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学科主题: 药学
题名:
Discovery of Iminosugar Derivatives with Strong IFN-gamma Inducing Activity
作者: Zhang, Lei1,2; Sun, Fang1,2; Wang, Qilong3; Zhou, Jing3; Zhang, Li-He1,2; Zhang, Xiao-Lian3; Ye, Xin-Shan1,2
关键词: antibacterial agents ; iminosugars ; interferon-gamma ; library screening ; synthesis
刊名: CHEMMEDCHEM
发表日期: 2009-05-01
DOI: 10.1002/cmdc.200900027
卷: 4, 期:5, 页:756-760
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: INTERFERON-GAMMA ; MYCOBACTERIAL INFECTION ; GLYCOSIDASE INHIBITORS ; TARGETED DISRUPTION ; RECEPTOR ; MICE ; AGENTS ; SUSCEPTIBILITY ; DEFECTS ; GROWTH
英文摘要:

Through effective construction of a compound library and in situ cell-based screening, several iminosugar derivatives were discovered that show a strong ability to enhance IFN-gamma secretion. In particular, compounds A45 and B8, which exhibit remarkable activity in stimulating IFN-gamma secretion, show good antibacterial activity in vivo and have the potential to be lead compounds for further studies in the search for drugs for the treatment of cancer′ and microbial infections.

语种: 英语
项目资助者: Ministry of Science and Technology of China
WOS记录号: WOS:000266385000008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61572
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Wuhan Univ, Coll Med, Dept Immunol, State Key Lab Virol Hubei Prov Key Lab Allergy &, Wuhan 430071, Peoples R China

Recommended Citation:
Zhang, Lei,Sun, Fang,Wang, Qilong,et al. Discovery of Iminosugar Derivatives with Strong IFN-gamma Inducing Activity[J]. CHEMMEDCHEM,2009,4(5):756-760.
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