IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科
学科主题临床医学
Detecting residual ischemia and identifying coronary artery disease after myocardial infarction using dobutamine technetium-99m-MIBI SPECT
Xu, CB; Chen, BX; Wang, WM; Tian, YW; Zhao, H; Jiang, BQ; Gao, BS; Qin, SL; Yue, MG; Qi, GY
关键词myocardial infarction dobutamine radionuclide imaging coronary artery disease residual ischemia
刊名CHINESE MEDICAL JOURNAL
2000-07-01
113期:7页:579-583
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]STRESS ECHOCARDIOGRAPHY ; SCINTIGRAPHY ; THERAPY
英文摘要

Objective To evaluate dobutamine technetium-99m methoxy isobutyl nitrile (sestamibi) single-photon emission computed tomography (Dobu-ECT) in detecting residual ischemia and identifying coronary vessel disease after myocardial infarction.

Methods Sixty-two patients with confirmed myocardial infarction were studied with Dobu-ECT at the time of coronary artery angiography. Dobutamine was administered intravenously in incremental rates from 5 to 40 mu g . kg(-1) . min(-1) at 5-minute intervals. At the highest infusion rate, 7.4 x 10(8) Bq (99)mTc-MIBI was injected intravenously, and tomographic imaging was performed after one hour. Resting images were taken after 24 hours, with a second dose of Tc-99m-MIBI.

Results The sensitivity of Dobu-ECT in detecting residual ischemia of myocardial infarction was 76%, which was higher than dobutamine electrocardiography (Dobu-ECG). Regardless of the single-, double- or triple-vessel diseases, Dobu-ECT was superior to Dobu-ECG in identifying residual ischemia (56% vs 4%, 86% vs 27%, 100% vs 47%, P < 0.01, respectively), The incidence of residual ischemia in patients receiving thrombolytic therapy was 67%, lower than patients without thrombolysis (72%) or those with an old myocardial infarction (94%). But the differences were not statistically significant. Dobu-ECT detected only 56% of ischemias in non-infarct related myocardium. Eighty-two percent of all significantly stenosed vessels were detected with Dobu-ECT, and 84% of patients with multivessel disease could be accurately identified. The sensitivity of Dobu-ECT was significantly greater for detecting severe stenosis over moderate stenosis. The sensitivity for detecting stenosis in the right coronary artery was greater than left anterior descending or left circumflex, but its specificity was lower.

Conclusion Dobu-ECT can identify residual ischemia, as well as its location and extent after myocardial infarction. Dobu-ECT can also accurately detect significantly stenosed vessels.

语种英语
WOS记录号WOS:000088641100001
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61492
专题北京大学第二临床医学院_心血管内科
作者单位1.Beijing Med Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
2.Beijing Med Univ, Peoples Hosp, Dept Nucl Med, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Xu, CB,Chen, BX,Wang, WM,et al. Detecting residual ischemia and identifying coronary artery disease after myocardial infarction using dobutamine technetium-99m-MIBI SPECT[J]. CHINESE MEDICAL JOURNAL,2000,113(7):579-583.
APA Xu, CB.,Chen, BX.,Wang, WM.,Tian, YW.,Zhao, H.,...&Qi, GY.(2000).Detecting residual ischemia and identifying coronary artery disease after myocardial infarction using dobutamine technetium-99m-MIBI SPECT.CHINESE MEDICAL JOURNAL,113(7),579-583.
MLA Xu, CB,et al."Detecting residual ischemia and identifying coronary artery disease after myocardial infarction using dobutamine technetium-99m-MIBI SPECT".CHINESE MEDICAL JOURNAL 113.7(2000):579-583.
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