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学科主题: 临床医学
题名:
Roles of Human Urotensin II in Volume Resistance Hypertension in Peritoneal Dialysis Patients
作者: Bai, Qiong; Zhang, Jing; Zhang, Ai-Hua; Cheng, Li-Tao; He, Lian; Fan, Min-Hua; Luo, Ya-Jun; Wang, Tao
关键词: human urotensin II ; continuous ambulatory peritoneal dialysis ; volume resistance ; hypertension
刊名: RENAL FAILURE
发表日期: 2012
DOI: 10.3109/0886022X.2012.672267
卷: 34, 期:6, 页:713-717
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
英文摘要:

Human urotensin II (hUII) is a newly discovered substance that can dilate small blood vessels to decrease the blood pressure (BP). Our previous studies showed that some volume-overloaded patients on peritoneal dialysis can maintain normal BP (congestive heart failure excluded), suggesting that these patients have volume resistance capacity. This study is to investigate whether hUII plays an important role in this subgroup of patients on peritoneal dialysis. In this study, 105 patients on continuous ambulatory peritoneal dialysis were enrolled. Volume load was evaluated by the overhydration (OH) value obtained by bioimpedance analysis. OH < 2.0 kg was defined as normal volume (NV), and OH >= 2.0 kg as high volume (HV). Systolic blood pressure (SBP) <130 mmHg was defined as normotension (NT) and >= 130 mmHg as hypertension (HT). The patients were thus divided into four subgroups: (1) normotension with normal volume (NT-NV), (2) normotension with high volume (NT-HV), (3) normal volume with hypertension (HT-NV), and (4) high volume with hypertension (HT-HV). hUII was measured using radioimmunoassay method. hUII was significantly higher in normal SBP group than that in high SBP group (p < 0.05). hUII was higher in the NT-HV group compared with that in the HT-HV group (p < 0.05). Our study suggests that hUII may be involved in the pathogenesis of the volume resistance HT in peritoneal dialysis patients.

语种: 英语
所属项目编号: 30800522 ; 200800011034 ; 81170706
项目资助者: National Natural Science Foundation ; Specialized Research Fund for the Doctoral Program of Higher Education ; Peking University Third Hospital ; National Natural Science Foundation of China
WOS记录号: WOS:000305013400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61551
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: Peking Univ, Dept Nephrol, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Bai, Qiong,Zhang, Jing,Zhang, Ai-Hua,et al. Roles of Human Urotensin II in Volume Resistance Hypertension in Peritoneal Dialysis Patients[J]. RENAL FAILURE,2012,34(6):713-717.
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