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学科主题: 基础医学
题名:
PDCD10 interacts with STK25 to accelerate cell apoptosis under oxidative stress
作者: Zhang, Heyu2,3,4; Ma, Xi5; Deng, Xuan2,3; Chen, Yiyu2,3; Mo, Xiaoning3; Zhang, Yingmei2,3; Zhao, Hongshan1,3; Ma, Dalong2,3
关键词: PDCD10 ; STK25 ; Apoptosis ; ERK ; Oxidative stress
刊名: FRONTIERS IN BIOSCIENCE-LANDMARK
发表日期: 2012-06-01
DOI: 10.2741/4053
卷: 17, 页:2295-2305
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: CEREBRAL CAVERNOUS MALFORMATIONS ; 20-LIKE KINASE-3 MST3 ; OXIDANT STRESS ; CARDIOVASCULAR EVENTS ; STE20-RELATED KINASE ; STE20-LIKE KINASE ; GENE-EXPRESSION ; CHEMICAL ANOXIA ; PROTEIN-KINASE ; CANCER-CELLS
英文摘要:

An apoptosis-related protein, cerebral cavernous malformation 3 (CCM3 or PDCD10), has recently been implicated in mutations associated with cerebral cavernous malformation. Herein, we show that PDCD10 interacts with serine/threonine kinase 25 (STK25), an oxidant stress response kinase related to sterile-20 (Ste20) that is activated by oxidative stress and induces apoptotic cell death. Functional investigations indicate that PDCD10 and STK25 protein are up-regulated by H2O2 stimulation, and that co-expression of the proteins accelerates cell apoptosis. The induction of small interfering PDCD10 (siPDCD10) or siSTK25 results in decreased endogenous PDCD10 and STK25 expression, which is accompanied by attenuated cell apoptosis. Interaction between PDCD10 and STK25 modulates ERK activity under oxidative stress. PDCD10 stabilizes STK25 protein through a proteasome-dependent pathway. Our findings suggest that PDCD10 might be a regulatory adaptor required for STK25 functions, which differ distinctly depending on the redox status of the cells that may be potentially related to tumor progression.

语种: 英语
所属项目编号: 30872940 ; 2009ZX09503-004
项目资助者: National Natural Science Foundation of China ; National Key New Drug Creation Program of China
WOS记录号: WOS:000311885100020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61529
Appears in Collections:基础医学院_医学遗传学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Med Genet, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100191, Peoples R China
3.Peking Univ, Human Dis Genom Ctr, Beijing 100191, Peoples R China
4.Peking Univ Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
5.China Agr Univ, State Key Lab Anim Nutr, Beijing 100193, Peoples R China

Recommended Citation:
Zhang, Heyu,Ma, Xi,Deng, Xuan,et al. PDCD10 interacts with STK25 to accelerate cell apoptosis under oxidative stress[J]. FRONTIERS IN BIOSCIENCE-LANDMARK,2012,17:2295-2305.
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