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Biomimetic synthesis and biocompatibility evaluation of carbonated apatites template-mediated by heparin
Deng, Yi1,2; Sun, Yuhua1; Chen, Xiaofang2; Zhu, Peizhi2,3; Wei, Shicheng1,2
关键词Biomimetic synthesis Carbonated apatite Heparin Biocompatibility Template
刊名MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
2013-07-01
DOI10.1016/j.msec.2013.03.016
33期:5页:2905-2913
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Materials Science, Biomaterials
研究领域[WOS]Materials Science
关键词[WOS]BONE MORPHOGENETIC PROTEIN-2 ; SOL-GEL SYNTHESIS ; THERMAL-DECOMPOSITION ; OSTEOGENIC ACTIVITY ; HYDROXYAPATITE ; MINERALIZATION ; BIOMINERALIZATION ; COMPOSITE ; COLLAGEN ; POLYSACCHARIDE
英文摘要

Biomimetic synthesis of carbonated apatites with good biocompatibility is a promising strategy for the broadening application of apatites for bone tissue engineering. Most researchers were interested in collagen or gelatin-based templates for synthesis of apatite minerals. Inspired by recent findings about the important role of polysaccharides in bone biomineralization, here we reported that heparin, a mucopolysaccharide, was used to synthesize carbonated apatites in vitro. The results indicated that the Ca/P ratio, carbon content, crystallinity and morphology of the apatites varied depending on the heparin concentration and the initial pH value. The morphology of apatite changed from flake-shaped to needle-shaped, and the degree of crystallinity decreased with the increasing of heparin concentration. Biocompatibility of the apatites was tested by proliferation and alkaline phosphatase activity of MC3T3-E1 cells. The results suggested that carbonated apatites synthesized in the presence of heparin were more favorable to the proliferation and differentiation of MC3T3-E1 cells compared with traditional method. In summary, the heparin concentration and the initial pH value play a key role in the chemical constitution and morphology, as well as biological properties of apatites. These biocompatible nano-apatite crystals hold great potential to be applied as bioactive materials for bone tissue engineering. (C) 2013 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000319630100057
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61575
专题北京大学口腔医学院_口腔颌面外科
北京大学第一临床医学院_血液内科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Lab Interdisciplinary Studies, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
3.Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
推荐引用方式
GB/T 7714
Deng, Yi,Sun, Yuhua,Chen, Xiaofang,et al. Biomimetic synthesis and biocompatibility evaluation of carbonated apatites template-mediated by heparin[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2013,33(5):2905-2913.
APA Deng, Yi,Sun, Yuhua,Chen, Xiaofang,Zhu, Peizhi,&Wei, Shicheng.(2013).Biomimetic synthesis and biocompatibility evaluation of carbonated apatites template-mediated by heparin.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,33(5),2905-2913.
MLA Deng, Yi,et al."Biomimetic synthesis and biocompatibility evaluation of carbonated apatites template-mediated by heparin".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 33.5(2013):2905-2913.
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