IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Pathophysiological implication of reversed CT halo sign in invasive pulmonary mucormycosis: a rare case report
Okubo, Yoichiro1; Ishiwatari, Takao1; Izumi, Haruka2; Sato, Fumitomo3; Aki, Kyoko1; Sasai, Daisuke1; Ando, Tsunehiro4; Shinozaki, Minoru1; Natori, Kazuhiko2; Tochigi, Naobumi1; Wakayama, Megumi1; Hata, Yoshinobu3; Nakayama, Haruo5; Nemoto, Tetsuo1; Shibuya, Kazutoshi1,6
关键词Reversed halo sign Mucormycosis Aspergillosis Discrete nodule
刊名DIAGNOSTIC PATHOLOGY
2013-05-17
DOI10.1186/1746-1596-8-82
8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
资助者Janssen Pharmaceutical K. K. ; Dainippon Sumitomo Pharma Co. ; Astellas Pharma Inc. ; Taiho Pharmaceutical Co. ; POLA-Pharma Inc. ; Ministry of Health, Labor and Welfare of Japan ; Strategic Basis on Research Grounds for Non-governmental Schools at Heisei 20th ; Strategic Research Foundation Grant-aided Project for Private schools at Heisei 23rd ; KAKENHI ; Ministry of Education, Culture, Sports, Science, and Technology of Japan ; Toho University ; Yokohama Foundation for Advancement of Medical Science ; Toho University Medical School ; Janssen Pharmaceutical K. K. ; Dainippon Sumitomo Pharma Co. ; Astellas Pharma Inc. ; Taiho Pharmaceutical Co. ; POLA-Pharma Inc. ; Ministry of Health, Labor and Welfare of Japan ; Strategic Basis on Research Grounds for Non-governmental Schools at Heisei 20th ; Strategic Research Foundation Grant-aided Project for Private schools at Heisei 23rd ; KAKENHI ; Ministry of Education, Culture, Sports, Science, and Technology of Japan ; Toho University ; Yokohama Foundation for Advancement of Medical Science ; Toho University Medical School
研究领域[WOS]Pathology
英文摘要

Background: It has been accepted that reversed halo sign (RHS) appeared on a computed tomography (CT) image in immunocompromised patients indicates an invasive fungal infection, but its pathophysiology remains obscure as to what this image implies. Therefore, the present report describes detailed radiological and histopathological findings of a case of invasive pulmonary mucormycosis (IPM) presenting RHS with comparison to those from a lesion of discrete nodule caused by invasive pulmonary aspergillosis (IPA), and discusses the pathophysiological implications of this characteristic image.

Case presentation: RHS had been clinically noted at the time of recovering of bone marrow function of a 64-year-old Japanese man who had chemotherapy for his acute lymphoblastic leukemia. Histological examination of the surgically removed lung revealed a lesion of IPM. This was composed of coagulation necrosis of septa at the center of lesion with preservation of air content which was encompassed outer rim comprising triplet structure; liquefaction, consolidation, and organization from the inner to the outer layer. In addition, Micro-CT examination confirmed reticular structure and monotonous high density at the central coagulation necrosis preserving air content and surrounding consolidation, and organization lesion of the IPM lesion.

Conclusion: Our investigations suggest that RHS might be understood as a kind of immune reconstitution syndrome and be the initial and prior status of air crescent sign.

语种英语
所属项目编号H22-Shinkou-Ippan-8 ; H23-Shinkou-Ippan-018 ; 24790364 ; 23-19 ; 23-21 ; 23-28 ; 24-11 ; 24-16 ; 24-27 ; 24-28
资助者Janssen Pharmaceutical K. K. ; Dainippon Sumitomo Pharma Co. ; Astellas Pharma Inc. ; Taiho Pharmaceutical Co. ; POLA-Pharma Inc. ; Ministry of Health, Labor and Welfare of Japan ; Strategic Basis on Research Grounds for Non-governmental Schools at Heisei 20th ; Strategic Research Foundation Grant-aided Project for Private schools at Heisei 23rd ; KAKENHI ; Ministry of Education, Culture, Sports, Science, and Technology of Japan ; Toho University ; Yokohama Foundation for Advancement of Medical Science ; Toho University Medical School ; Janssen Pharmaceutical K. K. ; Dainippon Sumitomo Pharma Co. ; Astellas Pharma Inc. ; Taiho Pharmaceutical Co. ; POLA-Pharma Inc. ; Ministry of Health, Labor and Welfare of Japan ; Strategic Basis on Research Grounds for Non-governmental Schools at Heisei 20th ; Strategic Research Foundation Grant-aided Project for Private schools at Heisei 23rd ; KAKENHI ; Ministry of Education, Culture, Sports, Science, and Technology of Japan ; Toho University ; Yokohama Foundation for Advancement of Medical Science ; Toho University Medical School
WOS记录号WOS:000319266400001
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61484
Collection北京大学第一临床医学院_皮肤性病科
作者单位1.Toho Univ, Sch Med, Dept Surg Pathol, Ota Ku, Tokyo 1438541, Japan
2.Toho Univ, Med Ctr, Dept Med, Div Hematol & Oncol,Ota Ku, Tokyo 1438541, Japan
3.Toho Univ, Med Ctr, Dept Chest Surg, Ota Ku, Tokyo 1438541, Japan
4.Japanese Red Cross Med Ctr, Dept Resp Med, Shibuya Ku, Tokyo 1508935, Japan
5.Toho Univ, Ohashi Med Ctr, Dept Neurosurg, Meguro Ku, Tokyo 1538515, Japan
6.Peking Univ, Dept Dermatol, Hosp 1, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Okubo, Yoichiro,Ishiwatari, Takao,Izumi, Haruka,et al. Pathophysiological implication of reversed CT halo sign in invasive pulmonary mucormycosis: a rare case report[J]. DIAGNOSTIC PATHOLOGY,2013,8.
APA Okubo, Yoichiro.,Ishiwatari, Takao.,Izumi, Haruka.,Sato, Fumitomo.,Aki, Kyoko.,...&Shibuya, Kazutoshi.(2013).Pathophysiological implication of reversed CT halo sign in invasive pulmonary mucormycosis: a rare case report.DIAGNOSTIC PATHOLOGY,8.
MLA Okubo, Yoichiro,et al."Pathophysiological implication of reversed CT halo sign in invasive pulmonary mucormycosis: a rare case report".DIAGNOSTIC PATHOLOGY 8(2013).
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