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学科主题: 临床医学
题名:
Early Spatiotemporal Progress of Myelinated Nerve Fiber Regenerating through Biological Chitin Conduit after Injury
作者: Zhang, Cheng; Zhang, Peixun; Wang, Yanhua; Yu, Kai; Kou, Yuhui; Jiang, Baoguo
关键词: Peripheral nerve regeneration ; conduit ; Schwann cell ; axon ; rats
刊名: ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
发表日期: 2010-04-01
DOI: 10.3109/10731191003634836
卷: 38, 期:2, 页:103-108
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Biotechnology & Applied Microbiology ; Engineering ; Materials Science
关键词[WOS]: PERIPHERAL-NERVE ; SCIATIC-NERVE ; SCHWANN-CELLS ; SMALL-GAP ; AXONS ; DEGENERATION ; RATS ; MECHANISMS ; COLLAGEN ; DEFECT
英文摘要:

Chitin conduits to bridge nerve injuries with a small gap (2mm) give us a biological window in which the peripheral nerve regeneration process can be observed. In this study, the regeneration process was observed on different intervals postoperatively. Histological analysis revealed that the early regeneration process occurred in three phase: degeneration and matrix phase, axonal and Schwann migration phase, myelination and maturation phase. Schwann cells grew into the lumen from both the proximal and distal nerve segments. Axonal regrowth progressed at an average rate of 1.4 mm/d. Regenerating axonal fibers were myelinated by Schwann cells from both sides of the conduit.

语种: 英语
所属项目编号: 30625036 ; 2005CB522604 ; 30801169 ; A-2008-10 ; 20070001780
项目资助者: Chinese National Science Fund for Outstanding Youth ; Chinese 973 Project Planning ; Chinese National Natural Science Youth Fund ; Beijing City Science and Technology New Star Classification ; Chinese ministry of education for Doctor Position New Teacher
WOS记录号: WOS:000275467100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61590
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100044, Peoples R China

Recommended Citation:
Zhang, Cheng,Zhang, Peixun,Wang, Yanhua,et al. Early Spatiotemporal Progress of Myelinated Nerve Fiber Regenerating through Biological Chitin Conduit after Injury[J]. ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY,2010,38(2):103-108.
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