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学科主题: 临床医学
题名:
Locally Advanced Rectal Carcinoma Treated with Preoperative Chemotherapy and Radiation Therapy: Preliminary Analysis of Diffusion-weighted MR Imaging for Early Detection of Tumor Histopathologic Downstaging
作者: Sun, Ying-Shi1; Zhang, Xiao-Peng1; Tang, Lei1; Ji, Jia-Fu2; Gu, Jin; Cai, Yong3; Zhang, Xiao-Yan1
刊名: RADIOLOGY
发表日期: 2010
DOI: 10.1148/radiol.2541082230
卷: 254, 期:1, 页:170-178
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: EARLY SURROGATE MARKER ; IN-VIVO ; PREDICTING RESPONSE ; THYMIDINE KINASE ; BREAST-CANCER ; CELL-DENSITY ; BRAIN-TUMORS ; CHEMORADIATION ; RADIOTHERAPY ; SURVIVAL
英文摘要:

Purpose: To determine whether changes in apparent diffusion coefficients (ADCs) of rectal carcinoma obtained 1 week after the beginning of chemotherapy and radiation therapy (CRT) correlate with tumor histopathologic downstaging after preoperative CRT.

Materials and Methods: This prospective study was approved by an institutional review board; informed consent was obtained from all patients. Thirty-seven patients (mean age, 54.7 years; 13 women, 24 men) with primary rectal carcinoma who were undergoing preoperative CRT were recruited for the study. Diffusion-weighted (DW) magnetic resonance (MR) imaging was performed with a 1.5-T MR imager in all patients before therapy, at the end of the 1st and 2nd week of therapy, and before surgery. Tumor ADCs were calculated. Linear mixed-effects modeling was applied to analyze change in ADCs and volumes following treatment.

Results: Patients were assigned to the tumor downstaged group (n = 17) or the tumor nondownstaged group (n = 20) on the basis of histopathologic examination results following surgery. Before CRT, the mean tumor ADC in the downstaged group was lower than that in the nondownstaged group (1.07 x 10(-3) mm(2)/sec +/- 0.13 [standard deviation] vs 1.19 x 10(-3) mm(2)/sec +/- 0.15, F = 6.91, P=.013). At the end of the 1st week of CRT, the mean tumor ADC increased significantly from 1.07 x 10(-3)mm(2)/sec +/- 0.13 to 1.32 x 10(-3) mm(2)/sec +/- 0.16 (F = 37.63, P<.001) in the downstaged group, but there was no significant ADC increase in the nondownstaged group (F = 1.18, P=.291). The mean percentage of tumor ADC change in the downstaged group was significantly higher than that in the nondownstaged group at each time point (F = 18.39, P<.001).

Conclusion: Early increase of mean tumor ADC and low pretherapy mean ADC in rectal carcinoma correlate with good response to CRT. DW MR imaging is a promising noninvasive technique for helping predict and monitor early therapeutic response in patients with rectal carcinoma who are undergoing CRT. (C) RSNA, 2009

语种: 英语
所属项目编号: 2006CB705706 ; 7072018
项目资助者: National Basic Research Program of China ; Natural Science Foundation of Beijing, China
WOS记录号: WOS:000273820400022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61591
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Beijing Canc Hosp & Inst, Minist Educ,Dept Radiol,Sch Oncol, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Surg, Beijing 100142, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Radiotherapy, Beijing 100142, Peoples R China

Recommended Citation:
Sun, Ying-Shi,Zhang, Xiao-Peng,Tang, Lei,et al. Locally Advanced Rectal Carcinoma Treated with Preoperative Chemotherapy and Radiation Therapy: Preliminary Analysis of Diffusion-weighted MR Imaging for Early Detection of Tumor Histopathologic Downstaging[J]. RADIOLOGY,2010,254(1):170-178.
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