IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Targeting HDACs: A Promising Therapy for Alzheimer′s Disease
Xu, Ke2; Dai, Xue-Ling1,3; Huang, Han-Chang1; Jiang, Zhao-Feng1,4
刊名OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
2011
DOI10.1155/2011/143269
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]HISTONE DEACETYLASE INHIBITORS ; MOUSE MODEL ; TAU PHOSPHORYLATION ; MEMORY IMPAIRMENT ; REGULATES MEMORY ; ACETYLATION ; HYPOTHESIS ; PLASTICITY ; REDUCTION ; TOXICITY
英文摘要

Epigenetic modifications like DNA methylation and histone acetylation play an important role in a wide range of brain disorders. Histone deacetylases (HDACs) regulate the homeostasis of histone acetylation. Histone deacetylase inhibitors, which initially were used as anticancer drugs, are recently suggested to act as neuroprotectors by enhancing synaptic plasticity and learning and memory in a wide range of neurodegenerative and psychiatric disorders, such as Alzheimer′s disease (AD) and Parkinson′s disease (PD). To reveal the physiological roles of HDACs may provide us with a new perspective to understand the mechanism of AD and to develop selective HDAC inhibitors. This paper focuses on the recent research progresses of HDAC proteins and their inhibitors on the roles of the treatment for AD.

语种英语
WOS记录号WOS:000296867200001
项目编号31071512 ; PHR20090514
资助机构National Natural Science Foundation of China ; Jurisdiction of Beijing Municipality (PHR(IHLB))
引用统计
被引频次:54[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61621
专题北京大学基础医学院
作者单位1.Beijing Union Univ, Coll Arts & Sci, Beijing 100191, Peoples R China
2.Capital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
3.Peking Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
4.Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xu, Ke,Dai, Xue-Ling,Huang, Han-Chang,et al. Targeting HDACs: A Promising Therapy for Alzheimer′s Disease[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2011.
APA Xu, Ke,Dai, Xue-Ling,Huang, Han-Chang,&Jiang, Zhao-Feng.(2011).Targeting HDACs: A Promising Therapy for Alzheimer′s Disease.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY.
MLA Xu, Ke,et al."Targeting HDACs: A Promising Therapy for Alzheimer′s Disease".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2011).
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