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学科主题: 临床医学
题名:
Brain dopaminergic system changes in drug addiction: a review of positron emission tomography findings
作者: Hou, Haifeng1,2,3,4; Wang, Chunyan5; Jia, Shaowei6; Hu, Shu6; Tian, Mei1,2,3,4
关键词: dopamine ; dopaminergic system ; drug addiction ; positron emission tomography
刊名: NEUROSCIENCE BULLETIN
发表日期: 2014-10-01
DOI: 10.1007/s12264-014-1469-5
卷: 30, 期:5, 页:765-776
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: MONOAMINE TRANSPORTER BINDING ; C-11 BETA-CIT ; RECEPTOR AVAILABILITY ; METHAMPHETAMINE ABUSERS ; BEHAVIORAL ADDICTIONS ; PARKINSONS-DISEASE ; COCAINE ABUSERS ; BABOON BRAIN ; DSM-V ; ABSTINENT METHAMPHETAMINE
英文摘要:

Dopamine (DA) is considered crucial for the rewarding effects of drugs of abuse, but its role in addiction remains unclear. Positron emission tomography (PET) is the first technology used for in vivo measurement of components of the dopaminergic system in the human brain. In this article, we review the major findings from PET imaging studies on the involvement of DA in drug addiction, including presynaptic DA synthesis, vesicular monoamine transporter 2, the DA transporter, and postsynaptic DA receptors. These results have corroborated the role of DA in addiction and increased the understanding of its underlying mechanisms.

语种: 英语
所属项目编号: 2013CB329506 ; 81301243 ; 81271601 ; 20120101120031 ; 20130101110015 ; 2014KYA095 ; WKJ2013-2-016 ; Y560252013 ; LR13H180001
项目资助者: National Basic Research Development Program of China ; National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China ; Health Bureau of Zhejiang Province ; Scientific Research Foundation for Doctors of Second Affiliated Hospital of Zhejiang University School of Medicine ; Natural Science Foundation of Zhejiang Province, China
WOS记录号: WOS:000342554200005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61566
Appears in Collections:北京大学深圳医院_核医学科_期刊论文

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作者单位: 1.Beijing 307 Hosp, Beijing 100071, Peoples R China
2.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Nucl Med, Hangzhou 310009, Zhejiang, Peoples R China
3.Zhejiang Univ, Med PET Ctr, Hangzhou 310009, Zhejiang, Peoples R China
4.Zhejiang Univ, Inst Nucl Med & Mol Imaging, Hangzhou 310009, Zhejiang, Peoples R China
5.Key Lab Med Mol Imaging Zhejiang Prov, Hangzhou 310009, Zhejiang, Peoples R China
6.Peking Univ, Shenzhen Hosp, Dept Nucl Med, Shenzhen 518036, Peoples R China

Recommended Citation:
Hou, Haifeng,Wang, Chunyan,Jia, Shaowei,et al. Brain dopaminergic system changes in drug addiction: a review of positron emission tomography findings[J]. NEUROSCIENCE BULLETIN,2014,30(5):765-776.
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