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学科主题: 基础医学
题名:
Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system
作者: Li, Gang1,2,3; Wang, Yun1,2,3
关键词: PKD ; neuronal polarity ; pain modulation ; neuroprotection ; learning
刊名: NEUROSCIENCE BULLETIN
发表日期: 2014-06-01
DOI: 10.1007/s12264-013-1403-2
卷: 30, 期:3, 页:497-504
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: PLECKSTRIN HOMOLOGY DOMAIN ; PHORBOL ESTER-BINDING ; CYSTEINE-RICH MOTIFS ; TRANS-GOLGI NETWORK ; COUPLED RECEPTOR ACTIVATION ; C-MU ; IN-VIVO ; CAENORHABDITIS-ELEGANS ; NEURONAL POLARITY ; PKC-MU
英文摘要:

Protein kinase D (PKD) is an evolutionarily-conserved family of protein kinases. It has structural, regulatory, and enzymatic properties quite different from the PKC family. Many stimuli induce PKD signaling, including G-protein-coupled receptor agonists and growth factors. PKD1 is the most studied member of the family. It functions during cell proliferation, differentiation, secretion, cardiac hypertrophy, immune regulation, angiogenesis, and cancer. Previously, we found that PKD1 is also critically involved in pain modulation. Since then, a series of studies performed in our lab and by other groups have shown that PKDs also participate in other processes in the nervous system including neuronal polarity establishment, neuroprotection, and learning. Here, we discuss the connections between PKD structure, enzyme function, and localization, and summarize the recent findings on the roles of PKD-mediated signaling in the nervous system.

语种: 英语
所属项目编号: 81161120497 ; 30925015 ; 30830044 ; 30900582 ; 81221002 ; 2014CB542204
项目资助者: National Natural Science Foundation of China ; National Basic Research Development Program (973 Program) of China
WOS记录号: WOS:000336728700016
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61485
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Natl Hlth & Family Planning Commiss, Dept Neurobiol,Key Lab Neurosci,Minist Educ, Beijing 100871, Peoples R China
3.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China

Recommended Citation:
Li, Gang,Wang, Yun. Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system[J]. NEUROSCIENCE BULLETIN,2014,30(3):497-504.
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