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学科主题: 精神卫生
题名:
Contribution of 5-HT2A receptor gene-1438A > G polymorphism to outcome of attention-deficit/hyperactivity disorder in adolescents
作者: Li, J; Kang, CY; Wang, YF; Zhou, RL; Wang, B; Guan, LL; Yang, L; Faraone, SV
关键词: serotonin ; HTR2A ; HTR2C ; attention-deficit/hyperactivity disorder (ADHD) ; outcome ; adolescent
刊名: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
发表日期: 2006-07-05
DOI: 10.1002/ajmg.b.30320
卷: 141B, 期:5, 页:473-476
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Psychiatry
研究领域[WOS]: Genetics & Heredity ; Psychiatry
关键词[WOS]: DEFICIT HYPERACTIVITY DISORDER ; AGE-DEPENDENT DECLINE ; GENE ; ADHD ; SYMPTOMS ; CHILDREN ; SUSCEPTIBILITY ; ASSOCIATION ; PERSISTENCE ; CHILDHOOD
英文摘要:

Attention-deficit/hyperactivity disorder (ADHD) typically emerges before 7 years of age and may persist into adolescence or adulthood. The adolescent outcome can be classified into four types, including non-remission, syndromatic remission, symptomatic remission, and functional remission. Genetic factors are believed to contribute to symptom stability and change across development, so adolescent outcome may be a sub-phenotype for molecular genetic studies of ADHD. Serotonin system genes are prime candidates for this sub-phenotype, since the development of this neurotransmitter system parallels the course of ADHD. The current study examined the association between adolescent outcome in ADHD and serotonin system genes, including the -1438A > G polymorphism of the serotonin 2A receptor gene (HTR2A) and the -759C > T polymorphism of the serotonin 2C receptor gene (HTR2C). The -1438A > G polymorphism was found to be related to remission in ADHD, especially functional remission (P = 0.029). Due to potential phenotypic and etiologic heterogeneity in ADHD, the results of this study must be replicated in additional samples before they can be generalized to other populations. (c) 2006 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000238622300007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61564
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Peking Univ Hosp 6, Beijing 100083, Peoples R China
2.SUNY Upstate Med Univ, Med Genet Res Program, Syracuse, NY USA
3.SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY USA

Recommended Citation:
Li, J,Kang, CY,Wang, YF,et al. Contribution of 5-HT2A receptor gene-1438A > G polymorphism to outcome of attention-deficit/hyperactivity disorder in adolescents[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2006,141B(5):473-476.
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