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学科主题: 临床医学
题名:
Association between CISH polymorphisms and spontaneous clearance of hepatitis B virus in hepatitis B extracellular antigen-positive patients during immune active phase
作者: Song Guangjun; Rao Huiying; Feng Bo; Wei Lai
关键词: CISH ; gene polymorphism ; HBeAg positive ; chronic hepatitis B ; HBeAg seroconversion
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-05-05
DOI: 10.3760/cma.j.issn.0366-6999.20132627
卷: 127, 期:9, 页:1691-1695
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: GENOME-WIDE ASSOCIATION ; NATURAL-HISTORY ; DENDRITIC CELLS ; LIVER TOLERANCE ; T-CELLS ; INFECTION ; ACTIVATION ; PROTEIN ; EXPRESSION ; DISEASES
英文摘要:

Background Some hepatitis B extracellular antigen (HBeAg)-positive chronic hepatitis B (CHB) patients in their immune active phase can clear the virus spontaneously and enter into an inactive hepatitis B virus (HBV) carrier state, indicating a benign prognosis. In this study, the association between cytokine-inducible SRC homology 2 domain protein (CISH) gene polymorphisms at -292 (rs414171) and the spontaneous clearance of HBV in HBeAg-positive CHB patients in immune the active phase was investigated.

Methods Seventy HBeAg-positive CHB patients in the immune active phase were followed up for 76 weeks without antiviral therapy. The alanine transaminase, aspartate transaminase, HBV DNA, HBeAg and hepatitis B extracellular antibody levels were tested regularly. At week 76, 27 patients were classified into group A (HBV DNA level below 2 10(4) IU/ml and the value of HBeAg declined below 10% of the baseline at week 76), and 43 patients were classified into group B (HBV DNA level higher than 2x10(4) IU/ml or the value of HBeAg did not decline substantially at week 76). CISH (rs414171) polymorphisms were also tested using the iPLEX system.

Results The HBV DNA levels at week 12 were significantly greater in group B compared with group A (group A: (6.87 +/- 1.40) log(10)IU/ml; group B: (7.61 +/- 1.38) log(10)IU/ml, P=0.034) and the HBeAg values were greater in group B at week 28 compared with group A (P=0.001). The differences in HBV DNA and HBeAg values increased between the groups over time. Sixteen patients in group A and 11 in group B were genotype AA. Those with genotype AT or TT included 11 in group A and 31 in group B (AA vs. AT and TT, odds ratio 4.10 (95% confidence interval: 1.462-11.491), P=0.006).

Conclusion CISH gene polymorphisms at -292 (rs414171) are associated with HBV clearance in HBeAg-positive CHB patients in the immune active phase, and AA is a favorable genotype for this effect.

语种: 英语
WOS记录号: WOS:000335936800016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61588
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: Peking Univ, Peking Univ Peoples Hosp, Peking Univ Hepatol Inst, Beijing Key Lab Hepatitis & Immunotherapy Liver D, Beijing 100044, Peoples R China

Recommended Citation:
Song Guangjun,Rao Huiying,Feng Bo,et al. Association between CISH polymorphisms and spontaneous clearance of hepatitis B virus in hepatitis B extracellular antigen-positive patients during immune active phase[J]. CHINESE MEDICAL JOURNAL,2014,127(9):1691-1695.
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