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学科主题基础医学
Succinate dehydrogenase B: a new prognostic biomarker in clear cell renal cell carcinoma
Cornejo, Kristine M.1,2; Lu, Min1,2,3; Yang, Ping1,2,4; Wu, Shulin1,2; Cai, Chao5,6; Zhong, Wei-de5; Olumi, Aria6; Young, Robert H.1,2; Wu, Chin-Lee1,2,6
关键词Renal cell carcinoma Clear cell Succinate dehydrogenase B Immunohistochemistry Oncocytoma Prognosis
刊名HUMAN PATHOLOGY
2015-06-01
DOI10.1016/j.humpath.2015.02.013
46期:6页:820-826
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]TUBEROUS SCLEROSIS COMPLEX ; GERMLINE SDHB ; INTERNATIONAL SOCIETY ; PARAGANGLIOMA ; MUTATIONS ; NEOPLASIA ; GENE
英文摘要

Succinate dehydrogenase B (SDHB) is a mitochondrial enzyme complex subunit. Loss of SDHB protein expression has been found to correlate with SDHx gene mutations. Little is known about its expression in subtypes of renal cell carcinoma (RCC) and whether it is a prognostic indicator. Four hundred fifty renal epithelial neoplasms were analyzed for SDHB, comprising clear cell RCC (CCRCC) (n = 240), papillary RCC (n = 84), chromophobe RCC (n = 49), renal oncocytoma (n = 47), clear cell papillary RCC (CCPRCC) (n = 19), and von Hippel-Lindau (VHL) associated CCPRCC-like tumors (n = 11). Succinate dehydrogenase B expression was graded based upon staining intensity using a 4-tiered system (0-3+), in which 3+ was strongest and complete absence was 0. Neoplasms were further categorized based upon staining extent into SDHB weak (1+-2+) and strong (3+). Succinate dehydrogenase B was strongly preserved in 131(55%) of 240 CCRCCs, 84 (100%) of 84 papillary RCCs, 49 (100%) of 49 chromophobe RCCs, 1(5%) of 19 CCPRCC, 5 (45%) of 11 VHL-associated CCPRCC-like tumors, and 47 (100%) of 47 renal oncocytomas. The remaining 109 CCRCCs, 18 CCPRCCs, and 6 VHL-associated CCPRCC-like tumors had weak but preserved SDHB. Succinate dehydrogenase B expression in CCRCCs with high International Society of Urological Pathology nucleolar grade (G3-G4) correlated significantly with survival (log-rank, P=.0004). Succinate dehydrogenase B is variably expressed in RCCs with clear cell morphology and strongly preserved in most other neoplasms. Therefore, weak staining, particularly in clear neoplasms, should not be misinterpreted as negative. Finally, SDHB expression in CCRCCs with high nucleolar grade (G3-G4) is significantly associated with survival, indicating it may be both a diagnostic and prognostic marker in RCC. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000354593300004
项目编号CA120964
资助机构National Institutes of Health grant
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61519
专题北京大学基础医学院_病理学系
北京大学护理学院_护理学院
作者单位1.Massachusetts Gen Hosp, James Homer Wright Pathol Labs, Boston, MA 02114 USA
2.Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
3.Massachusetts Gen Hosp, Dept Urol, Boston, MA 02114 USA
4.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pathol, Beijing 100871, Peoples R China
5.Sun Yat Sen Univ, Ctr Canc, Dept Pathol, Guangzhou 510275, Guangdong, Peoples R China
6.Gudngzhou Med Coll, Guangzhou Municipal Peoples Hosp 1, Dept Urol, Guangzhou, Guangdong, Peoples R China
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Cornejo, Kristine M.,Lu, Min,Yang, Ping,et al. Succinate dehydrogenase B: a new prognostic biomarker in clear cell renal cell carcinoma[J]. HUMAN PATHOLOGY,2015,46(6):820-826.
APA Cornejo, Kristine M..,Lu, Min.,Yang, Ping.,Wu, Shulin.,Cai, Chao.,...&Wu, Chin-Lee.(2015).Succinate dehydrogenase B: a new prognostic biomarker in clear cell renal cell carcinoma.HUMAN PATHOLOGY,46(6),820-826.
MLA Cornejo, Kristine M.,et al."Succinate dehydrogenase B: a new prognostic biomarker in clear cell renal cell carcinoma".HUMAN PATHOLOGY 46.6(2015):820-826.
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