IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
PON1 polymorphism, diabetes mellitus, obesity, and risk of myocardial infarction: Modifying effect of diabetes mellitus and obesity on the association between PON1 polymorphism and myocardial infarction
Li, JP; Wang, XB; Huo, Y; Niu, TH; Chen, CZ; Zhu, GY; Huang, YM; Chen, DF; Xu, XP
关键词human paraoxonase 1 gene (PON1) polymorphism myocardial infarction diabetes mellitus obesity
刊名GENETICS IN MEDICINE
2005
7期:1页:58-63
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]CORONARY-HEART-DISEASE ; LOW-DENSITY-LIPOPROTEIN ; HUMAN PARAOXONASE GENE ; ARTERY-DISEASE ; GLN-ARG192 POLYMORPHISM ; INSULIN-RESISTANCE ; OXIDATION ; PARTICLES ; HEALTHY ; SUSCEPTIBILITY
英文摘要

Purpose: Previous studies on PON1 gene polymorphism and the risk of coronary atherosclerotic diseases have been inconsistent. This may be in part due to population difference in prevalence of high oxidative stress and its modifying effect on the association. Diabetes and obesity are two major risk factors of myocardial infarction (MI) and associated with high oxidative stress. We investigated the association between PON1 Q192R polymorphism and the risk of myocardial infarction (MI) and in particular, whether the association can be modified by diabetes mellitus (DIVI) and obesity. Methods: We conducted a case-control study, including 154 MI cases and 154 controls enrolled in Beijing, China. Epidemiological and clinical data and PON1 Q192R genotype were obtained from each subject. Results: Without considering the modifying effect of DIVI and obesity, PON1 Q192R polymorphism was not associated with MI. When simultaneously examining the joint association of this polymorphism, DM, and obesity with MI, as compared to subjects with QQ genotypes and without DM and obesity, subjects with QR/RR genotypes and with either DIVI or obesity had significantly higher risk of MI (OR = 3.6, 95% Cl: 1.5-8.7). Conclusion: Our data suggest that PON1 Q192R polymorphism was not independently associated with MI but further increased the risk of MI among the subjects with DM, obesity, or both, the conditions associated with high oxidative stress.

语种英语
WOS记录号WOS:000226374000010
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61486
Collection北京大学第一临床医学院_心血管内科
作者单位1.Childrens Mem Res Ctr, Boston, MA USA
2.Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA
3.Childrens Mem Hosp, Mary Ann J Milburn Smith Child Hlth Res Program, Boston, MA USA
4.Peking Univ, Affiliated Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Ctr EcoGenet & Reprod Hlth, Dept Genet & Cell Biol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Li, JP,Wang, XB,Huo, Y,et al. PON1 polymorphism, diabetes mellitus, obesity, and risk of myocardial infarction: Modifying effect of diabetes mellitus and obesity on the association between PON1 polymorphism and myocardial infarction[J]. GENETICS IN MEDICINE,2005,7(1):58-63.
APA Li, JP.,Wang, XB.,Huo, Y.,Niu, TH.,Chen, CZ.,...&Xu, XP.(2005).PON1 polymorphism, diabetes mellitus, obesity, and risk of myocardial infarction: Modifying effect of diabetes mellitus and obesity on the association between PON1 polymorphism and myocardial infarction.GENETICS IN MEDICINE,7(1),58-63.
MLA Li, JP,et al."PON1 polymorphism, diabetes mellitus, obesity, and risk of myocardial infarction: Modifying effect of diabetes mellitus and obesity on the association between PON1 polymorphism and myocardial infarction".GENETICS IN MEDICINE 7.1(2005):58-63.
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