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Disruption of primary and secondary esophageal peristalsis by afferent stimulation
Bardan, E; Xie, PY; Aslam, M; Kern, M; Shaker, R
关键词peristaltic inhibition esophageal afferents pharyngeal afferents esophageal dysmotility
刊名AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
2000-08-01
279期:2页:G255-G261
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Physiology
研究领域[WOS]Gastroenterology & Hepatology ; Physiology
关键词[WOS]PHARYNGEAL WATER STIMULATION ; DRY SWALLOWS ; INHIBITION ; PRESSURE ; HUMANS ; WET
英文摘要

Recent studies have shown that afferent signals originating from the pharynx inhibit progression of primary esophageal peristalsis. Our aim was to further elucidate the effect of esophageal and pharyngeal afferent stimulation on primary and secondary esophageal peristalsis. We studied the effect of esophageal air distension and pharyngeal water stimulation on progression of primary and secondary peristalsis in nine healthy volunteers aged 27 +/- 2 yr (4 men, 5 women). At a threshold volume, rapid injection of water into the pharynx, directed posteriorly, resulted in complete halt of the progressing secondary and primary esophageal peristalses in both the proximal and distal esophagus. The threshold volume of injected water for inducing inhibition was similar for secondary (0.6 +/- 0.2 ml) and primary (0.5 +/- 0.1 ml) esophageal peristalsis. Progression of primary peristalsis induced by a dry swallow and secondary peristalsis induced by intraesophageal air distension were completely inhibited by intraesophageal injection of 15 +/- 2 ml of air in 70% and 75% of the trials, respectively. We conclude that afferent signals induced by esophageal air distension and pharyngeal water stimulation inhibit propagation of both primary and secondary esophageal peristalsis, suggesting a shared neural control mechanism for these types of peristalsis.

语种英语
WOS记录号WOS:000088408200003
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61569
专题北京大学第一临床医学院
作者单位1.Zablocki Dept Vet Affairs Med Ctr, Milwaukee, WI 53226 USA
2.Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel
3.Beijing Med Univ, Teaching Hosp 1, Beijing, Peoples R China
4.Med Coll Wisconsin, Dysphagia Inst, Dept Radiol, Milwaukee, WI 53226 USA
5.Med Coll Wisconsin, Dysphagia Inst, Dept Otolaryngol, Milwaukee, WI 53226 USA
6.Med Coll Wisconsin, Dysphagia Inst, Dept Med, Div Gastroenterol & Hepatol, Milwaukee, WI 53226 USA
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Bardan, E,Xie, PY,Aslam, M,et al. Disruption of primary and secondary esophageal peristalsis by afferent stimulation[J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY,2000,279(2):G255-G261.
APA Bardan, E,Xie, PY,Aslam, M,Kern, M,&Shaker, R.(2000).Disruption of primary and secondary esophageal peristalsis by afferent stimulation.AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY,279(2),G255-G261.
MLA Bardan, E,et al."Disruption of primary and secondary esophageal peristalsis by afferent stimulation".AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 279.2(2000):G255-G261.
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