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学科主题: 基础医学
题名:
Targeting HDACs: A Promising Therapy for Alzheimer′s Disease
作者: Xu, Ke2; Dai, Xue-Ling1,3; Huang, Han-Chang1; Jiang, Zhao-Feng1,4
刊名: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
发表日期: 2011
DOI: 10.1155/2011/143269
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: HISTONE DEACETYLASE INHIBITORS ; MOUSE MODEL ; TAU PHOSPHORYLATION ; MEMORY IMPAIRMENT ; REGULATES MEMORY ; ACETYLATION ; HYPOTHESIS ; PLASTICITY ; REDUCTION ; TOXICITY
英文摘要:

Epigenetic modifications like DNA methylation and histone acetylation play an important role in a wide range of brain disorders. Histone deacetylases (HDACs) regulate the homeostasis of histone acetylation. Histone deacetylase inhibitors, which initially were used as anticancer drugs, are recently suggested to act as neuroprotectors by enhancing synaptic plasticity and learning and memory in a wide range of neurodegenerative and psychiatric disorders, such as Alzheimer′s disease (AD) and Parkinson′s disease (PD). To reveal the physiological roles of HDACs may provide us with a new perspective to understand the mechanism of AD and to develop selective HDAC inhibitors. This paper focuses on the recent research progresses of HDAC proteins and their inhibitors on the roles of the treatment for AD.

语种: 英语
所属项目编号: 31071512 ; PHR20090514
项目资助者: National Natural Science Foundation of China ; Jurisdiction of Beijing Municipality (PHR(IHLB))
WOS记录号: WOS:000296867200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61621
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Beijing Union Univ, Coll Arts & Sci, Beijing 100191, Peoples R China
2.Capital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
3.Peking Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
4.Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

Recommended Citation:
Xu, Ke,Dai, Xue-Ling,Huang, Han-Chang,et al. Targeting HDACs: A Promising Therapy for Alzheimer′s Disease[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2011.
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