学科主题 | 临床医学 |
The association between the copy-number variations of ZMAT(4) and hematological malignancy | |
Wan, Jun2,3; Gao, Yan4; Zhao, Xiaosu5; Wu, Qi2; Fu, Xinrong3; Shao, Yong2; Yang, Hong6; Guan, Ming7; Yu, Bo2; Zhang, Wei1 | |
关键词 | Copy-number variations ZMAT4 Hematological malignancies |
刊名 | HEMATOLOGY
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2011 | |
DOI | 10.1179/102453311X12902908411751 |
卷 | 16期:1页:20-23 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Hematology |
研究领域[WOS] | Hematology |
关键词[WOS] | ACUTE LYMPHOBLASTIC-LEUKEMIA ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; HUMAN GENOME ; STRUCTURAL VARIATION ; GENE-EXPRESSION ; DELETION ; HETEROZYGOSITY ; SUSCEPTIBILITY ; POLYMORPHISM ; DISEASE |
英文摘要 | Copy-number variations (CNVs) have been found in association with various types of diseases, including hematological malignancies. A recent array-based study implicated the presence of CNVs of ZMAT4 in the genome of acute myelogenous leukemia. In our study, we collected 617 bone marrow samples from multitypes of hematological malignancies as well as healthy controls. We found significant association between the CNVs of ZMAT4 and these hematological malignancies, including acute lymphoblastic leukemia, acute myelogenous leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia, multiple myeloma, and myelodysplastic syndrome. We also examined the expression of ZMAT4 mRNA in the samples with 1 or 2 copies of DNA, and observed a weak yet positive correlation between the relative expression level and gene dosage. In conclusion, the CNVs of ZMAT4 have the potential to serve as a diagnostic indicator, alone or in combination with other markers, for hematological malignancies. |
语种 | 英语 |
WOS记录号 | WOS:000286637100004 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/61538 |
Collection | 北京大学第二临床医学院_血液科 |
作者单位 | 1.Capital Med Univ, Dept Anat, Beijing, Peoples R China 2.Huashan Hosp, Dept Clin Lab, Shanghai, Peoples R China 3.Jinan Univ, JNU HKUST Joint Lab, Guangzhou 510632, Guangdong, Peoples R China 4.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Peoples R China 5.Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China 6.Peking Univ, Dept Hematol, Peoples Hosp, Inst Hematol, Beijing 100871, Peoples R China 7.Peking Univ, Dept Clin Lab, Shenzhen Hosp, Beijing 100871, Peoples R China |
Recommended Citation GB/T 7714 | Wan, Jun,Gao, Yan,Zhao, Xiaosu,et al. The association between the copy-number variations of ZMAT(4) and hematological malignancy[J]. HEMATOLOGY,2011,16(1):20-23. |
APA | Wan, Jun.,Gao, Yan.,Zhao, Xiaosu.,Wu, Qi.,Fu, Xinrong.,...&Zhang, Wei.(2011).The association between the copy-number variations of ZMAT(4) and hematological malignancy.HEMATOLOGY,16(1),20-23. |
MLA | Wan, Jun,et al."The association between the copy-number variations of ZMAT(4) and hematological malignancy".HEMATOLOGY 16.1(2011):20-23. |
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