IR@PKUHSC  > 北京大学药学院
学科主题药学
Vanadyl acetylacetonate upregulates PPAR gamma and adiponectin expression in differentiated rat adipocytes
Wu, Yaling1,2; Huang, Meiling1,2; Zhao, Pan1,2; Yang, Xiaoda1,2
关键词Vanadium Adiponectin Adipocytes Peroxisome-proliferator-activated receptor gamma p38 mitogen-activated protein kinase
刊名JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
2013-08-01
DOI10.1007/s00775-013-1007-3
18期:6页:623-631
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear
资助者National Natural Science Foundation of China ; Research Fund for Doctoral Program of Higher Education of China ; National Natural Science Foundation of China ; Research Fund for Doctoral Program of Higher Education of China
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]GENE-EXPRESSION ; SKELETAL-MUSCLE ; OB/OB MICE ; IN-VITRO ; INSULIN ; PROTEIN ; COMPLEX ; MULTIMERIZATION ; MECHANISMS ; RECEPTORS
英文摘要

Vanadium compounds are promising agents in the therapeutic treatment of diabetes mellitus, but their mechanism of action has not been fully elucidated. The current work investigated the effects of vanadyl acetylacetonate, VO(acac)(2), on peroxisome-proliferator-activated receptor gamma (PPAR gamma) and adiponectin, which are important targets of antidiabetic drugs. The experimental results revealed that vanadyl complexes increased the expression and multimerization of adiponectin in differentiated rat adipocytes. VO(acac)(2) caused activation of p38 mitogen-activated protein kinase (MAPK) and AMP-activated protein kinase (AMPK) and elevation of PPAR gamma levels. The specific inhibitors SB203580 (p38 MAPK inhibitor) and T0070907 (PPAR gamma inhibitor) decreased the expression of adiponectin; however, compound C (AMPK inhibitor) did not significantly reduce the expression of adiponectin. In addition, vanadyl complexes induced protein-protein interaction between PPAR gamma and a vanadium-binding chaperone, heat shock protein 60 kDa. Overall, our results suggest that vanadyl complexes may upregulate PPAR gamma by suppressing PPAR gamma degradation, and thus stimulate adiponectin expression and multimerization. The present work has provided new insights into the mechanism of the antidiabetic actions of vanadium compounds.

语种英语
所属项目编号21271012 ; 20971008
资助者National Natural Science Foundation of China ; Research Fund for Doctoral Program of Higher Education of China ; National Natural Science Foundation of China ; Research Fund for Doctoral Program of Higher Education of China
WOS记录号WOS:000322188100004
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61498
专题北京大学药学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Labs Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wu, Yaling,Huang, Meiling,Zhao, Pan,et al. Vanadyl acetylacetonate upregulates PPAR gamma and adiponectin expression in differentiated rat adipocytes[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,2013,18(6):623-631.
APA Wu, Yaling,Huang, Meiling,Zhao, Pan,&Yang, Xiaoda.(2013).Vanadyl acetylacetonate upregulates PPAR gamma and adiponectin expression in differentiated rat adipocytes.JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,18(6),623-631.
MLA Wu, Yaling,et al."Vanadyl acetylacetonate upregulates PPAR gamma and adiponectin expression in differentiated rat adipocytes".JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 18.6(2013):623-631.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wu, Yaling]的文章
[Huang, Meiling]的文章
[Zhao, Pan]的文章
百度学术
百度学术中相似的文章
[Wu, Yaling]的文章
[Huang, Meiling]的文章
[Zhao, Pan]的文章
必应学术
必应学术中相似的文章
[Wu, Yaling]的文章
[Huang, Meiling]的文章
[Zhao, Pan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。