS记录号: WOS:000244207400002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61483
Appears in Collections:北京大学第三临床医学院_运动医学研究所_期刊论文

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作者单位: 1.Univ Greenwich, Sch Sci, Ctr Biosci Res, Chatham ME4 4TB, Kent, England
2.Univ Kent, Medway Sch Pharm, Canterbury CT2 7NZ, Kent, England
3.Peking Univ, Hosp 3, Inst Sports Med, Div Nutr & Biochem, Beijing 100871, Peoples R China

Recommended Citation:
Xiang, M.,Rahman, M. A.,Ai, H.,et al. Diet and gene expression: Delta-5 and delta-6 desaturases in healthy Chinese and European subjects[J]. ANNALS OF NUTRITION AND METABOLISM,2006,50(6):492-498.
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