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Biomimetic synthesis and biocompatibility evaluation of carbonated apatites template-mediated by heparin
Deng, Yi1,2; Sun, Yuhua1; Chen, Xiaofang2; Zhu, Peizhi2,3; Wei, Shicheng1,2
关键词Biomimetic synthesis Carbonated apatite Heparin Biocompatibility Template
刊名MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
2013-07-01
DOI10.1016/j.msec.2013.03.016
33期:5页:2905-2913
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Materials Science, Biomaterials
资助者State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University&prime ; s 985 Grant ; State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University&prime ; s 985 Grant
研究领域[WOS]Materials Science
关键词[WOS]BONE MORPHOGENETIC PROTEIN-2 ; SOL-GEL SYNTHESIS ; THERMAL-DECOMPOSITION ; OSTEOGENIC ACTIVITY ; HYDROXYAPATITE ; MINERALIZATION ; BIOMINERALIZATION ; COMPOSITE ; COLLAGEN ; POLYSACCHARIDE
英文摘要

Biomimetic synthesis of carbonated apatites with good biocompatibility is a promising strategy for the broadening application of apatites for bone tissue engineering. Most researchers were interested in collagen or gelatin-based templates for synthesis of apatite minerals. Inspired by recent findings about the important role of polysaccharides in bone biomineralization, here we reported that heparin, a mucopolysaccharide, was used to synthesize carbonated apatites in vitro. The results indicated that the Ca/P ratio, carbon content, crystallinity and morphology of the apatites varied depending on the heparin concentration and the initial pH value. The morphology of apatite changed from flake-shaped to needle-shaped, and the degree of crystallinity decreased with the increasing of heparin concentration. Biocompatibility of the apatites was tested by proliferation and alkaline phosphatase activity of MC3T3-E1 cells. The results suggested that carbonated apatites synthesized in the presence of heparin were more favorable to the proliferation and differentiation of MC3T3-E1 cells compared with traditional method. In summary, the heparin concentration and the initial pH value play a key role in the chemical constitution and morphology, as well as biological properties of apatites. These biocompatible nano-apatite crystals hold great potential to be applied as bioactive materials for bone tissue engineering. (C) 2013 Elsevier B.V. All rights reserved.

语种英语
所属项目编号2007CB936103
资助者State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University&prime ; s 985 Grant ; State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University&prime ; s 985 Grant
WOS记录号WOS:000319630100057
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61575
专题北京大学口腔医学院_口腔颌面外科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Lab Interdisciplinary Studies, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
3.Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
推荐引用方式
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Deng, Yi,Sun, Yuhua,Chen, Xiaofang,et al. Biomimetic synthesis and biocompatibility evaluation of carbonated apatites template-mediated by heparin[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2013,33(5):2905-2913.
APA Deng, Yi,Sun, Yuhua,Chen, Xiaofang,Zhu, Peizhi,&Wei, Shicheng.(2013).Biomimetic synthesis and biocompatibility evaluation of carbonated apatites template-mediated by heparin.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,33(5),2905-2913.
MLA Deng, Yi,et al."Biomimetic synthesis and biocompatibility evaluation of carbonated apatites template-mediated by heparin".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 33.5(2013):2905-2913.
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