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Performance of HbA(1c) for detecting newly diagnosed diabetes and pre-diabetes in Chinese communities living in Beijing
Zhou, X. H.2; Ji, L. N.1; Luo, Y. Y.; Zhang, X. Y.; Han, X. Y.; Qiao, Q.2,3
关键词diabetes glycated haemoglobin screening
刊名DIABETIC MEDICINE
2009-12-01
DOI10.1111/j.1464-5491.2009.02831.x
26期:12页:1262-1268
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]IMPAIRED GLUCOSE-TOLERANCE ; FASTING PLASMA-GLUCOSE ; FOLLOW-UP ; NATURAL-HISTORY ; US POPULATION ; LIFE-STYLE ; MELLITUS ; RISK ; INTERVENTION ; HEMOGLOBIN
英文摘要

Aim

To determine the performance of glycated haemoglobin (HbA(1c)) as a screening tool for detecting newly diagnosed diabetes (NDM) and pre-diabetes.

Methods

A diabetes survey was conducted in Beijing among community dwellers who were willing to participate in the survey. Included in the survey were 903 individuals aged 21-79 years without previously diagnosed diabetes and in whom HbA(1c) and other required covariates had been measured. NDM and pre-diabetes (impaired glucose tolerance + impaired fasting glucose) were defined according to the World Health Organization 1999 criteria based on 75-g oral glucose tolerance test. Receiver operating characteristic curve (ROC) was plotted to determine the performance of HbA(1c).

Results

The prevalence of NDM and pre-diabetes was 11.1% and 22.4%, respectively. At an optimal HbA(1c) cut-off point of >= 6.0%, the test gave a sensitivity of 80.0% and a specificity of 89.8% for diagnosing NDM; at an optimal cut-off point of >= 5.7%, the sensitivity was 59.4% and specificity 73.9% for diagnosing pre-diabetes. Individuals with HbA(1c)>= 6.0% tended to be more obese than those with HbA(1c) < 6.0%, but blood pressure and lipid profiles did not differ between the two groups.

Conclusions

HbA(1c) as a single screening test is adequate to detect newly diagnosed diabetes but is not able to identify pre-diabetes in this obese Chinese population.

语种英语
WOS记录号WOS:000272161900012
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61526
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Ctr Diabet, Beijing 100044, Peoples R China
2.Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
3.Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
推荐引用方式
GB/T 7714
Zhou, X. H.,Ji, L. N.,Luo, Y. Y.,et al. Performance of HbA(1c) for detecting newly diagnosed diabetes and pre-diabetes in Chinese communities living in Beijing[J]. DIABETIC MEDICINE,2009,26(12):1262-1268.
APA Zhou, X. H.,Ji, L. N.,Luo, Y. Y.,Zhang, X. Y.,Han, X. Y.,&Qiao, Q..(2009).Performance of HbA(1c) for detecting newly diagnosed diabetes and pre-diabetes in Chinese communities living in Beijing.DIABETIC MEDICINE,26(12),1262-1268.
MLA Zhou, X. H.,et al."Performance of HbA(1c) for detecting newly diagnosed diabetes and pre-diabetes in Chinese communities living in Beijing".DIABETIC MEDICINE 26.12(2009):1262-1268.
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