IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system
Li, Gang1,2,3; Wang, Yun1,2,3
关键词PKD neuronal polarity pain modulation neuroprotection learning
刊名NEUROSCIENCE BULLETIN
2014-06-01
DOI10.1007/s12264-013-1403-2
30期:3页:497-504
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]PLECKSTRIN HOMOLOGY DOMAIN ; PHORBOL ESTER-BINDING ; CYSTEINE-RICH MOTIFS ; TRANS-GOLGI NETWORK ; COUPLED RECEPTOR ACTIVATION ; C-MU ; IN-VIVO ; CAENORHABDITIS-ELEGANS ; NEURONAL POLARITY ; PKC-MU
英文摘要

Protein kinase D (PKD) is an evolutionarily-conserved family of protein kinases. It has structural, regulatory, and enzymatic properties quite different from the PKC family. Many stimuli induce PKD signaling, including G-protein-coupled receptor agonists and growth factors. PKD1 is the most studied member of the family. It functions during cell proliferation, differentiation, secretion, cardiac hypertrophy, immune regulation, angiogenesis, and cancer. Previously, we found that PKD1 is also critically involved in pain modulation. Since then, a series of studies performed in our lab and by other groups have shown that PKDs also participate in other processes in the nervous system including neuronal polarity establishment, neuroprotection, and learning. Here, we discuss the connections between PKD structure, enzyme function, and localization, and summarize the recent findings on the roles of PKD-mediated signaling in the nervous system.

语种英语
WOS记录号WOS:000336728700016
项目编号81161120497 ; 30925015 ; 30830044 ; 30900582 ; 81221002 ; 2014CB542204
资助机构National Natural Science Foundation of China ; National Basic Research Development Program (973 Program) of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61485
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Natl Hlth & Family Planning Commiss, Dept Neurobiol,Key Lab Neurosci,Minist Educ, Beijing 100871, Peoples R China
3.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Gang,Wang, Yun. Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system[J]. NEUROSCIENCE BULLETIN,2014,30(3):497-504.
APA Li, Gang,&Wang, Yun.(2014).Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system.NEUROSCIENCE BULLETIN,30(3),497-504.
MLA Li, Gang,et al."Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system".NEUROSCIENCE BULLETIN 30.3(2014):497-504.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Protein kinase D a (310KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Gang]的文章
[Wang, Yun]的文章
百度学术
百度学术中相似的文章
[Li, Gang]的文章
[Wang, Yun]的文章
必应学术
必应学术中相似的文章
[Li, Gang]的文章
[Wang, Yun]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Protein kinase D a new player among the signaling proteins that regulate functions in the nervous system.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。