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The association between the copy-number variations of ZMAT(4) and hematological malignancy
Wan, Jun2,3; Gao, Yan4; Zhao, Xiaosu5; Wu, Qi2; Fu, Xinrong3; Shao, Yong2; Yang, Hong6; Guan, Ming7; Yu, Bo2; Zhang, Wei1
关键词Copy-number variations ZMAT4 Hematological malignancies
刊名HEMATOLOGY
2011
DOI10.1179/102453311X12902908411751
16期:1页:20-23
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]ACUTE LYMPHOBLASTIC-LEUKEMIA ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; HUMAN GENOME ; STRUCTURAL VARIATION ; GENE-EXPRESSION ; DELETION ; HETEROZYGOSITY ; SUSCEPTIBILITY ; POLYMORPHISM ; DISEASE
英文摘要

Copy-number variations (CNVs) have been found in association with various types of diseases, including hematological malignancies. A recent array-based study implicated the presence of CNVs of ZMAT4 in the genome of acute myelogenous leukemia. In our study, we collected 617 bone marrow samples from multitypes of hematological malignancies as well as healthy controls. We found significant association between the CNVs of ZMAT4 and these hematological malignancies, including acute lymphoblastic leukemia, acute myelogenous leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia, multiple myeloma, and myelodysplastic syndrome. We also examined the expression of ZMAT4 mRNA in the samples with 1 or 2 copies of DNA, and observed a weak yet positive correlation between the relative expression level and gene dosage. In conclusion, the CNVs of ZMAT4 have the potential to serve as a diagnostic indicator, alone or in combination with other markers, for hematological malignancies.

语种英语
WOS记录号WOS:000286637100004
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61538
专题北京大学第二临床医学院_血液科
北京大学口腔医学院_外科
北京大学临床肿瘤学院_护理部
作者单位1.Capital Med Univ, Dept Anat, Beijing, Peoples R China
2.Huashan Hosp, Dept Clin Lab, Shanghai, Peoples R China
3.Jinan Univ, JNU HKUST Joint Lab, Guangzhou 510632, Guangdong, Peoples R China
4.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Peoples R China
5.Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China
6.Peking Univ, Dept Hematol, Peoples Hosp, Inst Hematol, Beijing 100871, Peoples R China
7.Peking Univ, Dept Clin Lab, Shenzhen Hosp, Beijing 100871, Peoples R China
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GB/T 7714
Wan, Jun,Gao, Yan,Zhao, Xiaosu,et al. The association between the copy-number variations of ZMAT(4) and hematological malignancy[J]. HEMATOLOGY,2011,16(1):20-23.
APA Wan, Jun.,Gao, Yan.,Zhao, Xiaosu.,Wu, Qi.,Fu, Xinrong.,...&Zhang, Wei.(2011).The association between the copy-number variations of ZMAT(4) and hematological malignancy.HEMATOLOGY,16(1),20-23.
MLA Wan, Jun,et al."The association between the copy-number variations of ZMAT(4) and hematological malignancy".HEMATOLOGY 16.1(2011):20-23.
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