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Brain dopaminergic system changes in drug addiction: a review of positron emission tomography findings
Hou, Haifeng1,2,3,4; Wang, Chunyan5; Jia, Shaowei6; Hu, Shu6; Tian, Mei1,2,3,4
关键词dopamine dopaminergic system drug addiction positron emission tomography
刊名NEUROSCIENCE BULLETIN
2014-10-01
DOI10.1007/s12264-014-1469-5
30期:5页:765-776
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MONOAMINE TRANSPORTER BINDING ; C-11 BETA-CIT ; RECEPTOR AVAILABILITY ; METHAMPHETAMINE ABUSERS ; BEHAVIORAL ADDICTIONS ; PARKINSONS-DISEASE ; COCAINE ABUSERS ; BABOON BRAIN ; DSM-V ; ABSTINENT METHAMPHETAMINE
英文摘要

Dopamine (DA) is considered crucial for the rewarding effects of drugs of abuse, but its role in addiction remains unclear. Positron emission tomography (PET) is the first technology used for in vivo measurement of components of the dopaminergic system in the human brain. In this article, we review the major findings from PET imaging studies on the involvement of DA in drug addiction, including presynaptic DA synthesis, vesicular monoamine transporter 2, the DA transporter, and postsynaptic DA receptors. These results have corroborated the role of DA in addiction and increased the understanding of its underlying mechanisms.

语种英语
WOS记录号WOS:000342554200005
项目编号2013CB329506 ; 81301243 ; 81271601 ; 20120101120031 ; 20130101110015 ; 2014KYA095 ; WKJ2013-2-016 ; Y560252013 ; LR13H180001
资助机构National Basic Research Development Program of China ; National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China ; Health Bureau of Zhejiang Province ; Scientific Research Foundation for Doctors of Second Affiliated Hospital of Zhejiang University School of Medicine ; Natural Science Foundation of Zhejiang Province, China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61566
专题北京大学深圳医院_核医学科
作者单位1.Beijing 307 Hosp, Beijing 100071, Peoples R China
2.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Nucl Med, Hangzhou 310009, Zhejiang, Peoples R China
3.Zhejiang Univ, Med PET Ctr, Hangzhou 310009, Zhejiang, Peoples R China
4.Zhejiang Univ, Inst Nucl Med & Mol Imaging, Hangzhou 310009, Zhejiang, Peoples R China
5.Key Lab Med Mol Imaging Zhejiang Prov, Hangzhou 310009, Zhejiang, Peoples R China
6.Peking Univ, Shenzhen Hosp, Dept Nucl Med, Shenzhen 518036, Peoples R China
推荐引用方式
GB/T 7714
Hou, Haifeng,Wang, Chunyan,Jia, Shaowei,et al. Brain dopaminergic system changes in drug addiction: a review of positron emission tomography findings[J]. NEUROSCIENCE BULLETIN,2014,30(5):765-776.
APA Hou, Haifeng,Wang, Chunyan,Jia, Shaowei,Hu, Shu,&Tian, Mei.(2014).Brain dopaminergic system changes in drug addiction: a review of positron emission tomography findings.NEUROSCIENCE BULLETIN,30(5),765-776.
MLA Hou, Haifeng,et al."Brain dopaminergic system changes in drug addiction: a review of positron emission tomography findings".NEUROSCIENCE BULLETIN 30.5(2014):765-776.
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