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Roles of Human Urotensin II in Volume Resistance Hypertension in Peritoneal Dialysis Patients
Bai, Qiong; Zhang, Jing; Zhang, Ai-Hua; Cheng, Li-Tao; He, Lian; Fan, Min-Hua; Luo, Ya-Jun; Wang, Tao
关键词human urotensin II continuous ambulatory peritoneal dialysis volume resistance hypertension
刊名RENAL FAILURE
2012
DOI10.3109/0886022X.2012.672267
34期:6页:713-717
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
英文摘要

Human urotensin II (hUII) is a newly discovered substance that can dilate small blood vessels to decrease the blood pressure (BP). Our previous studies showed that some volume-overloaded patients on peritoneal dialysis can maintain normal BP (congestive heart failure excluded), suggesting that these patients have volume resistance capacity. This study is to investigate whether hUII plays an important role in this subgroup of patients on peritoneal dialysis. In this study, 105 patients on continuous ambulatory peritoneal dialysis were enrolled. Volume load was evaluated by the overhydration (OH) value obtained by bioimpedance analysis. OH < 2.0 kg was defined as normal volume (NV), and OH >= 2.0 kg as high volume (HV). Systolic blood pressure (SBP) <130 mmHg was defined as normotension (NT) and >= 130 mmHg as hypertension (HT). The patients were thus divided into four subgroups: (1) normotension with normal volume (NT-NV), (2) normotension with high volume (NT-HV), (3) normal volume with hypertension (HT-NV), and (4) high volume with hypertension (HT-HV). hUII was measured using radioimmunoassay method. hUII was significantly higher in normal SBP group than that in high SBP group (p < 0.05). hUII was higher in the NT-HV group compared with that in the HT-HV group (p < 0.05). Our study suggests that hUII may be involved in the pathogenesis of the volume resistance HT in peritoneal dialysis patients.

语种英语
WOS记录号WOS:000305013400008
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61551
专题北京大学第三临床医学院_肾内科
北京大学公共卫生学院_公共卫生学院
作者单位Peking Univ, Dept Nephrol, Hosp 3, Beijing 100871, Peoples R China
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GB/T 7714
Bai, Qiong,Zhang, Jing,Zhang, Ai-Hua,et al. Roles of Human Urotensin II in Volume Resistance Hypertension in Peritoneal Dialysis Patients[J]. RENAL FAILURE,2012,34(6):713-717.
APA Bai, Qiong.,Zhang, Jing.,Zhang, Ai-Hua.,Cheng, Li-Tao.,He, Lian.,...&Wang, Tao.(2012).Roles of Human Urotensin II in Volume Resistance Hypertension in Peritoneal Dialysis Patients.RENAL FAILURE,34(6),713-717.
MLA Bai, Qiong,et al."Roles of Human Urotensin II in Volume Resistance Hypertension in Peritoneal Dialysis Patients".RENAL FAILURE 34.6(2012):713-717.
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