北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 病理学系  > 期刊论文
学科主题: 基础医学
题名:
Succinate dehydrogenase B: a new prognostic biomarker in clear cell renal cell carcinoma
作者: Cornejo, Kristine M.1,2; Lu, Min1,2,3; Yang, Ping1,2,4; Wu, Shulin1,2; Cai, Chao5,6; Zhong, Wei-de5; Olumi, Aria6; Young, Robert H.1,2; Wu, Chin-Lee1,2,6
关键词: Renal cell carcinoma ; Clear cell ; Succinate dehydrogenase B ; Immunohistochemistry ; Oncocytoma ; Prognosis
刊名: HUMAN PATHOLOGY
发表日期: 2015-06-01
DOI: 10.1016/j.humpath.2015.02.013
卷: 46, 期:6, 页:820-826
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: TUBEROUS SCLEROSIS COMPLEX ; GERMLINE SDHB ; INTERNATIONAL SOCIETY ; PARAGANGLIOMA ; MUTATIONS ; NEOPLASIA ; GENE
英文摘要:

Succinate dehydrogenase B (SDHB) is a mitochondrial enzyme complex subunit. Loss of SDHB protein expression has been found to correlate with SDHx gene mutations. Little is known about its expression in subtypes of renal cell carcinoma (RCC) and whether it is a prognostic indicator. Four hundred fifty renal epithelial neoplasms were analyzed for SDHB, comprising clear cell RCC (CCRCC) (n = 240), papillary RCC (n = 84), chromophobe RCC (n = 49), renal oncocytoma (n = 47), clear cell papillary RCC (CCPRCC) (n = 19), and von Hippel-Lindau (VHL) associated CCPRCC-like tumors (n = 11). Succinate dehydrogenase B expression was graded based upon staining intensity using a 4-tiered system (0-3+), in which 3+ was strongest and complete absence was 0. Neoplasms were further categorized based upon staining extent into SDHB weak (1+-2+) and strong (3+). Succinate dehydrogenase B was strongly preserved in 131(55%) of 240 CCRCCs, 84 (100%) of 84 papillary RCCs, 49 (100%) of 49 chromophobe RCCs, 1(5%) of 19 CCPRCC, 5 (45%) of 11 VHL-associated CCPRCC-like tumors, and 47 (100%) of 47 renal oncocytomas. The remaining 109 CCRCCs, 18 CCPRCCs, and 6 VHL-associated CCPRCC-like tumors had weak but preserved SDHB. Succinate dehydrogenase B expression in CCRCCs with high International Society of Urological Pathology nucleolar grade (G3-G4) correlated significantly with survival (log-rank, P=.0004). Succinate dehydrogenase B is variably expressed in RCCs with clear cell morphology and strongly preserved in most other neoplasms. Therefore, weak staining, particularly in clear neoplasms, should not be misinterpreted as negative. Finally, SDHB expression in CCRCCs with high nucleolar grade (G3-G4) is significantly associated with survival, indicating it may be both a diagnostic and prognostic marker in RCC. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: CA120964
项目资助者: National Institutes of Health grant
WOS记录号: WOS:000354593300004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61519
Appears in Collections:基础医学院_病理学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Succinate dehydrogenase B a new prognostic biomarker in clear cell renal cell carcinoma.pdf(2365KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Massachusetts Gen Hosp, James Homer Wright Pathol Labs, Boston, MA 02114 USA
2.Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
3.Massachusetts Gen Hosp, Dept Urol, Boston, MA 02114 USA
4.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pathol, Beijing 100871, Peoples R China
5.Sun Yat Sen Univ, Ctr Canc, Dept Pathol, Guangzhou 510275, Guangdong, Peoples R China
6.Gudngzhou Med Coll, Guangzhou Municipal Peoples Hosp 1, Dept Urol, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Cornejo, Kristine M.,Lu, Min,Yang, Ping,et al. Succinate dehydrogenase B: a new prognostic biomarker in clear cell renal cell carcinoma[J]. HUMAN PATHOLOGY,2015,46(6):820-826.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Cornejo, Kristine M.]'s Articles
[Lu, Min]'s Articles
[Yang, Ping]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Cornejo, Kristine M.]‘s Articles
[Lu, Min]‘s Articles
[Yang, Ping]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace