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学科主题基础医学
N-glycan profiles as tools in diagnosis of hepatocellular carcinoma and prediction of healthy human ageing
Vanhooren, Valerie1,2; Liu, Xue-En1,2,5; Franceschi, Claudio3; Gao, Chun-Fang4; Libert, Claude1,2; Contreras, Roland1,2; Chen, Cuiying1,2
关键词Liver cancer N-glycan Glycosylation Glycomics Ageing
刊名MECHANISMS OF AGEING AND DEVELOPMENT
2009
DOI10.1016/j.mad.2008.11.008
130期:1-2页:92-97
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Geriatrics & Gerontology
研究领域[WOS]Cell Biology ; Geriatrics & Gerontology
关键词[WOS]DNA-SEQUENCING EQUIPMENT ; HEPATITIS-B-VIRUS ; RHEUMATOID-ARTHRITIS ; PROTEIN GLYCOSYLATION ; GLYCOMIC CHANGES ; STANDARD ; IGG
英文摘要

Protein glycosylation, the most common form of co-translational modification of proteins, is the enzymatic addition of sugars or oligosaccharides (glycans) to proteins. Protein glycosylation increases the diversity of the functions of proteins encoded in the genome. The result is that different glycomes of the same protein may have different functional, kinetic or physical properties. The glycosylation pathway is largely regulated by the condition of the cells, which means that the Sugar chains can be altered by the physiological or pathophysiological condition of the cell. Thus, the type of glycans produced by cells, tissues, or organism could reflect their Current physiological state. We determined the N-glycan profiles of serum proteins by using DNA sequencer-based carbohydrate analytical profiling technology. We show that two N-glycan structures (NGA2F and NA2F) present in human blood glycoproteins change with ageing, and that one triantennary glycan (NA3Fb) is correlated with tumor stage in HCC patients. Therefore, examining alterations in serum glycan fingerprint by using our platform could be a suitable tool for monitoring the healthiness of ageing and for the follow-up of pathophysiological conditions Such as liver cancer. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000263398300014
项目编号01106205 ; 011 S605
资助机构Ghent University ; Flanders-China Bilateral project
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61488
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy
2.VIB, Dept Mol Biomed Res, B-9052 Ghent, Belgium
3.Univ Ghent, Dept Mol Biol, B-9052 Ghent, Belgium
4.Second Mil Med Univ, Eastern Hepatobiliary Hosp, Dept Lab Med, Shanghai 200433, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Vanhooren, Valerie,Liu, Xue-En,Franceschi, Claudio,et al. N-glycan profiles as tools in diagnosis of hepatocellular carcinoma and prediction of healthy human ageing[J]. MECHANISMS OF AGEING AND DEVELOPMENT,2009,130(1-2):92-97.
APA Vanhooren, Valerie.,Liu, Xue-En.,Franceschi, Claudio.,Gao, Chun-Fang.,Libert, Claude.,...&Chen, Cuiying.(2009).N-glycan profiles as tools in diagnosis of hepatocellular carcinoma and prediction of healthy human ageing.MECHANISMS OF AGEING AND DEVELOPMENT,130(1-2),92-97.
MLA Vanhooren, Valerie,et al."N-glycan profiles as tools in diagnosis of hepatocellular carcinoma and prediction of healthy human ageing".MECHANISMS OF AGEING AND DEVELOPMENT 130.1-2(2009):92-97.
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