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Contribution of 5-HT2A receptor gene-1438A > G polymorphism to outcome of attention-deficit/hyperactivity disorder in adolescents
Li, J; Kang, CY; Wang, YF; Zhou, RL; Wang, B; Guan, LL; Yang, L; Faraone, SV
关键词serotonin HTR2A HTR2C attention-deficit/hyperactivity disorder (ADHD) outcome adolescent
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2006-07-05
DOI10.1002/ajmg.b.30320
141B期:5页:473-476
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]DEFICIT HYPERACTIVITY DISORDER ; AGE-DEPENDENT DECLINE ; GENE ; ADHD ; SYMPTOMS ; CHILDREN ; SUSCEPTIBILITY ; ASSOCIATION ; PERSISTENCE ; CHILDHOOD
英文摘要

Attention-deficit/hyperactivity disorder (ADHD) typically emerges before 7 years of age and may persist into adolescence or adulthood. The adolescent outcome can be classified into four types, including non-remission, syndromatic remission, symptomatic remission, and functional remission. Genetic factors are believed to contribute to symptom stability and change across development, so adolescent outcome may be a sub-phenotype for molecular genetic studies of ADHD. Serotonin system genes are prime candidates for this sub-phenotype, since the development of this neurotransmitter system parallels the course of ADHD. The current study examined the association between adolescent outcome in ADHD and serotonin system genes, including the -1438A > G polymorphism of the serotonin 2A receptor gene (HTR2A) and the -759C > T polymorphism of the serotonin 2C receptor gene (HTR2C). The -1438A > G polymorphism was found to be related to remission in ADHD, especially functional remission (P = 0.029). Due to potential phenotypic and etiologic heterogeneity in ADHD, the results of this study must be replicated in additional samples before they can be generalized to other populations. (c) 2006 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000238622300007
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61564
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Peking Univ Hosp 6, Beijing 100083, Peoples R China
2.SUNY Upstate Med Univ, Med Genet Res Program, Syracuse, NY USA
3.SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY USA
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GB/T 7714
Li, J,Kang, CY,Wang, YF,et al. Contribution of 5-HT2A receptor gene-1438A > G polymorphism to outcome of attention-deficit/hyperactivity disorder in adolescents[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2006,141B(5):473-476.
APA Li, J.,Kang, CY.,Wang, YF.,Zhou, RL.,Wang, B.,...&Faraone, SV.(2006).Contribution of 5-HT2A receptor gene-1438A > G polymorphism to outcome of attention-deficit/hyperactivity disorder in adolescents.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,141B(5),473-476.
MLA Li, J,et al."Contribution of 5-HT2A receptor gene-1438A > G polymorphism to outcome of attention-deficit/hyperactivity disorder in adolescents".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 141B.5(2006):473-476.
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