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学科主题临床医学
Serum Protein Profile at Remission Can Accurately Assess Therapeutic Outcomes and Survival for Serous Ovarian Cancer
Wang, Jinhua1,2,3,4,5; Sharma, Ashok1; Ghamande, Sharad A.6; Bush, Stephen6; Ferris, Daron6; Zhi, Wenbo1; He, Mingfang1,2,5; Wang, Meiyao1,3; Wang, Xiaoxiao1; Miller, Eric1; Hopkins, Diane1; Macfee, Michael6; Guan, Ruili1,7; Tang, Jinhai2,3,4; She, Jin-Xiong1,2,3,5
刊名PLOS ONE
2013-11-11
DOI10.1371/journal.pone.0078393
8期:11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]BIOMARKER PANELS ; DIAGNOSIS ; PROGRESSION ; MARKERS ; CHEMOTHERAPY ; INFLAMMATION ; VALIDATION ; CA-125 ; CA125 ; ASSAY
英文摘要

Background: Biomarkers play critical roles in early detection, diagnosis and monitoring of therapeutic outcome and recurrence of cancer. Previous biomarker research on ovarian cancer (OC) has mostly focused on the discovery and validation of diagnostic biomarkers. The primary purpose of this study is to identify serum biomarkers for prognosis and therapeutic outcomes of ovarian cancer.

Experimental Design: Forty serum proteins were analyzed in 70 serum samples from healthy controls (HC) and 101 serum samples from serous OC patients at three different disease phases: post diagnosis (PD), remission (RM) and recurrence (RC). The utility of serum proteins as OC biomarkers was evaluated using a variety of statistical methods including survival analysis.

Results: Ten serum proteins (PDGF-AB/BB, PDGF-AA, CRP, sFas, CA125, SAA, sTNFRII, sIL-6R, IGFBP6 and MDC) have individually good area-under-the-curve (AUC) values (AUC = 0.69-0.86) and more than 10 three-marker combinations have excellent AUC values (0.91-0.93) in distinguishing active cancer samples (PD & RC) from HC. The mean serum protein levels for RM samples are usually intermediate between HC and OC patients with active cancer (PD & RC). Most importantly, five proteins (sICAM1, RANTES, sgp130, sTNFR-II and sVCAM1) measured at remission can classify, individually and in combination, serous OC patients into two subsets with significantly different overall survival (best HR = 17, p <10(-3)).

Conclusion: We identified five serum proteins which, when measured at remission, can accurately predict the overall survival of serous OC patients, suggesting that they may be useful for monitoring the therapeutic outcomes for ovarian cancer.

语种英语
WOS记录号WOS:000327221600026
项目编号RC2011091
资助机构Georgia Cancer Coalition ; Georgia Research Alliance as an eminent scholar ; Jiangsu Medical key Figure ; Jiangsu Government Scholarship ; "333" Plan
引用统计
被引频次:111[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61622
专题北京大学第一临床医学院
作者单位1.Georgia Hlth Sci Univ, Ctr Biotechnol & Genom Med, Augusta, GA 30912 USA
2.Nanjing Univ Technol, Sino Amer Canc Res Inst, Nanjing, Jiangsu, Peoples R China
3.Jiangsu Canc Hosp, Nanjing, Jiangsu, Peoples R China
4.Nanjing Med Univ, Jiangsu Canc Hosp, Nanjing, Jiangsu, Peoples R China
5.Nanjing Univ Technol, Sch Pharmaceut Sci, Inst Translat Med, Nanjing, Jiangsu, Peoples R China
6.Georgia Hlth Sci Univ, Dept Obstet & Gynecol, Augusta, GA USA
7.Beijing Univ, Inst Urol Surg, Hosp 1, Beijing 100871, Peoples R China
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GB/T 7714
Wang, Jinhua,Sharma, Ashok,Ghamande, Sharad A.,et al. Serum Protein Profile at Remission Can Accurately Assess Therapeutic Outcomes and Survival for Serous Ovarian Cancer[J]. PLOS ONE,2013,8(11).
APA Wang, Jinhua.,Sharma, Ashok.,Ghamande, Sharad A..,Bush, Stephen.,Ferris, Daron.,...&She, Jin-Xiong.(2013).Serum Protein Profile at Remission Can Accurately Assess Therapeutic Outcomes and Survival for Serous Ovarian Cancer.PLOS ONE,8(11).
MLA Wang, Jinhua,et al."Serum Protein Profile at Remission Can Accurately Assess Therapeutic Outcomes and Survival for Serous Ovarian Cancer".PLOS ONE 8.11(2013).
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