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学科主题: 临床医学
题名:
Serum Protein Profile at Remission Can Accurately Assess Therapeutic Outcomes and Survival for Serous Ovarian Cancer
作者: Wang, Jinhua1,2,3,4,5; Sharma, Ashok1; Ghamande, Sharad A.6; Bush, Stephen6; Ferris, Daron6; Zhi, Wenbo1; He, Mingfang1,2,5; Wang, Meiyao1,3; Wang, Xiaoxiao1; Miller, Eric1; Hopkins, Diane1; Macfee, Michael6; Guan, Ruili1,7; Tang, Jinhai2,3,4; She, Jin-Xiong1,2,3,5
刊名: PLOS ONE
发表日期: 2013-11-11
DOI: 10.1371/journal.pone.0078393
卷: 8, 期:11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: BIOMARKER PANELS ; DIAGNOSIS ; PROGRESSION ; MARKERS ; CHEMOTHERAPY ; INFLAMMATION ; VALIDATION ; CA-125 ; CA125 ; ASSAY
英文摘要:

Background: Biomarkers play critical roles in early detection, diagnosis and monitoring of therapeutic outcome and recurrence of cancer. Previous biomarker research on ovarian cancer (OC) has mostly focused on the discovery and validation of diagnostic biomarkers. The primary purpose of this study is to identify serum biomarkers for prognosis and therapeutic outcomes of ovarian cancer.

Experimental Design: Forty serum proteins were analyzed in 70 serum samples from healthy controls (HC) and 101 serum samples from serous OC patients at three different disease phases: post diagnosis (PD), remission (RM) and recurrence (RC). The utility of serum proteins as OC biomarkers was evaluated using a variety of statistical methods including survival analysis.

Results: Ten serum proteins (PDGF-AB/BB, PDGF-AA, CRP, sFas, CA125, SAA, sTNFRII, sIL-6R, IGFBP6 and MDC) have individually good area-under-the-curve (AUC) values (AUC = 0.69-0.86) and more than 10 three-marker combinations have excellent AUC values (0.91-0.93) in distinguishing active cancer samples (PD & RC) from HC. The mean serum protein levels for RM samples are usually intermediate between HC and OC patients with active cancer (PD & RC). Most importantly, five proteins (sICAM1, RANTES, sgp130, sTNFR-II and sVCAM1) measured at remission can classify, individually and in combination, serous OC patients into two subsets with significantly different overall survival (best HR = 17, p <10(-3)).

Conclusion: We identified five serum proteins which, when measured at remission, can accurately predict the overall survival of serous OC patients, suggesting that they may be useful for monitoring the therapeutic outcomes for ovarian cancer.

语种: 英语
所属项目编号: RC2011091
项目资助者: Georgia Cancer Coalition ; Georgia Research Alliance as an eminent scholar ; Jiangsu Medical key Figure ; Jiangsu Government Scholarship ; "333" Plan
WOS记录号: WOS:000327221600026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61622
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Georgia Hlth Sci Univ, Ctr Biotechnol & Genom Med, Augusta, GA 30912 USA
2.Nanjing Univ Technol, Sino Amer Canc Res Inst, Nanjing, Jiangsu, Peoples R China
3.Jiangsu Canc Hosp, Nanjing, Jiangsu, Peoples R China
4.Nanjing Med Univ, Jiangsu Canc Hosp, Nanjing, Jiangsu, Peoples R China
5.Nanjing Univ Technol, Sch Pharmaceut Sci, Inst Translat Med, Nanjing, Jiangsu, Peoples R China
6.Georgia Hlth Sci Univ, Dept Obstet & Gynecol, Augusta, GA USA
7.Beijing Univ, Inst Urol Surg, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Jinhua,Sharma, Ashok,Ghamande, Sharad A.,et al. Serum Protein Profile at Remission Can Accurately Assess Therapeutic Outcomes and Survival for Serous Ovarian Cancer[J]. PLOS ONE,2013,8(11).
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