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Expression and regulation of adipocyte fatty acid binding protein in granulosa cells and its relation with clinical characteristics of polycystic ovary syndrome
Hu, Weihong1,2; Qiao, Jie1
关键词Polycystic ovary syndrome Adipocyte fatty acid binding protein Granulosa cell
刊名ENDOCRINE
2011-10-01
DOI10.1007/s12020-011-9495-9
40期:2页:196-202
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]ACTIVATED-RECEPTOR-GAMMA ; INSULIN-RESISTANCE ; METABOLIC SYNDROME ; CARDIOVASCULAR-DISEASE ; OBESITY ; WOMEN ; AP2 ; ATHEROSCLEROSIS ; MICE ; HYPERANDROGENISM
英文摘要

Increased expression of adipocyte fatty acid binding protein (FABP4) is associated with type 2 diabetic, high triglycerides, increased lipid peroxidation, and inflammation markers. To study the expression of FABP4 mRNA in granulosa cells of patients with polycystic ovary syndrome (PCOS) and the impact of testosterone, insulin, and PPAR gamma agonist rosiglitazone on granulosa cells (GCs), and to investigate the relationship of serum FABP4 levels with clinical characteristics in patients with PCOS. The expression of FABP4 mRNA in GCs of patients with PCOS and normal controls were assayed by RT-PCR. We assessed the level of FABP4 mRNA after treatment with testosterone, insulin, and rosiglitazone in GCs from normal controls. Serum FABP4 were assayed from 96 patients with PCOS (obese and nonobese 48 cases, respectively) and 80 healthy normal controls (obese and the nonobese 40 cases, respectively). The expression of FABP4 mRNA was higher in the GCs of PCOS than that of the controls (P < 0.05). FABP4 mRNA expression was up-regulated by testosterone, insulin, and rosiglitazone at different dosages. Serum FABP4 levels were higher in the nonobese PCOS group than that of the nonobese controls (8.9 +/- 5.1 ng/ml vs. 4.8 +/- 0.7 ng/ml), and in the obese PCOS group than that of the obese controls (28.2 +/- 14.0 ng/ml vs. 15.6 +/- 6.6 ng/ml), respectively (P < 0.05). Multiple linear regression analyses showed that serum FABP4 level was independently associated with HOMA-IR, BMI, and testosterone (P < 0.05). Increased FABP4 was related to the clinical characteristics of PCOS.

语种英语
WOS记录号WOS:000296787800007
项目编号30825038
资助机构National Natural Science Foundation
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61597
专题北京大学第三临床医学院
北京大学第三临床医学院_生殖医学中心
作者单位1.Peking Univ, Dept Gynecol & Obstet, Hosp 3, Beijing 100083, Peoples R China
2.Gen Hosp Chinese Peoples Armed Police Forces, Dept Gynecol & Obstet, Beijing 100039, Peoples R China
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GB/T 7714
Hu, Weihong,Qiao, Jie. Expression and regulation of adipocyte fatty acid binding protein in granulosa cells and its relation with clinical characteristics of polycystic ovary syndrome[J]. ENDOCRINE,2011,40(2):196-202.
APA Hu, Weihong,&Qiao, Jie.(2011).Expression and regulation of adipocyte fatty acid binding protein in granulosa cells and its relation with clinical characteristics of polycystic ovary syndrome.ENDOCRINE,40(2),196-202.
MLA Hu, Weihong,et al."Expression and regulation of adipocyte fatty acid binding protein in granulosa cells and its relation with clinical characteristics of polycystic ovary syndrome".ENDOCRINE 40.2(2011):196-202.
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