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学科主题: 药学
题名:
Microbial transformation of asiatic acid by Alternaria longipes
作者: He, Wen-Ni1,2; Dai, Jun-Gui3,4; Ye, Min1; Wu, Li-Jun2; Guo, De-An1
关键词: asiatic acid ; Alternaria longipes ; microbial transformation ; triterpene
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
发表日期: 2010
DOI: 10.1080/10286020.2010.501505
卷: 12, 期:9, 页:760-764
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: CELLS
英文摘要:

Asiatic acid is a major pentacyclic triterpene isolated from Centella asiatica. It shows a variety of bioactivities. In order to obtain its derivatives, potentially useful for detailed pharmacological studies, the substrate was subjected to incubations with selected micro-organisms. In this work, asiatic acid was converted into three new compounds: 2,3,23,30-tetrahydroxyurs-12-ene-28-oic acid (1), 2,3,22,23-tetrahydroxyurs-12-ene-28-oic acid (2), and 2,3,22,23,30-pentahydroxyurs-12-ene-28-oic acid (3) by the fungus Alternaria longipes AS 3.2875. The structures of the three metabolites were determined by 1D and 2D NMR spectral data.

语种: 英语
所属项目编号: 7102103 ; 2009B02
项目资助者: Beijing Natural Science Foundation ; Beijing NOVA Program
WOS记录号: WOS:000281762900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61547
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
4.Peking Union Med Coll, Beijing 100050, Peoples R China

Recommended Citation:
He, Wen-Ni,Dai, Jun-Gui,Ye, Min,et al. Microbial transformation of asiatic acid by Alternaria longipes[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2010,12(9):760-764.
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