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学科主题: 精神卫生
题名:
Clozapine use in schizophrenia: findings of the Research on Asia Psychotropic Prescription (REAP) studies from 2001 to 2009
作者: Xiang, Yu-Tao1,2; Wang, Chuan-Yue2; Si, Tian-Mei3; Lee, Edwin H. M.1; He, Yan-Ling4; Ungvari, Gabor S.5; Chiu, Helen F. K.1; Shinfuku, Naotaka6; Yang, Shu-Yu7,8; Chong, Mian-Yoon9,10; Kua, Ee-Heok11; Fujii, Senta12; Sim, Kang13; Yong, Michael K. H.13; Trivedi, Jitendra K.14; Chung, Eun-Kee15; Udomratn, Pichet16; Chee, Kok-Yoon17; Sartorius, Norman18; Dixon, Lisa B.19,20; Kreyenbuhl, Julie A.19,20; Tan, Chay-Hoon11
关键词: clozapine ; prescription patterns ; schizophrenia
刊名: AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
发表日期: 2011-11-01
DOI: 10.3109/00048674.2011.607426
卷: 45, 期:11, 页:968-975
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: ATYPICAL ANTIPSYCHOTICS ; CHLORPROMAZINE ; MANAGEMENT ; DISORDER ; HEALTH ; TRIAL
英文摘要:

Objective: Optimizing treatment and outcomes for people with schizophrenia requires understanding of how evidence-based treatments are utilized. Clozapine is the most effective antipsychotic drug for treatment-refractory schizophrenia, but few studies have investigated trends and patterns of its use over time internationally. This study examined the prescription patterns of clozapine and its demographic and clinical correlates in Asia from 2001 to 2009.

Method: Clozapine prescriptions were collected in a sample of 6761 hospitalized schizophrenia patients in nine Asian countries and regions using a standardized protocol and data collection procedure.

Results: Overall, the proportion of patients receiving clozapine prescriptions was stable across the three surveys from 2001 to 2009, ranging from 14.5% to 15.9%. However, the rates and patterns observed within different regions and countries at each survey differed considerably. Clozapine use decreased significantly over time in China, while it increased in Korea and Singapore. Multiple logistic regression analysis revealed that patients taking clozapine were significantly younger, had a higher dose of antipsychotic drugs in chlorpromazine equivalents, were more likely to be female, had fewer extrapyramidal symptoms, and had more negative symptoms, admissions and weight gain in the past month than those not receiving clozapine.

Conclusion: The variability in overall rates and changes in prescription rates over time in these samples suggest that factors other than psychopharmacological principles play an important role in determining the use of clozapine in schizophrenia in Asia.

语种: 英语
所属项目编号: 81171270 ; 30800367 ; 30770776 ; 2008B59 ; 2041454 ; CRC 249/2008 ; DOH92-NH-1025 ; CMRPG83043 ; 97001-62-010
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; Chinese University of Hong Kong ; Institute of Mental Health, Singapore ; Taiwan Bureau of National Health Insurance ; Chang Gung Memorial Hospital ; Taipei City Government, Taiwan
WOS记录号: WOS:000296457400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61506
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Chinese Univ Hong Kong, Dept Psychiat, Multictr, Tai Po Hosp, Tai Po, Hong Kong, Peoples R China
3.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
4.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai 200030, Peoples R China
5.Univ Notre Dame Australia, Marian Ctr, Perth, WA, Australia
6.Seinan Gakuin Univ, Sch Human Sci, Fukuoka, Japan
7.Taipei City Hosp, Clin Pharm Sect, Taipei, Taiwan
8.Kaohsiung Med Univ, Kaohsiung, Taiwan
9.Kaohsiung Chang Gung Mem Hosp, Kaohsiung, Taiwan
10.Chang Gung Univ, Sch Med, Kaohsiung, Taiwan
11.Natl Univ Singapore, Singapore 117548, Singapore
12.HITS, Kobe, Hyogo, Japan
13.Inst Mental Hlth, Buangkok View, Singapore
14.CSM Med Univ UP, Dept Psychiat, Lucknow, Uttar Pradesh, India
15.Natl Seoul Hosp, Seoul, South Korea
16.Prince Songkla Univ, Dept Psychiat, Fac Med, Hat Yai, Thailand
17.Kuala Lumpur Hosp, Dept Psychiat & Mental Hlth, Tunku Abdul Rahman Inst Neurosci, Kuala Lumpur, Malaysia
18.Assoc Improvement Mental Hlth Programs, Geneva, Switzerland
19.Univ Maryland, Div Res Serv, Dept Psychiat, Sch Med, Baltimore, MD 21201 USA
20.MIRECC, Vet Adm Capitol Healthcare Network VISN 5, Baltimore, MD USA

Recommended Citation:
Xiang, Yu-Tao,Wang, Chuan-Yue,Si, Tian-Mei,et al. Clozapine use in schizophrenia: findings of the Research on Asia Psychotropic Prescription (REAP) studies from 2001 to 2009[J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY,2011,45(11):968-975.
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