IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Serum lipid concentrations and prevalence of dyslipidemia in a large professional population in Beijing
Li, ZY; Yang, RF; Xu, GB; Xia, T
刊名CLINICAL CHEMISTRY
2005
DOI10.1373/clinchem.2004.038646
51期:1页:144-150
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]CORONARY-HEART-DISEASE ; HIGH-DENSITY-LIPOPROTEIN ; PRIMARY-PREVENTION TRIAL ; HIGH BLOOD CHOLESTEROL ; HDL-CHOLESTEROL ; EXPERT PANEL ; RISK-FACTORS ; MEN ; FRAMINGHAM ; ADULTS
英文摘要

Background: Lipid abnormalities are major risk factors for premature coronary artery diseases. We investigated serum lipids and the prevalence of dyslipidemia in a professional population in Beijing and compared these data with those obtained in a similar population during 1984-1986.

Methods: We studied 14 963 individuals 20-90 years of age. Health status was determined by questionnaires and physical check-ups. Total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), and total triglycerides (TGs) were measured. TC >5.7 mmol/L, LDL-C >3.6 mmol/L, TGs >1.7 mmol/L, and HDL-C <0.9 mmol/L were defined as abnormal.

Results: Mean serum TC, LDL-C, and TG concentrations were increased compared with the values obtained in 1984-1986, with 52.7% of males and 42.9% of females having at least one abnormal lipid concentration. Hypercholesterolemia occurred in 6% of males and 2.8% of females in the younger group (20-39 years) and in 20.2% of males and 38.7% of females in the older group (>60 years). HDL-C was abnormally low in similar to7% of males and in 1.6% of females. The prevalences of hypercholesterolemia, hypertriglyceridemia, and abnormally low HDL-C, especially the presence of slight hypertriglyceridemia, were higher than in 1984-1986 in all age groups. The increase was most prominent in the middle age group (40-59 years).

Conclusions: Hypercholesterolemia, hypertriglyceridemia, and abnormally low HDL-C have increased considerably over the past 20 years in professional populations in Beijing. Dietary changes and less physical activity resulting from rapid improvements in living conditions may be the causes for the increases. Enhanced prevenlive measures should be undertaken to modify these situations. (C) 2005 American Association for Clinical Chemistry.

语种英语
WOS记录号WOS:000225991100025
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61587
专题北京大学第一临床医学院
作者单位Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Li, ZY,Yang, RF,Xu, GB,et al. Serum lipid concentrations and prevalence of dyslipidemia in a large professional population in Beijing[J]. CLINICAL CHEMISTRY,2005,51(1):144-150.
APA Li, ZY,Yang, RF,Xu, GB,&Xia, T.(2005).Serum lipid concentrations and prevalence of dyslipidemia in a large professional population in Beijing.CLINICAL CHEMISTRY,51(1),144-150.
MLA Li, ZY,et al."Serum lipid concentrations and prevalence of dyslipidemia in a large professional population in Beijing".CLINICAL CHEMISTRY 51.1(2005):144-150.
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