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学科主题: 口腔医学
题名:
Biomimetic synthesis and biocompatibility evaluation of carbonated apatites template-mediated by heparin
作者: Deng, Yi1,2; Sun, Yuhua1; Chen, Xiaofang2; Zhu, Peizhi2,3; Wei, Shicheng1,2
关键词: Biomimetic synthesis ; Carbonated apatite ; Heparin ; Biocompatibility ; Template
刊名: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
发表日期: 2013-07-01
DOI: 10.1016/j.msec.2013.03.016
卷: 33, 期:5, 页:2905-2913
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Biomaterials
研究领域[WOS]: Materials Science
关键词[WOS]: BONE MORPHOGENETIC PROTEIN-2 ; SOL-GEL SYNTHESIS ; THERMAL-DECOMPOSITION ; OSTEOGENIC ACTIVITY ; HYDROXYAPATITE ; MINERALIZATION ; BIOMINERALIZATION ; COMPOSITE ; COLLAGEN ; POLYSACCHARIDE
英文摘要:

Biomimetic synthesis of carbonated apatites with good biocompatibility is a promising strategy for the broadening application of apatites for bone tissue engineering. Most researchers were interested in collagen or gelatin-based templates for synthesis of apatite minerals. Inspired by recent findings about the important role of polysaccharides in bone biomineralization, here we reported that heparin, a mucopolysaccharide, was used to synthesize carbonated apatites in vitro. The results indicated that the Ca/P ratio, carbon content, crystallinity and morphology of the apatites varied depending on the heparin concentration and the initial pH value. The morphology of apatite changed from flake-shaped to needle-shaped, and the degree of crystallinity decreased with the increasing of heparin concentration. Biocompatibility of the apatites was tested by proliferation and alkaline phosphatase activity of MC3T3-E1 cells. The results suggested that carbonated apatites synthesized in the presence of heparin were more favorable to the proliferation and differentiation of MC3T3-E1 cells compared with traditional method. In summary, the heparin concentration and the initial pH value play a key role in the chemical constitution and morphology, as well as biological properties of apatites. These biocompatible nano-apatite crystals hold great potential to be applied as bioactive materials for bone tissue engineering. (C) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2007CB936103
项目资助者: State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University&prime ; s 985 Grant
WOS记录号: WOS:000319630100057
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61575
Appears in Collections:北京大学口腔医学院_口腔颌面外科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Lab Interdisciplinary Studies, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
3.Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

Recommended Citation:
Deng, Yi,Sun, Yuhua,Chen, Xiaofang,et al. Biomimetic synthesis and biocompatibility evaluation of carbonated apatites template-mediated by heparin[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2013,33(5):2905-2913.
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