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学科主题: 临床医学
题名:
Exacerbated Pulmonary Arterial Hypertension and Right Ventricular Hypertrophy in Animals With Loss of Function of Extracellular Superoxide Dismutase
作者: Xu, Dachun1,2,3; Guo, Haipeng1,2,4; Xu, Xin1,2; Lu, Zhongbing1,2; Fassett, John1,2; Hu, Xinli1,2; Xu, Yawei3; Tang, Qizhu4; Hu, Dayi7; Somani, Arif5; Geurts, Aron M.6; Ostertag, Eric8,9; Bache, Robert J.1,2; Weir, E. Kenneth11; Chen, Yingjie1,2
关键词: pulmonary artery hypertension ; right ventricular hypertrophy ; oxidative stress ; extracellular SOD
刊名: HYPERTENSION
发表日期: 2011-08-01
DOI: 10.1161/HYPERTENSIONAHA.110.166819
卷: 58, 期:2, 页:303-U368
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: OXIDATIVE STRESS ; RATS ; HEART ; EXPRESSION ; INDUCTION ; OVERLOAD ; PROTECTS ; CELLS ; FLOW
英文摘要:

Studies have demonstrated that increased oxidative stress contributes to the pathogenesis and the development of pulmonary artery hypertension (PAH). Extracellular superoxide dismutase (SOD3) is essential for removing extracellular superoxide anions, and it is highly expressed in lung tissue. However, it is not clear whether endogenous SOD3 can influence the development of PAH. Here we examined the effect of SOD3 knockout on hypoxia-induced PAH in mice and a loss-of-function SOD3 gene mutation (SOD3(E124D)) on monocrotaline (40 mg/kg)-induced PAH in rats. SOD3 knockout significantly exacerbated 2 weeks of hypoxia-induced right ventricular (RV) pressure and RV hypertrophy, whereas RV pressure in SOD3 knockout mice under normoxic conditions is similar to wild-type controls. In untreated control rats at age of 8 weeks, there was no significant difference between wild-type and SOD3(E124D) rats in RV pressure and the ratio of RV weight: left ventricular weight (0.25 +/- 0.02 in wild-type rats versus 0.25 +/- 0.01 in SOD3(E124D) rats). However, monocrotaline caused significantly greater increases of RV pressure in SOD3(E124D) rats (48.6 +/- 1.8 mm Hg in wild-type versus 57.5 +/- 3.1 mm Hg in SOD3(E124D) rats), of the ratio of RV weight: left ventricular weight (0.41 +/- 0.01 versus 0.50 +/- 0.09; P<0.05), and of the percentage of fully muscularized small arterioles in SOD3(E124D) rats (55.2 +/- 2.3% versus 69.9 +/- 2.6%; P<0.05). Together, these findings indicate that the endogenous SOD3 has no role in the development of PAH under control conditions but plays an important role in protecting the lung from the development of PAH under stress conditions. (Hypertension. 2011; 58: 303-309.)

语种: 英语
所属项目编号: R21HL102597 ; R21HL098719 ; R21HL098669 ; HL079168 ; GRNT2260175
项目资助者: National Heart, Lung and Blood Institute ; National Institutes of Health ; American Heart Association ; Veterans&prime ; Affairs research funding
WOS记录号: WOS:000292918000037
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61583
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Univ Minnesota, Lillehei Heart Inst, Sch Med, Minneapolis, MN 55455 USA
2.Univ Minnesota, Minneapolis, MN USA
3.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
4.Transposagen Biopharmaceut, Lexington, KY USA
5.Vet Affairs Med Ctr, Minneapolis, MN USA
6.Univ Minnesota, Div Cardiovasc, Sch Med, Minneapolis, MN 55455 USA
7.Tongji Univ, Dept Cardiol, Shanghai Peoples Hosp 10, Shanghai 200092, Peoples R China
8.Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan 430072, Peoples R China
9.Med Coll Wisconsin, Dept Physiol, Human & Mol Genet Ctr, Milwaukee, WI 53226 USA
10.Univ Kentucky, Dept Microbiol Immunol & Mol Genet, Lexington, KY USA
11.Univ Kentucky, Chandler Hosp, Dept Pathol & Lab Med, Lexington, KY USA
12.Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA

Recommended Citation:
Xu, Dachun,Guo, Haipeng,Xu, Xin,et al. Exacerbated Pulmonary Arterial Hypertension and Right Ventricular Hypertrophy in Animals With Loss of Function of Extracellular Superoxide Dismutase[J]. HYPERTENSION,2011,58(2):303-U368.
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