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学科主题: 精神卫生
题名:
Do SNPs of DRD4 gene predict adult persistence of ADHD in a Chinese sample?
作者: Li, Yueling1,2; Baker-Ericzen, Mary3; Ji, Ning1,2; Chang, Weili1,2; Guan, Lili1,2; Qian, Qiujin1,2; Zhang, Yujuan4; Faraone, Stephen V.5,6; Wang, Yufeng1,2
关键词: Dopamine D4 receptor (DRD4) ; Attention-deficit/hyperactivity disorder (ADHD) ; Longitudinal ; Adult ADHD ; Han Chinese
刊名: PSYCHIATRY RESEARCH
发表日期: 2013-01-30
DOI: 10.1016/j.psychres.2012.08.016
卷: 205, 期:1-2, 页:143-150
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: DEFICIT-HYPERACTIVITY DISORDER ; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; DOPAMINE-D4 RECEPTOR GENE ; TANDEM DUPLICATION POLYMORPHISM ; 4 EUROPEAN POPULATIONS ; PROMOTER REGION ; CANDIDATE GENE ; ASSOCIATION ; METAANALYSIS ; PREVALENCE
英文摘要:

The dopamine D4 receptor (DRD4) gene has been frequently studied in relation to attention deficit hyperactivity disorder (ADHD) but little is known about the contribution of single nucleotide polymorphisms (SNPs) of the DRD4 gene to the development and persistence of ADHD. In the present study, we examined the association between two SNPs in DRD4 (rs1800955, rs916455) and adult ADHD persistence in a Chinese sample. Subjects (n=193) were diagnosed with ADHD in childhood and reassessed in young adulthood at an affiliated clinic of Peking University Sixth Hospital. Kaplan-Meier survival analyses and Cox proportional hazard models were used to test the association between ADHD remission and alleles of the two SNPs. DRD4 rs916455 C allele carriers were more likely to have persistent ADHD symptoms in adulthood. No significant association was found between rs1800955 allele and the course of ADHD. These newly detected associations between DRD4 polymorphisms and ADHD prognosis in adulthood may help to predict the persistence of childhood ADHD into adulthood. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 200802073 ; 2007BAI17B03
项目资助者: Commonweal Sciences Foundation ; Ministry of Health, China ; National Foundation, Ministry of Science and Technology, China
WOS记录号: WOS:000315252500023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61545
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
3.Rady Childrens Hosp, Child & Adolescent Serv Res Ctr, San Diego, CA USA
4.Xinjiang Med Univ, Affiliated Hosp 2, Xinjiang, Henan, Peoples R China
5.SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA
6.SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA

Recommended Citation:
Li, Yueling,Baker-Ericzen, Mary,Ji, Ning,et al. Do SNPs of DRD4 gene predict adult persistence of ADHD in a Chinese sample?[J]. PSYCHIATRY RESEARCH,2013,205(1-2):143-150.
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