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Clozapine use in schizophrenia: findings of the Research on Asia Psychotropic Prescription (REAP) studies from 2001 to 2009
Xiang, Yu-Tao1,2; Wang, Chuan-Yue2; Si, Tian-Mei3; Lee, Edwin H. M.1; He, Yan-Ling4; Ungvari, Gabor S.5; Chiu, Helen F. K.1; Shinfuku, Naotaka6; Yang, Shu-Yu7,8; Chong, Mian-Yoon9,10; Kua, Ee-Heok11; Fujii, Senta12; Sim, Kang13; Yong, Michael K. H.13; Trivedi, Jitendra K.14; Chung, Eun-Kee15; Udomratn, Pichet16; Chee, Kok-Yoon17; Sartorius, Norman18; Dixon, Lisa B.19,20; Kreyenbuhl, Julie A.19,20; Tan, Chay-Hoon11
关键词clozapine prescription patterns schizophrenia
刊名AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
2011-11-01
DOI10.3109/00048674.2011.607426
45期:11页:968-975
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]ATYPICAL ANTIPSYCHOTICS ; CHLORPROMAZINE ; MANAGEMENT ; DISORDER ; HEALTH ; TRIAL
英文摘要

Objective: Optimizing treatment and outcomes for people with schizophrenia requires understanding of how evidence-based treatments are utilized. Clozapine is the most effective antipsychotic drug for treatment-refractory schizophrenia, but few studies have investigated trends and patterns of its use over time internationally. This study examined the prescription patterns of clozapine and its demographic and clinical correlates in Asia from 2001 to 2009.

Method: Clozapine prescriptions were collected in a sample of 6761 hospitalized schizophrenia patients in nine Asian countries and regions using a standardized protocol and data collection procedure.

Results: Overall, the proportion of patients receiving clozapine prescriptions was stable across the three surveys from 2001 to 2009, ranging from 14.5% to 15.9%. However, the rates and patterns observed within different regions and countries at each survey differed considerably. Clozapine use decreased significantly over time in China, while it increased in Korea and Singapore. Multiple logistic regression analysis revealed that patients taking clozapine were significantly younger, had a higher dose of antipsychotic drugs in chlorpromazine equivalents, were more likely to be female, had fewer extrapyramidal symptoms, and had more negative symptoms, admissions and weight gain in the past month than those not receiving clozapine.

Conclusion: The variability in overall rates and changes in prescription rates over time in these samples suggest that factors other than psychopharmacological principles play an important role in determining the use of clozapine in schizophrenia in Asia.

语种英语
WOS记录号WOS:000296457400010
项目编号81171270 ; 30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
资助机构National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; Chinese University of Hong Kong ; Institute of Mental Health, Singapore ; Taiwan Bureau of National Health Insurance ; Chang Gung Memorial Hospital ; Taipei City Government, Taiwan
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61506
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Chinese Univ Hong Kong, Dept Psychiat, Multictr, Tai Po Hosp, Tai Po, Hong Kong, Peoples R China
3.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
4.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai 200030, Peoples R China
5.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
6.Seinan Gakuin Univ, Sch Human Sci, Fukuoka, Japan
7.Taipei City Hosp, Clin Pharm Sect, Taipei, Taiwan
8.Kaohsiung Med Univ, Kaohsiung, Taiwan
9.Kaohsiung Chang Gung Mem Hosp, Kaohsiung, Taiwan
10.Chang Gung Univ, Sch Med, Kaohsiung, Taiwan
11.Natl Univ Singapore, Singapore 117548, Singapore
12.HITS, Kobe, Hyogo, Japan
13.Inst Mental Hlth, Buangkok View, Singapore
14.CSM Med Univ UP, Dept Psychiat, Lucknow, Uttar Pradesh, India
15.Natl Seoul Hosp, Seoul, South Korea
16.Prince Songkla Univ, Dept Psychiat, Fac Med, Hat Yai, Thailand
17.Kuala Lumpur Hosp, Dept Psychiat & Mental Hlth, Tunku Abdul Rahman Inst Neurosci, Kuala Lumpur, Malaysia
18.Assoc Improvement Mental Hlth Programs, Geneva, Switzerland
19.Univ Maryland, Div Res Serv, Dept Psychiat, Sch Med, Baltimore, MD 21201 USA
20.MIRECC, Vet Adm Capitol Healthcare Network VISN 5, Baltimore, MD USA
推荐引用方式
GB/T 7714
Xiang, Yu-Tao,Wang, Chuan-Yue,Si, Tian-Mei,et al. Clozapine use in schizophrenia: findings of the Research on Asia Psychotropic Prescription (REAP) studies from 2001 to 2009[J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY,2011,45(11):968-975.
APA Xiang, Yu-Tao.,Wang, Chuan-Yue.,Si, Tian-Mei.,Lee, Edwin H. M..,He, Yan-Ling.,...&Tan, Chay-Hoon.(2011).Clozapine use in schizophrenia: findings of the Research on Asia Psychotropic Prescription (REAP) studies from 2001 to 2009.AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY,45(11),968-975.
MLA Xiang, Yu-Tao,et al."Clozapine use in schizophrenia: findings of the Research on Asia Psychotropic Prescription (REAP) studies from 2001 to 2009".AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY 45.11(2011):968-975.
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