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学科主题: 临床医学
题名:
Rs548234 polymorphism at PRDM1-ATG5 region susceptible to rheumatoid arthritis in Caucasians is not associated with rheumatoid arthritis in Chinese Han population
作者: Lu Xiao-lan1; Zhou Xu-jie2; Guo Jian-ping1; Jia Ru-lin1; Zhao Yi3; Jiang Quan4; Liu Xiang-yuan5; Liu Yi6; Sun Ling-yun7; Zhang Hong2; Li Zhan-guo1
关键词: rheumatoid arthritis ; PRDM1/ATG5 ; genetic association ; Chinese Han population
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2011-09-20
DOI: 10.3760/cma.j.issn.0366-6999.2011.18.012
卷: 124, 期:18, 页:2863-2867
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: RISK LOCUS ; PTPN22 ; GENE ; DISEASE ; AUTOPHAGY ; BLIMP-1 ; PADI4 ; REPLICATION ; MECHANISMS ; IMMUNITY
英文摘要:

Background A previous study has shown that rs548234 polymorphism at PRDM1-ATG5 region is associated with rheumatoid arthritis (RA) in Caucasian populations. The aim of this study was to investigate the effect of rs548234 polymorphism at PRDM1-ATG5 region on susceptibility to RA in Chinese Han population.

Methods We genotyped 848 RA patients and 1431 matched healthy controls for rs548234 single-nucleotide polymorphism (SNP) with a predesigned TaqMan SNP genotyping assay. Association analyses were performed on the whole data set and on rheumatoid factors (RF) and anti-cyclic citrullinated peptides (anti-CCP) antibody. Finally, we carried out combined analysis of rs548234 association with RA based on the published data.

Results No significant difference in the genotype distribution between RA patients and healthy controls for rs548234 (UT) polymorphism was found in Chinese Han population, neither in whole data set nor in stratified subsets, e.g. RF and anti-CCP status. Association analysis in different ethnic groups showed that rs548234 at PRDM1-ATG5 region was associated with RA in Caucasian ancestry but not in East Asian population.

Conclusions Our results showed no involvement of rs548234 at PRDM1-ATG5 region in the susceptibility or clinical relevance of RA in Chinese Han population. Chin Med J 2011;124(18):2863-2867

语种: 英语
所属项目编号: 2010CB529100 ; 81030057
项目资助者: Major State Basic Research Development Program of China (973 Program) ; National Natural Science Foundation of China
WOS记录号: WOS:000295297500013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61603
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Inst Nephrol, Hosp 1, Renal Div,Key Lab Renal Dis,Minist Hlth China, Beijing 100034, Peoples R China
3.Capital Med Univ, Xuanwu Hosp, Dept Rheumatol, Beijing 100053, Peoples R China
4.China Acad Chinese Med Sci, Guanganmen Hosp, Dept Rheumatol, Beijing 100053, Peoples R China
5.Peking Univ, Dept Rheumatol & Immunol, Hosp 3, Beijing 100191, Peoples R China
6.Sichuan Univ, W China Hosp, Dept Rheumatol, Chengdu 610041, Sichuan, Peoples R China
7.Nanjing Univ, Drum Tower Hosp, Dept Rheumatol, Sch Med, Nanjing 210008, Jiangsu, Peoples R China

Recommended Citation:
Lu Xiao-lan,Zhou Xu-jie,Guo Jian-ping,et al. Rs548234 polymorphism at PRDM1-ATG5 region susceptible to rheumatoid arthritis in Caucasians is not associated with rheumatoid arthritis in Chinese Han population[J]. CHINESE MEDICAL JOURNAL,2011,124(18):2863-2867.
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