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学科主题: 临床医学
题名:
Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis
作者: Wang, Jing; Zhang, Yun; Tang, Lu; Zhang, Nan; Fan, Dongsheng
关键词: Amyotrophic lateral sclerosis ; Resveratrol ; Nicotinamide ; Sirtuin ; Mitochondria biogenesis
刊名: NEUROSCIENCE LETTERS
发表日期: 2011-10-10
DOI: 10.1016/j.neulet.2011.08.047
卷: 503, 期:3, 页:250-255
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: LIFE-SPAN ; GENE ; G93A ; ALS ; PGC-1-ALPHA ; DEACETYLASE ; METABOLISM ; MOUSE
英文摘要:

Resveratrol has recently been widely reported to be an age-delaying and neuroprotective compound, and it appears to produce these benefits by activating silent mating type information regulation 2 homolog 1 (SIRT1). However, the role that SIRT1 activation plays in the pathogenesis of amyotrophic lateral sclerosis (ALS) remains unclear. In the present study. SIRT1 expression was found to be much lower in the mutant hSOD1G93A-bearing VSC4.1 cells compared to hSOD1wt cells when both were cultured in low-serum medium, indicating the involvement of SIRT1 activation defects in the pathogenesis of ALS under energetic stress. Further investigation revealed that a 24-h treatment with 0.5-20 mu M resveratrol had a dose-dependent protective effect on this ALS cell model, and the effects of resveratrol on increasing cell viability, preventing cell apoptosis and elevating cellular ATP levels through promoting mitochondria biogenesis were blocked by SIRT1 inhibition. This further demonstrated a role for SIRT1 activation in the protection of neuronal cells from degeneration. These findings suggest that resveratrol can protect the ALS cell model from mutant SOD1-mediated toxicity through up-regulating the expression of SIRT1, which represents a potential therapeutic target for preventing the motor neuron degeneration in ALS patients. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 81030019 ; 30871359 ; 7082099 ; 7102161 ; SF-2009-III-34
项目资助者: National Natural Sciences Foundation of China ; Beijing Natural Science Foundation ; Capital Medical Technology Development Foundation
WOS记录号: WOS:000296416000020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61584
Appears in Collections:北京大学第三临床医学院_神经内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Neurol, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Jing,Zhang, Yun,Tang, Lu,et al. Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis[J]. NEUROSCIENCE LETTERS,2011,503(3):250-255.
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