|Graph Theoretical Analysis of BOLD Functional Connectivity during Human Sleep without EEG Monitoring|
|Lv, Jun1; Liu, Dongdong2; Ma, Jing3; Wang, Xiaoying1,4; Zhang, Jue1,5|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||SMALL-WORLD NETWORKS ; EYE-MOVEMENT SLEEP ; COMPLEX BRAIN NETWORKS ; CEREBRAL-CORTEX ; ORGANIZATION ; CONSCIOUSNESS ; STIMULATION ; INSIGHTS ; SYSTEMS ; PET|
Functional brain networks of human have been revealed to have small-world properties by both analyzing electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) time series.
Methods & Results
In our study, by using graph theoretical analysis, we attempted to investigate the changes of paralimbic-limbic cortex between wake and sleep states. Ten healthy young people were recruited to our experiment. Data from 2 subjects were excluded for the reason that they had not fallen asleep during the experiment. For each subject, blood oxygen level dependency (BOLD) images were acquired to analyze brain network, and peripheral pulse signals were obtained continuously to identify if the subject was in sleep periods. Results of fMRI showed that brain networks exhibited stronger small-world characteristics during sleep state as compared to wake state, which was in consistent with previous studies using EEG synchronization. Moreover, we observed that compared with wake state, paralimbic-limbic cortex had less connectivity with neocortical system and centrencephalic structure in sleep.
In conclusion, this is the first study, to our knowledge, has observed that small-world properties of brain functional networks altered when human sleeps without EEG synchronization. Moreover, we speculate that paralimbic-limbic cortex organization owns an efficient defense mechanism responsible for suppressing the external environment interference when humans sleep, which is consistent with the hypothesis that the paralimbic-limbic cortex may be functionally disconnected from brain regions which directly mediate their interactions with the external environment. Our findings also provide a reasonable explanation why stable sleep exhibits homeostasis which is far less susceptible to outside world.
|作者单位||1.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China|
2.Capital Med Univ, Sch Biomed Engn, Beijing, Peoples R China
3.Peking Univ, Dept Pulm Med, Hosp 1, Beijing 100871, Peoples R China
4.Peking Univ, Dept Radiol, Hosp 1, Beijing 100871, Peoples R China
5.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
|Lv, Jun,Liu, Dongdong,Ma, Jing,et al. Graph Theoretical Analysis of BOLD Functional Connectivity during Human Sleep without EEG Monitoring[J]. PLOS ONE,2015,10(9).|
|APA||Lv, Jun,Liu, Dongdong,Ma, Jing,Wang, Xiaoying,&Zhang, Jue.(2015).Graph Theoretical Analysis of BOLD Functional Connectivity during Human Sleep without EEG Monitoring.PLOS ONE,10(9).|
|MLA||Lv, Jun,et al."Graph Theoretical Analysis of BOLD Functional Connectivity during Human Sleep without EEG Monitoring".PLOS ONE 10.9(2015).|