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学科主题临床医学
Locally Advanced Rectal Carcinoma Treated with Preoperative Chemotherapy and Radiation Therapy: Preliminary Analysis of Diffusion-weighted MR Imaging for Early Detection of Tumor Histopathologic Downstaging
Sun, Ying-Shi1; Zhang, Xiao-Peng1; Tang, Lei1; Ji, Jia-Fu2; Gu, Jin; Cai, Yong3; Zhang, Xiao-Yan1
刊名RADIOLOGY
2010
DOI10.1148/radiol.2541082230
254期:1页:170-178
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]EARLY SURROGATE MARKER ; IN-VIVO ; PREDICTING RESPONSE ; THYMIDINE KINASE ; BREAST-CANCER ; CELL-DENSITY ; BRAIN-TUMORS ; CHEMORADIATION ; RADIOTHERAPY ; SURVIVAL
英文摘要

Purpose: To determine whether changes in apparent diffusion coefficients (ADCs) of rectal carcinoma obtained 1 week after the beginning of chemotherapy and radiation therapy (CRT) correlate with tumor histopathologic downstaging after preoperative CRT.

Materials and Methods: This prospective study was approved by an institutional review board; informed consent was obtained from all patients. Thirty-seven patients (mean age, 54.7 years; 13 women, 24 men) with primary rectal carcinoma who were undergoing preoperative CRT were recruited for the study. Diffusion-weighted (DW) magnetic resonance (MR) imaging was performed with a 1.5-T MR imager in all patients before therapy, at the end of the 1st and 2nd week of therapy, and before surgery. Tumor ADCs were calculated. Linear mixed-effects modeling was applied to analyze change in ADCs and volumes following treatment.

Results: Patients were assigned to the tumor downstaged group (n = 17) or the tumor nondownstaged group (n = 20) on the basis of histopathologic examination results following surgery. Before CRT, the mean tumor ADC in the downstaged group was lower than that in the nondownstaged group (1.07 x 10(-3) mm(2)/sec +/- 0.13 [standard deviation] vs 1.19 x 10(-3) mm(2)/sec +/- 0.15, F = 6.91, P=.013). At the end of the 1st week of CRT, the mean tumor ADC increased significantly from 1.07 x 10(-3)mm(2)/sec +/- 0.13 to 1.32 x 10(-3) mm(2)/sec +/- 0.16 (F = 37.63, P<.001) in the downstaged group, but there was no significant ADC increase in the nondownstaged group (F = 1.18, P=.291). The mean percentage of tumor ADC change in the downstaged group was significantly higher than that in the nondownstaged group at each time point (F = 18.39, P<.001).

Conclusion: Early increase of mean tumor ADC and low pretherapy mean ADC in rectal carcinoma correlate with good response to CRT. DW MR imaging is a promising noninvasive technique for helping predict and monitor early therapeutic response in patients with rectal carcinoma who are undergoing CRT. (C) RSNA, 2009

语种英语
WOS记录号WOS:000273820400022
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被引频次:159[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61591
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
北京大学临床肿瘤学院_肿瘤放疗科
北京大学临床肿瘤学院_医学影像科
作者单位1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Beijing Canc Hosp & Inst, Minist Educ,Dept Radiol,Sch Oncol, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Surg, Beijing 100142, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Radiotherapy, Beijing 100142, Peoples R China
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Sun, Ying-Shi,Zhang, Xiao-Peng,Tang, Lei,et al. Locally Advanced Rectal Carcinoma Treated with Preoperative Chemotherapy and Radiation Therapy: Preliminary Analysis of Diffusion-weighted MR Imaging for Early Detection of Tumor Histopathologic Downstaging[J]. RADIOLOGY,2010,254(1):170-178.
APA Sun, Ying-Shi.,Zhang, Xiao-Peng.,Tang, Lei.,Ji, Jia-Fu.,Gu, Jin.,...&Zhang, Xiao-Yan.(2010).Locally Advanced Rectal Carcinoma Treated with Preoperative Chemotherapy and Radiation Therapy: Preliminary Analysis of Diffusion-weighted MR Imaging for Early Detection of Tumor Histopathologic Downstaging.RADIOLOGY,254(1),170-178.
MLA Sun, Ying-Shi,et al."Locally Advanced Rectal Carcinoma Treated with Preoperative Chemotherapy and Radiation Therapy: Preliminary Analysis of Diffusion-weighted MR Imaging for Early Detection of Tumor Histopathologic Downstaging".RADIOLOGY 254.1(2010):170-178.
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