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学科主题: 临床医学
题名:
Performance of HbA(1c) for detecting newly diagnosed diabetes and pre-diabetes in Chinese communities living in Beijing
作者: Zhou, X. H.2; Ji, L. N.1; Luo, Y. Y.; Zhang, X. Y.; Han, X. Y.; Qiao, Q.2,3
关键词: diabetes ; glycated haemoglobin ; screening
刊名: DIABETIC MEDICINE
发表日期: 2009-12-01
DOI: 10.1111/j.1464-5491.2009.02831.x
卷: 26, 期:12, 页:1262-1268
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: IMPAIRED GLUCOSE-TOLERANCE ; FASTING PLASMA-GLUCOSE ; FOLLOW-UP ; NATURAL-HISTORY ; US POPULATION ; LIFE-STYLE ; MELLITUS ; RISK ; INTERVENTION ; HEMOGLOBIN
英文摘要:

Aim

To determine the performance of glycated haemoglobin (HbA(1c)) as a screening tool for detecting newly diagnosed diabetes (NDM) and pre-diabetes.

Methods

A diabetes survey was conducted in Beijing among community dwellers who were willing to participate in the survey. Included in the survey were 903 individuals aged 21-79 years without previously diagnosed diabetes and in whom HbA(1c) and other required covariates had been measured. NDM and pre-diabetes (impaired glucose tolerance + impaired fasting glucose) were defined according to the World Health Organization 1999 criteria based on 75-g oral glucose tolerance test. Receiver operating characteristic curve (ROC) was plotted to determine the performance of HbA(1c).

Results

The prevalence of NDM and pre-diabetes was 11.1% and 22.4%, respectively. At an optimal HbA(1c) cut-off point of >= 6.0%, the test gave a sensitivity of 80.0% and a specificity of 89.8% for diagnosing NDM; at an optimal cut-off point of >= 5.7%, the sensitivity was 59.4% and specificity 73.9% for diagnosing pre-diabetes. Individuals with HbA(1c)>= 6.0% tended to be more obese than those with HbA(1c) < 6.0%, but blood pressure and lipid profiles did not differ between the two groups.

Conclusions

HbA(1c) as a single screening test is adequate to detect newly diagnosed diabetes but is not able to identify pre-diabetes in this obese Chinese population.

语种: 英语
所属项目编号: 2006CB503900 ; 2006AA02A409 ; 118492
项目资助者: National Basic Research Programme of China ; National High Technology Research and Development Programme ; Finnish Academy
WOS记录号: WOS:000272161900012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61526
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Ctr Diabet, Beijing 100044, Peoples R China
2.Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
3.Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland

Recommended Citation:
Zhou, X. H.,Ji, L. N.,Luo, Y. Y.,et al. Performance of HbA(1c) for detecting newly diagnosed diabetes and pre-diabetes in Chinese communities living in Beijing[J]. DIABETIC MEDICINE,2009,26(12):1262-1268.
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