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Effects of Lutein Supplement on Serum Inflammatory Cytokines, ApoE and Lipid Profiles in Early Atherosclerosis Population
Xu, Xian-Rong; Zou, Zhi-Yong; Xiao, Xin; Huang, Yang-Mu; Wang, Xun; Lin, Xiao-Ming
关键词Lutein Early atherosclerosis Cytokines ApoE LDL
刊名JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
2013
20期:2页:170-177
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]C-REACTIVE PROTEIN ; APOLIPOPROTEIN-E ; PLASMA CAROTENOIDS ; STATIN THERAPY ; RISK ; CHOLESTEROL ; DISEASE ; LDL ; INTERLEUKIN-6 ; ASTAXANTHIN
英文摘要

Aim: The purpose of this study was to determine the effects of lutein supplement on serum cytokines, apoE and lipoprotein profiles in early atherosclerosis population.

Methods: Early atherosclerosis patients (n=65) were randomized to receive placebo (A+P, n=31) or 20 mg/d lutein (A+L, n=34) for 3 months.

Results: Serum lutein increased significantly compared to baseline after lutein supplements in A+L group (p<0.001). Lutein supplements resulted in a significant decrease in serum interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) at 3 month in A+L group (p<0.05). Intragroup comparison revealed a significant difference in the changes of serum MCP-1 between A+L and A+P groups (p=0.021). The serum low-density lipoprotein (LDL) and triglyceride (TG) significantly decreased in A+L group (p<0.05). The changes in serum lutein were negatively associated with those in serum LDL in A+L group (r=-0.384, p=0.043), while no such relationship was observed in A+P group (r=0.087, p=0.685).

Conclusion: An increase in serum lutein after supplementation can reduce inflammatory cytokines and regulate serum lipids, which may pay important roles in early atherosclerosis.

语种英语
WOS记录号WOS:000317783500006
项目编号30972472
资助机构National Natural Science Foundation of China
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61490
专题北京大学公共卫生学院
北京大学公共卫生学院_全球卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xu, Xian-Rong,Zou, Zhi-Yong,Xiao, Xin,et al. Effects of Lutein Supplement on Serum Inflammatory Cytokines, ApoE and Lipid Profiles in Early Atherosclerosis Population[J]. JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS,2013,20(2):170-177.
APA Xu, Xian-Rong,Zou, Zhi-Yong,Xiao, Xin,Huang, Yang-Mu,Wang, Xun,&Lin, Xiao-Ming.(2013).Effects of Lutein Supplement on Serum Inflammatory Cytokines, ApoE and Lipid Profiles in Early Atherosclerosis Population.JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS,20(2),170-177.
MLA Xu, Xian-Rong,et al."Effects of Lutein Supplement on Serum Inflammatory Cytokines, ApoE and Lipid Profiles in Early Atherosclerosis Population".JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 20.2(2013):170-177.
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