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学科主题: 临床医学
题名:
Dysfunction of myocardial sarcoplasmic reticulum. in rats with myocardial calcification
作者: Bin, G; Fen, QY; Hua, LX; Hong, ZB; Zheng, PY; Shu, TC
关键词: myocardial calcification ; sarcoplasmic reticulum dysfunction ; NO/NOS pathway
刊名: LIFE SCIENCES
发表日期: 2005-07-15
DOI: 10.1016/j.lfs.2004.12.037
卷: 77, 期:9, 页:966-979
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: VITAMIN-D-3 PLUS NICOTINE ; NITRIC-OXIDE SYNTHASE ; VASCULAR CALCIFICATION ; HEART-FAILURE ; CONTRACTILITY ; MECHANISM ; MUSCLE ; CELLS ; AGE
英文摘要:

We investigated the relationship between cardiac dysfunction and Ca2+ transport in the myocardial sarcoplasmic reticulum (SR) during the pathogenesis of cardiovascular calcification in rats. The possible mechanism of SR dysfunction was explored by detecting the alteration of the nitric oxide/nitric oxide synthase (NO/NOS) pathway in the SR. Using the vitamin D plus nicotine (VDN treatment for 2 week and 6 week) experimental model of cardiac calcification, cardiac function and sarcoplasmic reticulum function were measured. Inhibition of cardiac functions in vivo (peak rate of contraction and peak rate of relaxation, P < 0.05 or P < 0.01) were observed in all calcification groups, simultaneously, Ca2+ release and uptake in the SR as well as the Ca2+ release channel and Ca2+ PUMP activity were inhibited. Myocardial Ca2+ concentration and cardiac and SR dysfunction were inversely related (P < 0.05). The specific NO/NOS pathway (NO production, NOS activity and nNOS expression in the SR) was upregulated in the SR and associated with calcification (both 2- and 6 week VDN groups). These results indicate that cardiac dysfunction associated with myocardial calcification might be mediated by SR dysfunction, which may result from an impaired SR-specific NO/NOS pathway. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000230238300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61542
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100034, Peoples R China
3.Hlth Sci Ctr, Minist Mol Cardiol, Ref Lab Educ, Beijing 100034, Peoples R China

Recommended Citation:
Bin, G,Fen, QY,Hua, LX,et al. Dysfunction of myocardial sarcoplasmic reticulum. in rats with myocardial calcification[J]. LIFE SCIENCES,2005,77(9):966-979.
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