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Discovery of Iminosugar Derivatives with Strong IFN-gamma Inducing Activity
Zhang, Lei1,2; Sun, Fang1,2; Wang, Qilong3; Zhou, Jing3; Zhang, Li-He1,2; Zhang, Xiao-Lian3; Ye, Xin-Shan1,2
关键词antibacterial agents iminosugars interferon-gamma library screening synthesis
刊名CHEMMEDCHEM
2009-05-01
DOI10.1002/cmdc.200900027
4期:5页:756-760
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]INTERFERON-GAMMA ; MYCOBACTERIAL INFECTION ; GLYCOSIDASE INHIBITORS ; TARGETED DISRUPTION ; RECEPTOR ; MICE ; AGENTS ; SUSCEPTIBILITY ; DEFECTS ; GROWTH
英文摘要

Through effective construction of a compound library and in situ cell-based screening, several iminosugar derivatives were discovered that show a strong ability to enhance IFN-gamma secretion. In particular, compounds A45 and B8, which exhibit remarkable activity in stimulating IFN-gamma secretion, show good antibacterial activity in vivo and have the potential to be lead compounds for further studies in the search for drugs for the treatment of cancer′ and microbial infections.

语种英语
WOS记录号WOS:000266385000008
资助机构Ministry of Science and Technology of China
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61572
专题北京大学药学院
北京大学药学院_药物化学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Wuhan Univ, Coll Med, Dept Immunol, State Key Lab Virol Hubei Prov Key Lab Allergy &, Wuhan 430071, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Lei,Sun, Fang,Wang, Qilong,et al. Discovery of Iminosugar Derivatives with Strong IFN-gamma Inducing Activity[J]. CHEMMEDCHEM,2009,4(5):756-760.
APA Zhang, Lei.,Sun, Fang.,Wang, Qilong.,Zhou, Jing.,Zhang, Li-He.,...&Ye, Xin-Shan.(2009).Discovery of Iminosugar Derivatives with Strong IFN-gamma Inducing Activity.CHEMMEDCHEM,4(5),756-760.
MLA Zhang, Lei,et al."Discovery of Iminosugar Derivatives with Strong IFN-gamma Inducing Activity".CHEMMEDCHEM 4.5(2009):756-760.
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