IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Exacerbated Pulmonary Arterial Hypertension and Right Ventricular Hypertrophy in Animals With Loss of Function of Extracellular Superoxide Dismutase
Xu, Dachun1,2,3; Guo, Haipeng1,2,4; Xu, Xin1,2; Lu, Zhongbing1,2; Fassett, John1,2; Hu, Xinli1,2; Xu, Yawei3; Tang, Qizhu4; Hu, Dayi7; Somani, Arif5; Geurts, Aron M.6; Ostertag, Eric8,9; Bache, Robert J.1,2; Weir, E. Kenneth11; Chen, Yingjie1,2
关键词pulmonary artery hypertension right ventricular hypertrophy oxidative stress extracellular SOD
刊名HYPERTENSION
2011-08-01
DOI10.1161/HYPERTENSIONAHA.110.166819
58期:2页:303-U368
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
资助者National Heart, Lung and Blood Institute ; National Institutes of Health ; American Heart Association ; Veterans&prime ; Affairs research funding ; National Heart, Lung and Blood Institute ; National Institutes of Health ; American Heart Association ; Veterans&prime ; Affairs research funding
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]OXIDATIVE STRESS ; RATS ; HEART ; EXPRESSION ; INDUCTION ; OVERLOAD ; PROTECTS ; CELLS ; FLOW
英文摘要

Studies have demonstrated that increased oxidative stress contributes to the pathogenesis and the development of pulmonary artery hypertension (PAH). Extracellular superoxide dismutase (SOD3) is essential for removing extracellular superoxide anions, and it is highly expressed in lung tissue. However, it is not clear whether endogenous SOD3 can influence the development of PAH. Here we examined the effect of SOD3 knockout on hypoxia-induced PAH in mice and a loss-of-function SOD3 gene mutation (SOD3(E124D)) on monocrotaline (40 mg/kg)-induced PAH in rats. SOD3 knockout significantly exacerbated 2 weeks of hypoxia-induced right ventricular (RV) pressure and RV hypertrophy, whereas RV pressure in SOD3 knockout mice under normoxic conditions is similar to wild-type controls. In untreated control rats at age of 8 weeks, there was no significant difference between wild-type and SOD3(E124D) rats in RV pressure and the ratio of RV weight: left ventricular weight (0.25 +/- 0.02 in wild-type rats versus 0.25 +/- 0.01 in SOD3(E124D) rats). However, monocrotaline caused significantly greater increases of RV pressure in SOD3(E124D) rats (48.6 +/- 1.8 mm Hg in wild-type versus 57.5 +/- 3.1 mm Hg in SOD3(E124D) rats), of the ratio of RV weight: left ventricular weight (0.41 +/- 0.01 versus 0.50 +/- 0.09; P<0.05), and of the percentage of fully muscularized small arterioles in SOD3(E124D) rats (55.2 +/- 2.3% versus 69.9 +/- 2.6%; P<0.05). Together, these findings indicate that the endogenous SOD3 has no role in the development of PAH under control conditions but plays an important role in protecting the lung from the development of PAH under stress conditions. (Hypertension. 2011; 58: 303-309.)

语种英语
所属项目编号R21HL102597 ; R21HL098719 ; R21HL098669 ; HL079168 ; GRNT2260175
资助者National Heart, Lung and Blood Institute ; National Institutes of Health ; American Heart Association ; Veterans&prime ; Affairs research funding ; National Heart, Lung and Blood Institute ; National Institutes of Health ; American Heart Association ; Veterans&prime ; Affairs research funding
WOS记录号WOS:000292918000037
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61583
专题北京大学第二临床医学院
作者单位1.Univ Minnesota, Lillehei Heart Inst, Sch Med, Minneapolis, MN 55455 USA
2.Univ Minnesota, Minneapolis, MN USA
3.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
4.Transposagen Biopharmaceut, Lexington, KY USA
5.Vet Affairs Med Ctr, Minneapolis, MN USA
6.Univ Minnesota, Div Cardiovasc, Sch Med, Minneapolis, MN 55455 USA
7.Tongji Univ, Dept Cardiol, Shanghai Peoples Hosp 10, Shanghai 200092, Peoples R China
8.Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan 430072, Peoples R China
9.Med Coll Wisconsin, Dept Physiol, Human & Mol Genet Ctr, Milwaukee, WI 53226 USA
10.Univ Kentucky, Dept Microbiol Immunol & Mol Genet, Lexington, KY USA
11.Univ Kentucky, Chandler Hosp, Dept Pathol & Lab Med, Lexington, KY USA
12.Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA
推荐引用方式
GB/T 7714
Xu, Dachun,Guo, Haipeng,Xu, Xin,et al. Exacerbated Pulmonary Arterial Hypertension and Right Ventricular Hypertrophy in Animals With Loss of Function of Extracellular Superoxide Dismutase[J]. HYPERTENSION,2011,58(2):303-U368.
APA Xu, Dachun.,Guo, Haipeng.,Xu, Xin.,Lu, Zhongbing.,Fassett, John.,...&Chen, Yingjie.(2011).Exacerbated Pulmonary Arterial Hypertension and Right Ventricular Hypertrophy in Animals With Loss of Function of Extracellular Superoxide Dismutase.HYPERTENSION,58(2),303-U368.
MLA Xu, Dachun,et al."Exacerbated Pulmonary Arterial Hypertension and Right Ventricular Hypertrophy in Animals With Loss of Function of Extracellular Superoxide Dismutase".HYPERTENSION 58.2(2011):303-U368.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xu, Dachun]的文章
[Guo, Haipeng]的文章
[Xu, Xin]的文章
百度学术
百度学术中相似的文章
[Xu, Dachun]的文章
[Guo, Haipeng]的文章
[Xu, Xin]的文章
必应学术
必应学术中相似的文章
[Xu, Dachun]的文章
[Guo, Haipeng]的文章
[Xu, Xin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。