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学科主题: 基础医学
题名:
N-glycan profiles as tools in diagnosis of hepatocellular carcinoma and prediction of healthy human ageing
作者: Vanhooren, Valerie1,2; Liu, Xue-En1,2,5; Franceschi, Claudio3; Gao, Chun-Fang4; Libert, Claude1,2; Contreras, Roland1,2; Chen, Cuiying1,2
关键词: Liver cancer ; N-glycan ; Glycosylation ; Glycomics ; Ageing
刊名: MECHANISMS OF AGEING AND DEVELOPMENT
发表日期: 2009
DOI: 10.1016/j.mad.2008.11.008
卷: 130, 期:1-2, 页:92-97
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Geriatrics & Gerontology
研究领域[WOS]: Cell Biology ; Geriatrics & Gerontology
关键词[WOS]: DNA-SEQUENCING EQUIPMENT ; HEPATITIS-B-VIRUS ; RHEUMATOID-ARTHRITIS ; PROTEIN GLYCOSYLATION ; GLYCOMIC CHANGES ; STANDARD ; IGG
英文摘要:

Protein glycosylation, the most common form of co-translational modification of proteins, is the enzymatic addition of sugars or oligosaccharides (glycans) to proteins. Protein glycosylation increases the diversity of the functions of proteins encoded in the genome. The result is that different glycomes of the same protein may have different functional, kinetic or physical properties. The glycosylation pathway is largely regulated by the condition of the cells, which means that the Sugar chains can be altered by the physiological or pathophysiological condition of the cell. Thus, the type of glycans produced by cells, tissues, or organism could reflect their Current physiological state. We determined the N-glycan profiles of serum proteins by using DNA sequencer-based carbohydrate analytical profiling technology. We show that two N-glycan structures (NGA2F and NA2F) present in human blood glycoproteins change with ageing, and that one triantennary glycan (NA3Fb) is correlated with tumor stage in HCC patients. Therefore, examining alterations in serum glycan fingerprint by using our platform could be a suitable tool for monitoring the healthiness of ageing and for the follow-up of pathophysiological conditions Such as liver cancer. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 01106205 ; 011 S605
项目资助者: Ghent University ; Flanders-China Bilateral project
WOS记录号: WOS:000263398300014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61488
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy
2.VIB, Dept Mol Biomed Res, B-9052 Ghent, Belgium
3.Univ Ghent, Dept Mol Biol, B-9052 Ghent, Belgium
4.Second Mil Med Univ, Eastern Hepatobiliary Hosp, Dept Lab Med, Shanghai 200433, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China

Recommended Citation:
Vanhooren, Valerie,Liu, Xue-En,Franceschi, Claudio,et al. N-glycan profiles as tools in diagnosis of hepatocellular carcinoma and prediction of healthy human ageing[J]. MECHANISMS OF AGEING AND DEVELOPMENT,2009,130(1-2):92-97.
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