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学科主题: 临床医学
题名:
Association analysis of hepatitis virus B infection with haplotypes of the TBX21 gene promoter region in the Chinese population
作者: Cao, Bangwei; Yang, Hongli; Ding, Howard; Qi, Suxia; Gao, Lei; Cui, Hong; Dai, Yue; Xu, Changqing
关键词: genetic susceptibility ; haplotype ; hepatitis B virus (HBV) ; promoter ; TBX21 (T-box21) gene
刊名: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
发表日期: 2007
卷: 45, 期:3, 页:333-338
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: T-BET ; HEPATOCELLULAR-CARCINOMA ; MATHEMATICAL-MODEL ; VIRAL-HEPATITIS ; EXPRESSION ; POLYMORPHISMS ; CYTOKINES ; ASTHMA ; CELLS ; TH1
英文摘要:

Background: The T-box21 (TBX21) gene encodes the transcription factor T-bet (T-box expressed in T-cells), which influences naive T-lymphocyte development and has been implicated in the pathogenesis of many diseases.

Methods: We selected 208 hepatitis B patients and 213 healthy volunteers to examine whether polymorphisms or haplotypes of the TBX21 gene promoter were associated with hepatitis B virus (HBV) infection in the Chinese population. Two polymorphisms at -1499 and -1514 located in the TBX21 promoter region were identified by the PCR-restriction fragment length polymorphism (PCR-RFLP) method.

Results: Single nucleoticle polymorphism (SNP) at -1499 was significantly different between HBV patients and healthy controls [p=0.003; odds ratio (OR) 3.65, 95% confidence interval (CI) 1.58-8.45]. Similarly, our results showed a significantly higher level of haplotype D (--/AC) in HBV patients compared to control subjects (p=0.005; OR 4.82, 95% Cl 1.59-14.61).

Conclusions: Based on our findings, it seems that genetic variations of allele -1499 and haplotype D (--/AC) within the TBX21 promoter region contribute to susceptibility to HBV infection in the Chinese population.

语种: 英语
WOS记录号: WOS:000245357200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61540
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Univ New S Wales, Sydney, NSW, Australia
2.Qianfoshan Univ, Dept Gastroenterol, Jinan 250014, Shandong Prov, Peoples R China
3.Peking Univ, Dept Antiinfect, Hosp 1, Beijing 100871, Peoples R China
4.Peking Univ, Inst Clin Pharmacol, Hosp 1, Beijing 100871, Peoples R China
5.Peking Univ, Dept Blood Transfus, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Cao, Bangwei,Yang, Hongli,Ding, Howard,et al. Association analysis of hepatitis virus B infection with haplotypes of the TBX21 gene promoter region in the Chinese population[J]. CLINICAL CHEMISTRY AND LABORATORY MEDICINE,2007,45(3):333-338.
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