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学科主题临床医学
Dysfunction of myocardial sarcoplasmic reticulum. in rats with myocardial calcification
Bin, G; Fen, QY; Hua, LX; Hong, ZB; Zheng, PY; Shu, TC
关键词myocardial calcification sarcoplasmic reticulum dysfunction NO/NOS pathway
刊名LIFE SCIENCES
2005-07-15
DOI10.1016/j.lfs.2004.12.037
77期:9页:966-979
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]VITAMIN-D-3 PLUS NICOTINE ; NITRIC-OXIDE SYNTHASE ; VASCULAR CALCIFICATION ; HEART-FAILURE ; CONTRACTILITY ; MECHANISM ; MUSCLE ; CELLS ; AGE
英文摘要

We investigated the relationship between cardiac dysfunction and Ca2+ transport in the myocardial sarcoplasmic reticulum (SR) during the pathogenesis of cardiovascular calcification in rats. The possible mechanism of SR dysfunction was explored by detecting the alteration of the nitric oxide/nitric oxide synthase (NO/NOS) pathway in the SR. Using the vitamin D plus nicotine (VDN treatment for 2 week and 6 week) experimental model of cardiac calcification, cardiac function and sarcoplasmic reticulum function were measured. Inhibition of cardiac functions in vivo (peak rate of contraction and peak rate of relaxation, P < 0.05 or P < 0.01) were observed in all calcification groups, simultaneously, Ca2+ release and uptake in the SR as well as the Ca2+ release channel and Ca2+ PUMP activity were inhibited. Myocardial Ca2+ concentration and cardiac and SR dysfunction were inversely related (P < 0.05). The specific NO/NOS pathway (NO production, NOS activity and nNOS expression in the SR) was upregulated in the SR and associated with calcification (both 2- and 6 week VDN groups). These results indicate that cardiac dysfunction associated with myocardial calcification might be mediated by SR dysfunction, which may result from an impaired SR-specific NO/NOS pathway. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000230238300002
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61542
专题北京大学第一临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100034, Peoples R China
3.Hlth Sci Ctr, Minist Mol Cardiol, Ref Lab Educ, Beijing 100034, Peoples R China
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GB/T 7714
Bin, G,Fen, QY,Hua, LX,et al. Dysfunction of myocardial sarcoplasmic reticulum. in rats with myocardial calcification[J]. LIFE SCIENCES,2005,77(9):966-979.
APA Bin, G,Fen, QY,Hua, LX,Hong, ZB,Zheng, PY,&Shu, TC.(2005).Dysfunction of myocardial sarcoplasmic reticulum. in rats with myocardial calcification.LIFE SCIENCES,77(9),966-979.
MLA Bin, G,et al."Dysfunction of myocardial sarcoplasmic reticulum. in rats with myocardial calcification".LIFE SCIENCES 77.9(2005):966-979.
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