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Variations in parametrial white adipose tissue mass during the mouse estrous cycle: relationship with the expression of peroxisome proliferator-activated receptor-gamma and retinoic acid receptor-alpha
Gui, Yaoting; Cai, Zhiming; Silha, Josef V.; Murphy, Liam J.
关键词adipose tissues estrous cycle mouse PPAR gamma RXR alpha
刊名CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
2006-08-01
DOI10.1139/Y06-032
84期:8-9页:887-892
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Physiology
研究领域[WOS]Pharmacology & Pharmacy ; Physiology
关键词[WOS]INSULIN-RESISTANCE ; X-RECEPTOR ; CROSS-TALK ; MICE ; OBESITY ; GLUCOSE ; LEPTIN ; RATS
英文摘要

Estrogen and progestin participate in the regulation of adipose tissue metabolism, and peroxisome proliferator-activated receptor-gamma (PPAR gamma) and retinoic acid receptor-alpha (RXR alpha) are absolutely required for adipose tissue development. The present study is to investigate the changes in parametrial fat mass and expression of PPAR gamma and RXR alpha during estrous cycle in mice. Parametrial white adipose tissues (WAT), inter-scapula brown adipose tissues, and uteri from female mice were weighed. Blood samples were collected for the measurement of 17 beta-estradiol and progesterone levels. An RNase protection assay and Western blot analysis were used to compare the expression of PPAR gamma and RXR alpha in adipose tissue. The mass of parametrial WAT in diestrus was significantly higher compared with estrus. However, there is no significant difference on the mass of brown adipose tissues during estrous cycle. The expression of PPAR gamma in WAT in diestrus was significantly higher than that in estrus. The expression of RXR alpha during estrous cycle was unchanged in both white and brown adipose tissues. In conclusion, the variation in parametrial WAT mass during the mouse estrous cycle correlates with changes in the expression of PPAR gamma in WAT.

语种英语
WOS记录号WOS:000242210800009
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61493
专题北京大学深圳医院_生殖医学科
作者单位1.Univ Manitoba, Dept Physiol, Winnipeg, MB R3E 0W3, Canada
2.Peking Univ, Shenzhen Hosp, Ctr Reprod Med, Shenzhen 518036, Peoples R China
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Gui, Yaoting,Cai, Zhiming,Silha, Josef V.,et al. Variations in parametrial white adipose tissue mass during the mouse estrous cycle: relationship with the expression of peroxisome proliferator-activated receptor-gamma and retinoic acid receptor-alpha[J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY,2006,84(8-9):887-892.
APA Gui, Yaoting,Cai, Zhiming,Silha, Josef V.,&Murphy, Liam J..(2006).Variations in parametrial white adipose tissue mass during the mouse estrous cycle: relationship with the expression of peroxisome proliferator-activated receptor-gamma and retinoic acid receptor-alpha.CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY,84(8-9),887-892.
MLA Gui, Yaoting,et al."Variations in parametrial white adipose tissue mass during the mouse estrous cycle: relationship with the expression of peroxisome proliferator-activated receptor-gamma and retinoic acid receptor-alpha".CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 84.8-9(2006):887-892.
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