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Microbial transformation of asiatic acid by Alternaria longipes
He, Wen-Ni1,2; Dai, Jun-Gui3,4; Ye, Min1; Wu, Li-Jun2; Guo, De-An1
关键词asiatic acid Alternaria longipes microbial transformation triterpene
刊名JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
2010
DOI10.1080/10286020.2010.501505
12期:9页:760-764
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]CELLS
英文摘要

Asiatic acid is a major pentacyclic triterpene isolated from Centella asiatica. It shows a variety of bioactivities. In order to obtain its derivatives, potentially useful for detailed pharmacological studies, the substrate was subjected to incubations with selected micro-organisms. In this work, asiatic acid was converted into three new compounds: 2,3,23,30-tetrahydroxyurs-12-ene-28-oic acid (1), 2,3,22,23-tetrahydroxyurs-12-ene-28-oic acid (2), and 2,3,22,23,30-pentahydroxyurs-12-ene-28-oic acid (3) by the fungus Alternaria longipes AS 3.2875. The structures of the three metabolites were determined by 1D and 2D NMR spectral data.

语种英语
WOS记录号WOS:000281762900005
项目编号7102103 ; 2009B02
资助机构Beijing Natural Science Foundation ; Beijing NOVA Program
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61547
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
4.Peking Union Med Coll, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
He, Wen-Ni,Dai, Jun-Gui,Ye, Min,et al. Microbial transformation of asiatic acid by Alternaria longipes[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2010,12(9):760-764.
APA He, Wen-Ni,Dai, Jun-Gui,Ye, Min,Wu, Li-Jun,&Guo, De-An.(2010).Microbial transformation of asiatic acid by Alternaria longipes.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,12(9),760-764.
MLA He, Wen-Ni,et al."Microbial transformation of asiatic acid by Alternaria longipes".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 12.9(2010):760-764.
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