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学科主题: 临床医学
题名:
Volume overhydration is related to endothelial dysfunction in continuous ambulatory peritoneal dialysis patients
作者: Cheng, Li-Tao1; Gao, Yan-Li1,2; Qin, Chao1,3; Tian, Jun-Ping1,4; Gu, Yue1; Bi, Shu-Hong1; Tang, Wen1; Wang, Tao1
关键词: volume status ; endothelial function ; flow-mediated dilatation
刊名: PERITONEAL DIALYSIS INTERNATIONAL
发表日期: 2008-07-01
卷: 28, 期:4, 页:397-402
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: FLOW-MEDIATED VASODILATION ; BLOOD-PRESSURE ; BRACHIAL-ARTERY ; FLUID STATUS ; ESSENTIAL-HYPERTENSION ; HYPERPARATHYROIDISM ; DILATATION ; DISEASE
英文摘要:

Objective: In dialysis patients, volume overhydration is common and is related to increased risk of cardiovascular morbidity and mortality. However, it remains unclear whether volume overload imposes those detrimental effects through endothelial dysfunction.

Methods: In this cross-sectional study, 81 stable patients on continuous ambulatory peritoneal dialysis in a single center were recruited. Volume status was evaluated by extracellular water, assessed by bioimpedance analysis, and normalized to individual height ( nECW). Endothelial function was estimated by endothelial-dependent flow- mediated dilatation ( FMD) of the brachial artery and expressed as percentage change relative to baseline diameter.

Results: There were 37 male and 44 female patients ( mean age 61 +/- 12 years, dialysis vintage 20 +/- 23 months). FMD in female patients was significantly higher than that in male patients ( 9.17% +/- 6.23% vs 6.31% +/- 5.01%, p < 0.05). FMD was negatively correlated with weight ( r = -0.308, p < 0.01), body mass index ( r = -0.242, p < 0.05), systolic blood pressure ( r = -0.228, p < 0.05), ECW ( r = -0.404, p < 0.001), and nECW ( r = -0.418, p < 0.001). No correlation was found between FMD and other variables. In multiple stepwise regression analysis, calcium x phosphate product ( beta = 0.422, p < 0.001), nECW ( beta = -0.343, p < 0.01), and dialysis vintage (beta = -0.237, p < 0.05) were independent determinants of FMD ( adjusted R-2 = 0.327 for this model).

Conclusion: There was independent correlation between index of volume status and FMD, and higher nECW was related to worse endothelial function. The results of this study may help us understand the underlying mechanism of volume overhydration leading to increased cardiovascular morbidity and mortality in dialysis patients.

语种: 英语
WOS记录号: WOS:000256889800015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61500
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Div Nephrol, Beijing 100083, Peoples R China
2.Guangzhou Univ Chinese Tradit Med, Clin Coll 2, Guangzhou, Guangdong, Peoples R China
3.Shandong Univ, Qilu Hosp, Div Nephrol, Jinan 250100, Peoples R China
4.Capital Univ Med Sci, Beijing Tiantan Hosp, Div Cardiol, Beijing, Peoples R China

Recommended Citation:
Cheng, Li-Tao,Gao, Yan-Li,Qin, Chao,et al. Volume overhydration is related to endothelial dysfunction in continuous ambulatory peritoneal dialysis patients[J]. PERITONEAL DIALYSIS INTERNATIONAL,2008,28(4):397-402.
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