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学科主题: 药学
题名:
Design and fabrication of multivalent Gal-containing quantum dots and study of its interactions with asialoglycoprotein receptor (ASGP-R)
作者: Yang, Yang2; Zhao, Yue-Tao2; Yan, Ting-Ting1; Yu, Min3,4; Sha, Yin-Lin3,4; Zhao, Zhi-Hui1; Li, Zhong-Jun2
刊名: TETRAHEDRON LETTERS
发表日期: 2010-08-11
DOI: 10.1016/j.tetlet.2010.06.002
卷: 51, 期:32, 页:4182-4185
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: IN-VIVO ; GOLD NANOPARTICLES ; LIVER ; HEPATOCYTES ; DELIVERY ; LIGANDS ; LECTINS ; BINDING ; VITRO ; DRUG
英文摘要:

Multivalent lactose (Lac-QDs)- and galactose (Gal-QDs)- coated CdSeS-ZnS core-shell quantum dots (QDs) were prepared. The formula of the glyco-QDs was determined by nuclear magnetic resonance (NMR) and inductively coupled plasma-optical emission spectrometry (ICP-OES). The uptake of the Gal-containing glyco-QDs by HepG2 cells was investigated. Flow cytometry (FCM) and fluorescence microscopy analysis indicated that the uptake is receptor mediated and selective. The prepared multivalent glyco-QDs could be used to mimic the oligosaccharides in the study of hepatic endocytosis. Furthermore, this type of glyco-QDs can be used as a useful fluorescent probe in cell imaging and analysis of carbohydrate-protein interactions. (C) 2010 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 90713004 ; 20973008 ; 2009ZX09103-044
项目资助者: Natural Science Foundation of China ; State New Drug Innovation ; State Key Laboratory of Natural and Biomimetic Drugs and Peking University
WOS记录号: WOS:000280345800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61496
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Nanjing Normal Univ, Coll Life Sci, Nanjing 210046, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Peking Univ, Single Mol & Nanobiol Lab, Dept Biophys, Sch Basic Med Sci, Beijing 100191, Peoples R China
4.Peking Univ, Biomed X Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Yang,Zhao, Yue-Tao,Yan, Ting-Ting,et al. Design and fabrication of multivalent Gal-containing quantum dots and study of its interactions with asialoglycoprotein receptor (ASGP-R)[J]. TETRAHEDRON LETTERS,2010,51(32):4182-4185.
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