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学科主题临床医学
Association between CISH polymorphisms and spontaneous clearance of hepatitis B virus in hepatitis B extracellular antigen-positive patients during immune active phase
Song Guangjun; Rao Huiying; Feng Bo; Wei Lai
关键词CISH gene polymorphism HBeAg positive chronic hepatitis B HBeAg seroconversion
刊名CHINESE MEDICAL JOURNAL
2014-05-05
DOI10.3760/cma.j.issn.0366-6999.20132627
127期:9页:1691-1695
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]GENOME-WIDE ASSOCIATION ; NATURAL-HISTORY ; DENDRITIC CELLS ; LIVER TOLERANCE ; T-CELLS ; INFECTION ; ACTIVATION ; PROTEIN ; EXPRESSION ; DISEASES
英文摘要

Background Some hepatitis B extracellular antigen (HBeAg)-positive chronic hepatitis B (CHB) patients in their immune active phase can clear the virus spontaneously and enter into an inactive hepatitis B virus (HBV) carrier state, indicating a benign prognosis. In this study, the association between cytokine-inducible SRC homology 2 domain protein (CISH) gene polymorphisms at -292 (rs414171) and the spontaneous clearance of HBV in HBeAg-positive CHB patients in immune the active phase was investigated.

Methods Seventy HBeAg-positive CHB patients in the immune active phase were followed up for 76 weeks without antiviral therapy. The alanine transaminase, aspartate transaminase, HBV DNA, HBeAg and hepatitis B extracellular antibody levels were tested regularly. At week 76, 27 patients were classified into group A (HBV DNA level below 2 10(4) IU/ml and the value of HBeAg declined below 10% of the baseline at week 76), and 43 patients were classified into group B (HBV DNA level higher than 2x10(4) IU/ml or the value of HBeAg did not decline substantially at week 76). CISH (rs414171) polymorphisms were also tested using the iPLEX system.

Results The HBV DNA levels at week 12 were significantly greater in group B compared with group A (group A: (6.87 +/- 1.40) log(10)IU/ml; group B: (7.61 +/- 1.38) log(10)IU/ml, P=0.034) and the HBeAg values were greater in group B at week 28 compared with group A (P=0.001). The differences in HBV DNA and HBeAg values increased between the groups over time. Sixteen patients in group A and 11 in group B were genotype AA. Those with genotype AT or TT included 11 in group A and 31 in group B (AA vs. AT and TT, odds ratio 4.10 (95% confidence interval: 1.462-11.491), P=0.006).

Conclusion CISH gene polymorphisms at -292 (rs414171) are associated with HBV clearance in HBeAg-positive CHB patients in the immune active phase, and AA is a favorable genotype for this effect.

语种英语
WOS记录号WOS:000335936800016
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61588
专题北京大学第二临床医学院_肝病科
北京大学第二临床医学院_北京大学肝病研究所
作者单位Peking Univ, Peking Univ Peoples Hosp, Peking Univ Hepatol Inst, Beijing Key Lab Hepatitis & Immunotherapy Liver D, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Song Guangjun,Rao Huiying,Feng Bo,et al. Association between CISH polymorphisms and spontaneous clearance of hepatitis B virus in hepatitis B extracellular antigen-positive patients during immune active phase[J]. CHINESE MEDICAL JOURNAL,2014,127(9):1691-1695.
APA Song Guangjun,Rao Huiying,Feng Bo,&Wei Lai.(2014).Association between CISH polymorphisms and spontaneous clearance of hepatitis B virus in hepatitis B extracellular antigen-positive patients during immune active phase.CHINESE MEDICAL JOURNAL,127(9),1691-1695.
MLA Song Guangjun,et al."Association between CISH polymorphisms and spontaneous clearance of hepatitis B virus in hepatitis B extracellular antigen-positive patients during immune active phase".CHINESE MEDICAL JOURNAL 127.9(2014):1691-1695.
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